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公开(公告)号：EP3939577A1
公开(公告)日：2022-01-19
申请号：EP21189804.4
申请日：2008-08-15
发明人： DUGI, Klaus , MARK, Michael , THOMAS, Leo , HIMMELSBACH, Frank
IPC分类号： A61K31/00 , A61K31/70 , A61K31/7034 , A61K9/00 , A61K9/20 , A61K9/14 , A61K9/16 , A61K9/48 , A61P1/16 , A61P3/00 , A61P5/48 , A61P9/00 , A61P9/10 , A61P13/12 , A61P25/00 , A61P27/02 , A61P31/10 , A61P43/00 , A61P5/50 , A61P3/10 , A61P3/04 , A61P3/06
摘要： The invention relates to a pharmaceutical composition according to the claim 1 comprising a glucopyranosyl-substituted benzene derivative in combination with a DPP IV inhibitor which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.
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公开(公告)号：EP2820022B1
公开(公告)日：2018-01-03
申请号：EP13706034.9
申请日：2013-02-27
IPC分类号： C07D491/04 , A61K31/4355 , A61P3/00
CPC分类号： C07D491/044 , C07D491/04
摘要： The present invention relates to compounds of general formula I, wherein the groups R1, R2, and A are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
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3.发明授权ARYL- AND HETEROARYLCARBONYL DERIVATIVES OF BENZOMORPHANES AND RELATED SCAFFOLDS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE 有权芳和苯并吗吩烷和相关的基本框架，这些含药物及其使用HETEROARYLCARBONYLDERIVATE
公开(公告)号：EP2220048B1
公开(公告)日：2017-01-25
申请号：EP08850194.5
申请日：2008-11-14
发明人： HIMMELSBACH, Frank , ECKHARDT, Matthias , HAMILTON, Bradford S. , HECKEL, Armin , KLEY, Joerg , LEHMANN-LINTZ, Thorsten , NAR, Herbert , PETERS, Stefan , SCHULER-METZ, Annette , ZENTGRAF, Matthias
IPC分类号： C07D221/26 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D413/14 , C07D417/06 , C07D451/06 , C07D471/08 , C07D498/08 , A61K31/439 , A61P3/10
CPC分类号： C07D221/26 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D413/14 , C07D417/06 , C07D451/06 , C07D471/08 , C07D498/08
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4.发明公开PHARMACEUTICAL COMPOSITION COMPRISING A GLUCOPYRANOSYL-SUBSTITUTED BENZENE DERIVATIVE 审中-公开药剂师ZUSAMMENSETZUNG MIT EINEM GLUCOPYRANOSYL-SUBSTITUIERTEN BENZOLDERIVAT
公开(公告)号：EP3106156A1
公开(公告)日：2016-12-21
申请号：EP16172707.8
申请日：2008-08-15
发明人： DUGI, Klaus , MARK, Michael , THOMAS, Leo , HIMMELSBACH, Frank
IPC分类号： A61K31/00 , A61K31/70 , A61K31/7034 , A61K45/06 , A61K9/00 , A61K9/48 , A61K9/16 , A61K9/14 , A61K9/20 , A61P3/10 , A61P3/04 , A61P3/06
CPC分类号： A61K31/7034 , A61K9/0019 , A61K9/145 , A61K9/1623 , A61K9/2018 , A61K9/2072 , A61K9/4858 , A61K31/70 , A61K2300/00
摘要： The invention relates to a pharmaceutical composition according to the claim 1 comprising a glucopyranosyl-substituted benzene derivative in combination with a DPP IV inhibitor which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.
摘要翻译： 本发明涉及根据权利要求1的药物组合物，其包含与DPP IV抑制剂组合的吡喃葡萄糖基取代的苯衍生物，其适用于治疗或预防选自1型糖尿病，2型糖尿病的一种或多种病症 ，糖耐量异常和高血糖。 此外，本发明涉及用于预防或治疗代谢紊乱及相关病症的方法。
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5.发明授权PHARMACEUTICAL COMPOSITION COMPRISING A GLUCOPYRANOSYL-SUBSTITUTED BENZENE DERIVATIVE 有权包含吡喃酰基取代的苯衍生物的药物组合物
公开(公告)号：EP2187879B1
公开(公告)日：2016-10-12
申请号：EP08787264.4
申请日：2008-08-15
发明人： DUGI, Klaus , MARK, Michael , THOMAS, Leo , HIMMELSBACH, Frank
IPC分类号： A61K31/00 , A61K31/70 , A61K31/7034 , A61P3/10 , A61P3/04 , A61P3/06 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/48
CPC分类号： A61K31/7034 , A61K9/0019 , A61K9/145 , A61K9/1623 , A61K9/2018 , A61K9/2072 , A61K9/4858 , A61K31/70 , A61K2300/00
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公开(公告)号：EP3063148A1
公开(公告)日：2016-09-07
申请号：EP14789561.9
申请日：2014-10-27
发明人： WAGNER, Holger , HIMMELSBACH, Frank
IPC分类号： C07D471/04 , C07D493/04 , A61K31/437 , A61P3/10 , A61P3/04 , A61P9/10 , A61P9/12
CPC分类号： C07D471/04 , A61K31/437 , A61K31/5377 , A61K45/06 , C07D493/04
摘要： The present invention relates to compounds of general formula I, wherein the group R1, R2, X, Y and z are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
摘要翻译： 本发明涉及通式（I）的化合物，其中基团R 1，R 2，X，Y和z如权利要求1中所定义，其具有有价值的药理学性质，特别是与AMP-活化的蛋白激酶 （AMPK）并调节其活性。 该化合物适用于治疗和预防可受该受体影响的疾病，如代谢性疾病，特别是2型糖尿病。
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7.发明授权N-CYCLOPROPYL-N-PIPERIDINYL-AMIDE DERIVATIVES AND THEIR USE AS GPR119 MODULATORS 有权的N-环丙基-N-哌啶基 - 酰胺衍生物及其作为GPR119调节剂的
公开(公告)号：EP2877464B1
公开(公告)日：2016-08-24
申请号：EP13742183.0
申请日：2013-07-18
IPC分类号： C07D401/14 , C07D401/12 , C07D413/12 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/506 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： C07D413/12 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K45/06 , C07D401/12 , C07D401/14
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公开(公告)号：EP2844653B1
公开(公告)日：2016-02-17
申请号：EP13720889.8
申请日：2013-04-29
IPC分类号： C07D405/12 , A61K31/343 , A61K31/443 , C07D307/80 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： C07D307/80 , A61K31/343 , A61K31/443 , A61K45/06 , C07D405/12 , A61K2300/00
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公开(公告)号：EP2844653A1
公开(公告)日：2015-03-11
申请号：EP13720889.8
申请日：2013-04-29
IPC分类号： C07D405/12 , A61K31/343 , A61K31/443 , C07D307/80 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： C07D307/80 , A61K31/343 , A61K31/443 , A61K45/06 , C07D405/12 , A61K2300/00
摘要： The present invention relates to compounds of general formula (I), wherein the groups R
1 , R
2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.摘要翻译： 本发明涉及通式（I）的化合物，其中基团R 1，R 2和m如权利要求1中所定义，其具有有价值的药理学性质，特别是与GPR40受体结合并调节其活性。 该化合物适用于治疗和预防可受该受体影响的疾病，如代谢性疾病，特别是2型糖尿病。
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公开(公告)号：EP2820022A1
公开(公告)日：2015-01-07
申请号：EP13706034.9
申请日：2013-02-27
IPC分类号： C07D491/04 , A61K31/4355 , A61P3/00
CPC分类号： C07D491/044 , C07D491/04
摘要： The present invention relates to compounds of general formula I, wherein the groups R1, R2, and A are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译： 本发明涉及通式（I）的化合物，其中基团R 1，R 2和A如本申请中所定义，其具有有价值的药理学性质，并且特别是与GPR119受体结合并调节其活性 。
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