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1.发明公开
公开(公告)号：EP2217582A1
公开(公告)日：2010-08-18
申请号：EP08847937.3
申请日：2008-10-21
发明人： AVEN, Michael , SIEGER, Peter
IPC分类号： C07D265/36 , A61K31/538 , A61P11/00
CPC分类号： C07D265/36
摘要： The present invention relates to a crystalline, enantiomerically pure hydrate of R-6-hydroxy-8-{1-hydroxy-2-[2-(4-methoxy-phenyI)-1,1-dimethyl-ethylamino]-ethyl}-4H-benzo[1,4]oxazin-3-one-hydrochloride of formula (1) and its activity as a long-acting betamimetic, on its own or combined with one or more other active substances for treating respiratory complaints.
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2.发明公开ENANTIOMERENREINE BETAAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNGEN UND DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开对映异构β受体激动剂筹备工作他们的方法和它们作为药物
公开(公告)号：EP2057134A1
公开(公告)日：2009-05-13
申请号：EP07802746.3
申请日：2007-08-21
发明人： KONETZKI, Ingo , SIEGER, Peter
IPC分类号： C07D265/18 , A61K31/536 , A61P11/06 , A61P11/08
CPC分类号： C07D265/18
摘要： The invention relates to single enantiomer compounds of formula (1), where the groups R1, R2, R3, m and Ym- can have the meanings given in the claims and description, method for production and use thereof as a medicament, in particular as medicament for the treatment of airway diseases.
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3.发明公开
公开(公告)号：EP1891046A1
公开(公告)日：2008-02-27
申请号：EP06763468.3
申请日：2006-06-01
发明人： SIEGER, Peter , HAUEL, Norbert , SCHMID, Rolf , SOBOTTA, Rainer
IPC分类号： C07D401/12 , A61K31/4402 , A61K31/4184
CPC分类号： C07D401/12
摘要： The invention relates to novel polymorphs of the active ingredient ethyl 3-[(2-{[4-(hexyloxycarbonylamino-iminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-yl-amino]propionate, their preparation and their use as drugs.
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4.发明授权PROCESS FOR PREPARING TIOTROPIUM SALTS, TIOTROPIUM SALTS AS SUCH AND PHARMACEUTICAL COMPOSITIONS THEREOF 有权用于生产盐的噻托溴铵，噻托溴铵盐和药物化合物
公开(公告)号：EP1896026B1
公开(公告)日：2013-10-09
申请号：EP06763345.3
申请日：2006-05-30
IPC分类号： A61K31/46 , A61P11/00 , C07D451/10
CPC分类号： C07D451/00 , C07D451/10
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5.发明公开HYDROCHLORIDE UND HYDRATE VON 1-[(3-CYANO-PYRIDIN-2-YL) METHYL]-3-METHYL-7-(2-BUTIN-1-YL)-8-(3-AMINO-PIPERIDIN-1-YL)-XANTHIN, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权盐酸盐和水合物的1 - [（3-氰基 - 吡啶-2-基）甲基] -3-甲基-7-（2-丁炔-1-基）-8-（3-氨基 - 哌啶-1-基） 黄嘌呤，它们的制备及其作为药物
公开(公告)号：EP1912990A1
公开(公告)日：2008-04-23
申请号：EP06777973.6
申请日：2006-07-26
发明人： PFRENGLE, Waldemar , SIEGER, Peter
IPC分类号： C07D473/04 , A61K31/522 , A61P3/10
CPC分类号： C07D473/04
摘要： The invention relates to salts of 1-[(3-cyanopyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-aminopiperidin-1-yl]xanthine with hydrochloric acid, and also to their enantiomers, mixtures thereof and hydrates thereof.
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6.发明公开HYDRATE UND POLYMORPHE DES 4-[[(7R)-8-CYCLOPENTYL-7-ETHYL-5,6,7,8-TETRAHYDRO-5-METHYL-4-6-OXO-2-PIPERIDINYL|]AMINO]-3-METHOXY-N-(1-METHYL-4-PIPERIDINYL)-BENZAMID, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开水合物和4的多晶型物 - [[（7R）-8-环戊基-7-乙基-5,6,7,8-四氢-5-甲基4-6-氧代-2-哌啶基]氨基] -3-甲氧基 -N-（1-甲基-4-哌啶基） - 苯甲酰胺，其制备方法及其作为药物的用途
公开(公告)号：EP1778691A1
公开(公告)日：2007-05-02
申请号：EP05772062.5
申请日：2005-08-11
发明人： LINZ, Guenter , SIEGER, Peter , KRAEMER, Gerd, F. , RALL, Werner , HERTER, Rolf , HOFFMANN, Matthias , SCHMID, Rolf
IPC分类号： C07D475/00 , C07D211/58 , A61P35/00 , A61K31/519
CPC分类号： C07D211/58 , C07D475/00
摘要： The invention relates to novel hydrates and novel polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl) benzamide, methods for the production thereof, and the use thereof as medicaments.
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公开(公告)号：EP1678165B1
公开(公告)日：2013-09-25
申请号：EP04765927.1
申请日：2004-10-12
IPC分类号： C07D405/12 , A61K31/505 , A61P35/00
CPC分类号： C07D405/12
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公开(公告)号：EP1682543B1
公开(公告)日：2010-08-18
申请号：EP04791030.2
申请日：2004-10-29
IPC分类号： C07D451/10 , A61K31/46 , A61P11/00
CPC分类号： C07D451/10
摘要： The invention relates to novel tiotropium salts, methods for the production thereof, pharmaceutical formulations containing the same, and the use thereof for producing a medicament that is used for the treatment of respiratory diseases, especially COPD (chronic obstructive pulmonary disease) and asthma.
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9.发明公开PROCESS FOR THE SYNTHESIS OF DERIVATIVES OF 3-AMINO-TETRAHYDROFURAN-3-CARBOXYLIC ACID AND USE THEREOF AS MEDICAMENTS 审中-公开方法合成3-氨基 - 四氢呋喃-3-羧酸衍生物的和它们作为药物使用
公开(公告)号：EP2114909A2
公开(公告)日：2009-11-11
申请号：EP07866298.8
申请日：2007-12-21
发明人： HAN, Zhengxu , GERLACH, Kai , KRISHNAMURTHY, Dhileepkumar , MATTHES, Burkhard , NAR, Herbert , PRIEPKE, Henning , SCHULER-METZ, Annette , SENANAYAKE, Chris H. , SIEGER, Peter , TANG, Wenjun , WIENEN, Wolfgang , XU, Yibo , YEE, Nathan K.
IPC分类号： C07D307/24 , C07D409/14 , C07D413/14
CPC分类号： C07D409/14 , C07D307/24 , C07D413/14
摘要： The present invention relates to a process for the manufacturing of substituted 3- amino-tetrahydrofuran-3-carboxylic acid amides of general formula (I) and their precursors in high optical purity to the precursors of the synthesis of substituted S-Amino-tetrahydrofuran-S-carboxylic acid amides of general formula (I) in high optical purity, and to the tautomers, enantiomers, diastereomers, mixtures and salts of substituted 3-amino- tetrahydrofuran-3-carboxylic acid amides of general formula (I) in high optical purity, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
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10.发明公开ENANTIOMERENREINE BETAAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开对映异构β受体激动剂，方法及其及其作为药物
公开(公告)号：EP2057152A1
公开(公告)日：2009-05-13
申请号：EP07788189.4
申请日：2007-08-03
IPC分类号： C07D413/12 , C07D413/14 , A61P11/00 , A61K31/538
CPC分类号： C07D413/12 , C07D413/14
摘要： The present invention relates to single enantiomer compounds of formula (1), where the moieties n, A, R1, R2, R3, m, and Y can have the meanings stated in the claims and in the description, methods for the production thereof, and the use thereof as medication, in particular as medication to treat diseases of the respiratory tract.
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