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公开(公告)号：EP3551638A2
公开(公告)日：2019-10-16
申请号：EP17818009.7
申请日：2017-12-06
发明人： DESROSIERS, Jean-Nicolas , FANDRICK, Daniel Robert , HADDAD, Nizar , LI, Guisheng , PATEL, Nitinchandra D. , QU, Bo , RODRIGUEZ, Sonia , SENANAYAKE, Chris Hugh , SIEBER, Joshua Daniel , TAN, Zhulin , WANG, Xiao-Jun , YEE, Nathan K. , ZHANG, Li , ZHANG, Yongda
IPC分类号： C07F9/6568 , C07B53/00 , C07F15/00
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公开(公告)号：EP2346868A1
公开(公告)日：2011-07-27
申请号：EP09792818.8
申请日：2009-09-22
发明人： COOK, Brian Nicholas , DISALVO, Darren , FANDRICK, Daniel Robert , HARCKEN, Christian , KUZMICH, Daniel , LEE, Thomas Wai-Ho , LIU, Pingrong , LORD, John , MAO, Can , NEU, Jochen , RAUDENBUSH, Brian Christopher , RAZAVI, Hossein , REEVES, Jonathan Timothy , SONG, Jinhua, J. , SWINAMER, Alan, David , TAN, Zhulin
IPC分类号： C07D471/04 , A61K31/4375 , A61P29/00
CPC分类号： C07D471/04
摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
摘要翻译： 公开了式（I）化合物，用于治疗通过CCR1活性介导或维持的多种疾病和病症，包括自身免疫性疾病如类风湿性关节炎和多发性硬化症。 还公开了制造方法和使用方法。
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公开(公告)号：EP2346868B1
公开(公告)日：2016-01-27
申请号：EP09792818.8
申请日：2009-09-22
发明人： COOK, Brian Nicholas , DISALVO, Darren , FANDRICK, Daniel Robert , HARCKEN, Christian , KUZMICH, Daniel , LEE, Thomas Wai-Ho , LIU, Pingrong , LORD, John , MAO, Can , NEU, Jochen , RAUDENBUSH, Brian Christopher , RAZAVI, Hossein , REEVES, Jonathan Timothy , SONG, Jinhua, J. , SWINAMER, Alan, David , TAN, Zhulin
IPC分类号： C07D471/04 , A61K31/4375 , A61P29/00
CPC分类号： C07D471/04
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公开(公告)号：EP2655349B1
公开(公告)日：2014-10-15
申请号：EP11810721.8
申请日：2011-12-15
发明人： FANDRICK, Daniel Robert , LU, Zhi-Hui , REEVES, Diane Crimhilda , REEVES, Jonathan Timothy , SENANAYAKE, Chris Hugh , SONG, Jinhua J. , ZHANG, Yongda
IPC分类号： C07D265/10 , C07C271/16
CPC分类号： C07D413/10 , C07C271/48 , C07D213/64 , C07D265/10
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公开(公告)号：EP2655349A1
公开(公告)日：2013-10-30
申请号：EP11810721.8
申请日：2011-12-15
发明人： FANDRICK, Daniel Robert , LU, Zhi-Hui , REEVES, Diane Crimhilda , REEVES, Jonathan Timothy , SENANAYAKE, Chris Hugh , SONG, Jinhua J. , ZHANG, Yongda
IPC分类号： C07D265/10 , C07C271/16
CPC分类号： C07D413/10 , C07C271/48 , C07D213/64 , C07D265/10
摘要： Disclosed is a process for making diastereomeric compound of the formula (I): wherein m, n and R
1 to R
4 are as defined herein. The process of the invention provides the compound of formula (I) in high yield and substantially free of the corresponding diastereomers. The compounds of formula (I) prepared by the process of the invention are useful for making pharmaceutically active compounds such as 11- β-hydroxysteroid hydrogenase type 1 (11- β-HSD1) inhibitors.
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