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公开(公告)号：EP3885760A1
公开(公告)日：2021-09-29
申请号：EP19887902.5
申请日：2019-11-13
发明人： ZHAO, Yingying , CAI, Peizhi , GU, Le , PANG, Fengchun , GENG, Yue , XIAO, Yuelei , CUI, Haochen , ZHAO, Nan , LIAO, Hui , YAO, Wenliang , CHE, Chuncheng
摘要： The present disclosure provides a microfluidic chip, including: first base substrate and a second base substrate opposite to each other; first electrode and second electrode between the first base substrate and the second base substrate and configured to control droplet to move between the first base substrate and the second base substrate according to voltages applied on the first electrode and the second electrode; light guide component configured to guide light propagating in the first base substrate to the droplet; shading component and detection component, shading component having light transmission regions spaced from each other, light transmission regions being configured to transmit light passing through the droplet to the detection component, wherein detection component is on second base substrate and is configured to obtain property of the droplet according to an intensity of the light passing through droplet and received from the light transmission regions.
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2.发明公开
公开(公告)号：EP3676008A1
公开(公告)日：2020-07-08
申请号：EP18803523.2
申请日：2018-06-08
发明人： GENG, Yue , CAI, Peizhi , PANG, Fengchun , GU, Le , CHE, Chuncheng , XUE, Hailin , SHAO, Xibin
IPC分类号： B01L3/00
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公开(公告)号：EP3656843A1
公开(公告)日：2020-05-27
申请号：EP18765347.2
申请日：2018-02-11
发明人： CAI, Peizhi , PANG, Fengchun , LIU, Huazhe
摘要： The present disclosure relates to a gene sequencing structure, chip, system, and method. The gene sequencing structure comprises: a first electrode and a second electrode spaced apart from each other, a semiconductor layer, a sensing electrode, an insulating layer, and a sensitive film layer. The first electrode is connected to the second electrode via the semiconductor layer, the sensing electrode is in contact with the sensitive film layer, and the insulating layer isolates each of the sensitive film layer and the sensing electrode from each of the first electrode, the second electrode, and the semiconductor layer, wherein the sensitive film layer generates charges in response to receiving ions generated by base pairing during gene sequencing.
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公开(公告)号：EP3623462A1
公开(公告)日：2020-03-18
申请号：EP18739446.5
申请日：2018-01-02
发明人： GENG, Yue , PANG, Fengchun , CAI, Peizhi , GU, Le
摘要： Embodiments of the disclosure provide a gene sequencing chip, including: an upper substrate including a plurality of liquid inlets for inletting liquid drops; a lower substrate opposite to the upper substrate and spaced therefrom by a gap, the gap being provided for allowing the liquid drops to move therein, the lower substrate including a liquid drop operation region, the liquid drop operation region including a manipulation electrode array. The manipulation electrode array includes multiple first sub-arrays for preparing a gene library, multiple second sub-arrays for sequencing the prepared gene library, each first sub-array being adjacent to one of the second sub-arrays. Based on the gene sequencing chip provided in this disclosure, operations to tiny liquid drops such as movement, fusion and splitting can be accurately manipulated by using digital microfluidic techniques, and all steps of the gene sequencing from library preparation to gene sequencing can be completed in a programmatic manner on one chip. The chip has a high degree of integration, the liquid drops can be manipulated accurately, the consumption of the reagents can be reduced, and the preparation process is simple and mature.
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5.发明公开
公开(公告)号：EP3561510A1
公开(公告)日：2019-10-30
申请号：EP17835577.2
申请日：2017-07-12
发明人： PANG, Fengchun , CAI, Peizhi , GENG, Yue
摘要： A detection substrate and a manufacturing method thereof, and a nucleic acid detecting method are provided. The detection substrate includes at least one detection unit (100) disposed on a base substrate (10), the detection unit (100) including a first electrode (11), a second electrode (13) and a colloid layer (17), the second electrode (13) disposed on a side of the first electrode (11) away from the base substrate (10), the second electrode (13) including at least one hollowed structure (1300), the second electrode (13) and the first electrode (11) being insulated from each other, and the first electrode (11) and the second electrode (13) being configured to be applied with voltages respectively; the colloid layer (17) at least disposed on the at least one hollowed structure (1300) of the second electrode (13), the colloid layer (17) including a linker (170) configured to be paired with a target nucleic acid (18). The detection substrate performs the amplification and detection of the nucleic acid by applying voltages to the first electrode (11) and the second electrode (13) of the detection unit (100) respectively. A requirement on the structure and appearance of the first electrode (11) and the second electrode (13) are simple, which simplifies the process difficulty.
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公开(公告)号：EP3735611A1
公开(公告)日：2020-11-11
申请号：EP18898879.4
申请日：2018-09-12
发明人： PANG, Fengchun , CAI, Peizhi , GENG, Yue , GU, Le , CHE, Chuncheng , XUE, Hailin , SHAO, Xibin
IPC分类号： G02F1/1343 , G02F1/133
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公开(公告)号：EP3650861A1
公开(公告)日：2020-05-13
申请号：EP18766112.9
申请日：2018-02-07
发明人： PANG, Fengchun , CHE, Chuncheng , XUE, Hailin , SHAO, Xibin , CAI, Peizhi
IPC分类号： G01N33/558 , G01N21/64 , G01N33/569
摘要： There is provided an influenza virus detection chip and a method for detecting influenza virus therewith. An influenza virus detection chip comprising: a graphene oxide film; a bonding pad disposed on one side of the graphene oxide film in a first direction; and a first electrode and a second electrode, connected to both ends of the graphene oxide film in a second direction perpendicular to the first direction, wherein a first monoclonal antibody with a fluorescent label is included in the bonding pad, and a second monoclonal antibody is included in the graphene oxide film, and wherein the fluorescent label comprises a C=C-C=C conjugated double bond.
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公开(公告)号：EP3626811A1
公开(公告)日：2020-03-25
申请号：EP17892073.2
申请日：2017-12-15
发明人： PANG, Fengchun , CAI, Peizhi , GENG, Yue
摘要： A chip, a detection system and a gene sequencing method are provided. When the chip is used for gene sequencing, sample genes and reversible terminating nucleotides are added into micropores and matched therein to release hydrogen ions such that a Nernst potential is induced on an ion-sensitive film surface, and a voltage is applied to the transparent electrode layer to generate an electric field, thereby controlling the switching layer to change its state, and then a base type of the genes is determined based on a type of reversible terminating nucleotide corresponding to information of light emitted from the switching layer upon changes in the state of the switching layer, thereby gene sequencing is achieved. The chip has a simple structure and low fabrication cost, and the reversible terminating nucleotides for matching sequencing require no fluorescent labeling, and optical systems such as a backlight source and a laser light source are unnecessary, which greatly reduces the cost and time for gene sequencing.
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公开(公告)号：EP4059603A1
公开(公告)日：2022-09-21
申请号：EP20880340.3
申请日：2020-09-22
发明人： PANG, Fengchun
摘要： Provided are a microfluidic chip and a manufacturing method thereof, and a microfluidic device, and relates to the field of microfluidic technology. The microfluidic chip comprises a first substrate structure comprising a plurality of pin areas comprising a first and a second pin area, a detection area, and a grounding trace. The detection area comprises a plurality of first scan lines extending along a first direction, each of which being connected to the first pin area through a corresponding first scan trace; a plurality of first data lines extending along a second direction different from the first direction, each of which being connected to the second pin area through a corresponding first data trace; a plurality of detection units, each of which comprising a first switching transistor connected to a corresponding first scan line and data line, a driving electrode connected to the first switching transistor, and a first hydrophobic layer above the driving electrode. The grounding trace is connected to at least one detection unit and one of the plurality of pin areas.
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