-
公开(公告)号：EP2566864B1
公开(公告)日：2014-09-03
申请号：EP11718989.4
申请日：2011-05-06
发明人： GRAUERT, Matthias , BAKKER, Remko , BREITFELDER, Steffen , BUETTNER, Frank , EICKELMANN, Peter , FOX, Thomas , GRUNDL, Marc , LEHMANN-LINTZ, Thorsten , RIST, Wolfgang
IPC分类号： C07D413/04 , C07D413/14 , A61K31/501 , A61P3/00
CPC分类号： C07D413/10 , C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D498/04
-
2.发明授权Indanyloxydihydrobenzofuranylacetic acids useful for the treatment of metabolic syndrome 有权对于代谢综合征合适Indanyloxydihydrobenzofuranylessigsäuren的治疗
公开(公告)号：EP2646425B1
公开(公告)日：2015-06-10
申请号：EP11788845.3
申请日：2011-11-30
发明人： HIMMELSBACH, Frank , BAKKER, Remko , ECKHARDT, Matthias , HAMPRECHT, Dieter , LANGKOPF, Elke , WAGNER, Holger
IPC分类号： C07D307/80 , C07D405/12 , C07D407/12 , C07D413/12 , A61K31/343 , A61P3/10
CPC分类号： C07D307/80 , C07D405/12 , C07D407/12 , C07D413/12
-
3.发明公开
公开(公告)号：EP2646425A1
公开(公告)日：2013-10-09
申请号：EP11788845.3
申请日：2011-11-30
发明人： HIMMELSBACH, Frank , BAKKER, Remko , ECKHARDT, Matthias , HAMPRECHT, Dieter , LANGKOPF, Elke , WAGNER, Holger
IPC分类号： C07D307/80 , C07D405/12 , C07D407/12 , C07D413/12 , A61K31/343 , A61P3/10
CPC分类号： C07D307/80 , C07D405/12 , C07D407/12 , C07D413/12
摘要： The present invention relates to compounds defined by formula (I) wherein the variables R
1 , R
2 , R
3 , m, and n are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are activators of the receptor GPR40 and thus are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.-
公开(公告)号：EP3368529A1
公开(公告)日：2018-09-05
申请号：EP16784206.1
申请日：2016-10-20
发明人： FRATTINI, Sara , BAKKER, Remko , GIOVANNINI, Riccardo , HAMPRECHT, Dieter , LINGARD, Iain , PAUTSCH, Alexander , WELLENZOHN, Bernd
IPC分类号： C07D403/12 , A61K31/4155 , A61K31/4192 , A61P5/48 , A61P27/00
CPC分类号： C07D401/14 , A61K31/438 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D403/12 , C07D413/14
摘要： The present invention relates to compounds of general formula I, wherein D1 to D3, A, R1, R2, Y and n are defined as in claim 1, which have valuable pharmacological properties, in particular are inhibitors of plasma kallikrein. The compounds are suitable for treatment and prevention of diseases which can be influenced by influenced by inhibition of plasma kallikrein, such as diabetic complications, particularly in the treatment of retinal vascular permeability associated with diabetic retinopathy and diabetic macular edema.
-
公开(公告)号：EP3368524A1
公开(公告)日：2018-09-05
申请号：EP16784892.8
申请日：2016-10-20
发明人： FRATTINI, Sara , BAKKER, Remko , GIOVANNINI, Riccardo , FOSSATI, Giacomo , HAMPRECHT, Dieter , LINGARD, Iain , PAUTSCH, Alexander , WELLENZOHN, Bernd
IPC分类号： C07D401/14 , C07D471/04 , C07D487/04 , C07D491/052 , C07D498/04 , C07D498/10 , A61K31/435 , A61P3/10
CPC分类号： C07D401/14 , A61K45/06 , A61K2300/00 , A61P3/10 , C07D405/14 , C07D471/04 , C07D487/04 , C07D491/052 , C07D498/04 , C07D498/10
摘要： The present invention relates to compounds of general formula (I), wherein D 1 to D 3, -A-, n, R 1, R 2, Y 1, L and y2 are defined as in claim 1, which have valuable pharmacological properties, in particular are inhibitors of plasma kallikrein. The compounds are suitable for treatment and prevention of diseases which can be influenced by inhibition of plasma kallikrein, such as diabetic complications, particularly in the treatment of retinal vascular permeability associated with diabetic retinopathy and diabetic macular edema.
-
公开(公告)号：EP2566864A2
公开(公告)日：2013-03-13
申请号：EP11718989.4
申请日：2011-05-06
发明人： GRAUERT, Matthias , BAKKER, Remko , BREITFELDER, Steffen , BUETTNER, Frank , EICKELMANN, Peter , FOX, Thomas , GRUNDL, Marc , LEHMANN-LINTZ, Thorsten , RIST, Wolfgang
IPC分类号： C07D413/04 , C07D413/14 , A61K31/501 , A61P3/00
CPC分类号： C07D413/10 , C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D498/04
摘要： The present invention relates to pyridazinone derivatives of general formula (I), wherein the groups A, G and R
1 are as defined in the application, the tautomers thereof, stereoisomers thereof, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.019 秒)
