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公开(公告)号：EP2346868B1
公开(公告)日：2016-01-27
申请号：EP09792818.8
申请日：2009-09-22
发明人： COOK, Brian Nicholas , DISALVO, Darren , FANDRICK, Daniel Robert , HARCKEN, Christian , KUZMICH, Daniel , LEE, Thomas Wai-Ho , LIU, Pingrong , LORD, John , MAO, Can , NEU, Jochen , RAUDENBUSH, Brian Christopher , RAZAVI, Hossein , REEVES, Jonathan Timothy , SONG, Jinhua, J. , SWINAMER, Alan, David , TAN, Zhulin
IPC分类号： C07D471/04 , A61K31/4375 , A61P29/00
CPC分类号： C07D471/04
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公开(公告)号：EP2285822A1
公开(公告)日：2011-02-23
申请号：EP09743418.7
申请日：2009-05-05
CPC分类号： C07K5/0804 , C07K1/107
摘要： The present invention is directed to a method for the preparation of macrocyclic compounds of formula (I), comprising the step of cyclizing a diene of formula (II), in the presence of a catalyst, wherein R
1 -R
6 , A, W and V are as defined herein. The present invention is also directed to intermediate compounds of formula (II).-
公开(公告)号：EP2576570A1
公开(公告)日：2013-04-10
申请号：EP11724495.4
申请日：2011-05-23
发明人： TAN, Zhulin
IPC分类号： C07F5/02
CPC分类号： C07F5/025 , C07D413/10
摘要： The present invention relates to a compound of formula (I) wherein R
1 , R
2 and n are as defined herein. The invention also relates to processes for making the compounds of formula (I) and methods of using the compounds of formula (I) as reagents in organic synthesis.-
公开(公告)号：EP1945605B1
公开(公告)日：2013-01-09
申请号：EP06827396.0
申请日：2006-11-01
发明人： GALLOU, Fabrice , LEE, Heewon , SENANAYAKE, Chris, Hugh , SONG, Jinhua, J. , TAN, Zhulin , XU, Jinghua , YEE, Nathan, K.
IPC分类号： C07C213/02 , C07C249/08 , C07C251/44 , C07C217/84
CPC分类号： C07C213/02 , C07C249/08 , C07C251/44 , C07C2601/16 , C07C217/84
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5.发明授权
公开(公告)号：EP2280974B1
公开(公告)日：2012-01-25
申请号：EP09739539.6
申请日：2009-04-28
CPC分类号： C07B57/00 , C07D487/04
摘要： A process for stereoselective synthesis of a compound of Formula (I) wherein R
1 , R
2 , R
3 , R
4 , and R
5 are as described herein.-
6.发明公开
公开(公告)号：EP2280974A1
公开(公告)日：2011-02-09
申请号：EP09739539.6
申请日：2009-04-28
CPC分类号： C07B57/00 , C07D487/04
摘要： A process for stereoselective synthesis of a compound of Formula (I) wherein R
1 , R
2 , R
3 , R
4 , and R
5 are as described herein.-
7.发明公开STEREOSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS 有权某些TRIFLUORMETHYLSUBSTITUIERTER醇的立体选择性合成
公开(公告)号：EP1934218A1
公开(公告)日：2008-06-25
申请号：EP06803728.2
申请日：2006-09-18
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.
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公开(公告)号：EP3551638A2
公开(公告)日：2019-10-16
申请号：EP17818009.7
申请日：2017-12-06
发明人： DESROSIERS, Jean-Nicolas , FANDRICK, Daniel Robert , HADDAD, Nizar , LI, Guisheng , PATEL, Nitinchandra D. , QU, Bo , RODRIGUEZ, Sonia , SENANAYAKE, Chris Hugh , SIEBER, Joshua Daniel , TAN, Zhulin , WANG, Xiao-Jun , YEE, Nathan K. , ZHANG, Li , ZHANG, Yongda
IPC分类号： C07F9/6568 , C07B53/00 , C07F15/00
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公开(公告)号：EP2346868A1
公开(公告)日：2011-07-27
申请号：EP09792818.8
申请日：2009-09-22
发明人： COOK, Brian Nicholas , DISALVO, Darren , FANDRICK, Daniel Robert , HARCKEN, Christian , KUZMICH, Daniel , LEE, Thomas Wai-Ho , LIU, Pingrong , LORD, John , MAO, Can , NEU, Jochen , RAUDENBUSH, Brian Christopher , RAZAVI, Hossein , REEVES, Jonathan Timothy , SONG, Jinhua, J. , SWINAMER, Alan, David , TAN, Zhulin
IPC分类号： C07D471/04 , A61K31/4375 , A61P29/00
CPC分类号： C07D471/04
摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
摘要翻译： 公开了式（I）化合物，用于治疗通过CCR1活性介导或维持的多种疾病和病症，包括自身免疫性疾病如类风湿性关节炎和多发性硬化症。 还公开了制造方法和使用方法。
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10.发明授权STEREOSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS 有权某些TRIFLUORMETHYLSUBSTITUIERTER醇的立体选择性合成
公开(公告)号：EP1934218B1
公开(公告)日：2009-11-18
申请号：EP06803728.2
申请日：2006-09-18
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.
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