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1.发明授权NEUE 3-METHYL-7-BUTINYL-XANTHINE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权NEW 3-甲基-7-丁炔基 - 黄嘌呤，它们的制备和它们作为药物
公开(公告)号：EP1797093B1
公开(公告)日：2012-05-30
申请号：EP05781895.7
申请日：2005-09-09
发明人： LANGKOPF, Elke , ECKHARDT, Matthias , HIMMELSBACH, Frank , TADAYYON, Mohammad , THOMAS, Leo , LOTZ, Ralf, R., H.
IPC分类号： C07D473/04 , A61P3/10 , A61K31/4985
CPC分类号： C07D473/00
摘要： The invention relates to novel substituted xanthines of general formula (I), wherein R1, R2, and X are defined as mentioned in the claims, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof, which have valuable pharmaceutical properties, especially an inhibitive effect on the activity of the dipeptidyl peptidase-IV (DPP-IV) enzyme.
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2.发明授权
公开(公告)号：EP1761517B1
公开(公告)日：2014-09-24
申请号：EP05758460.9
申请日：2005-06-18
IPC分类号： C07D401/04 , A61K31/4196 , A61P3/10
CPC分类号： C07D471/04 , C07D249/14 , C07D401/04 , C07D401/12 , C07D401/14
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3.发明授权8-[3-AMINO-PIPERIDIN-1-YL] -XANTHINE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权8- [3-氨基 - 哌啶-1-基] -xanthines，其制备方法及其作为药物的用途
公开(公告)号：EP1532149B1
公开(公告)日：2009-12-30
申请号：EP03792359.6
申请日：2003-08-18
发明人： HIMMELSBACH, Frank , LANGKOPF, Elke , ECKHARDT, Matthias , MARK, Michael , MAIER, Roland , LOTZ, Ralf, Richard, Hermann , TADAYYON, Mohammad
IPC分类号： C07D473/04 , A61K31/522 , A61P3/10
CPC分类号： A61K9/2866 , A61K9/0095 , A61K9/02 , A61K9/2018 , A61K9/4858 , A61K47/02 , C07D473/04
摘要： The invention relates to substituted xanthines of general formula (I) wherein R1 to R3 have the designations cited in patent claims 1 to 16, and to the tautomers, stereoisomers, mixtures, prodrugs and salts thereof, which have precious pharmacological properties, especially an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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公开(公告)号：EP1641799B8
公开(公告)日：2008-10-08
申请号：EP04736644.8
申请日：2004-06-11
发明人： ECKHARDT, Matthias , HAUEL, Norbert , LANGKOPF, Elke , HIMMELSBACH, Frank , KAUFFMANN-HEFNER, Iris , TADAYYON, Mohammad , MARK, Michael
IPC分类号： C07D487/04 , C07D471/04 , C07D519/00 , A61K31/5025 , A61P3/10
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula (I), wherein Y and R1 to R4 are defined as indicated in claim 1, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof that have valuable pharmacological properties, especially an inhibiting effect on the activity of the dipeptidyl peptidase IV (DPP-IV) enzyme.
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5.发明公开8-(3-AMINO-PIPERIDIN-1-YL)-7-(BUT-2-INYL)-XANTHINE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开8-（3-氨基 - 哌啶-1-基）-7-（丁-2-炔基）-xanthines，其制备方法及其作为药物的用途
公开(公告)号：EP1791844A1
公开(公告)日：2007-06-06
申请号：EP05790339.5
申请日：2005-09-06
IPC分类号： C07D473/04 , A61K31/437 , A61P3/10
CPC分类号： C07D473/06 , C07D473/04
摘要： The invention relates to substituted xanthines of general formula (I), wherein R1 and R2 have the meaning cited in claims 1 to 11. The invention also relates to the tautomers, enantiomers, diastereomers, mixtures and salts thereof, which have valuable pharmacological properties, especially an inhibiting action on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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6.发明公开IMIDAZOPYRIDAZINDIONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开IMIDAZOPYRIDAZINDIONE，其制备及其作为药物
公开(公告)号：EP1763530A1
公开(公告)日：2007-03-21
申请号：EP05728980.3
申请日：2005-03-09
发明人： ECKHARDT, Matthias , HIMMELSBACH, Frank , LANGKOPF, Elke , KAUFFMANN-HEFNER, Iris , TADAYYON, Mohammad , THOMAS, Leo
IPC分类号： C07D487/04 , A61K31/5025 , A61P5/50
CPC分类号： C07D519/00 , C07D487/04
摘要： The invention relates to substituted imidazopyridazine diones of general formula (I) wherein R1 to R4 have the designation defined in patent claim 1. The invention also relates to the tautomers, enantiomers, diastereomers, mixtures and salts of said diones, comprising valuable pharmacological properties, especially an inhibitive effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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7.发明公开NEUE 2-AMINO-IMIDAZO[4,5-D]PYRIDAZIN-4-ONE UND 2-AMINO-IMIDAZO[4,5-C]PYRIDIN-4-ONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开NEW 2-氨基 - 咪唑并[4,5-d]哒嗪-4-酮和2-氨基咪唑并[4,5-c]吡啶-4-酮，其制备方法及其作为药物的用途
公开(公告)号：EP1740589A1
公开(公告)日：2007-01-10
申请号：EP05716507.8
申请日：2005-04-02
发明人： ECKHARDT, Matthias , HIMMELSBACH, Frank , LANGKOPF, Elke , HAUEL, Norbert , TADAYYON, Mohammad , THOMAS, Leo
IPC分类号： C07D487/04 , C07D471/04 , A61K31/437 , A61K31/5025 , A61P3/10
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to 2-amino-imidazo[4,5-d]pyridazin-4-ones and 2-amino-imidazo[4,5-c]pyridin-4-ones of general formula (I), where R1 to R4 and X are as defined in claims 1 to 6, the tautomers, enantiomers, diastereomers, mixtures and salts thereof with useful pharmacological properties, in particular an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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8.发明公开NEUE SUBSTITUIERTE IMIDAZO-PYRIDINONE UND IMIDAZO-PYRIDAZINONE, IHRE HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权新的取代咪唑吡啶酮和咪唑并 - 哒嗪酮，生产及其作为药物
公开(公告)号：EP1569936A1
公开(公告)日：2005-09-07
申请号：EP03789123.1
申请日：2003-12-03
发明人： HAUEL, Norbert , HIMMELSBACH, Frank , LANGKOPF, Elke , ECKHARDT, Matthias , MAIER, Roland , MARK, Michael , TADAYYON, Mohammad , KAUFFMANN-HEFNER, Iris
IPC分类号： C07D487/04 , A61P5/48
CPC分类号： C07D471/04 , A61K9/0019 , A61K9/0031 , A61K9/0095 , A61K9/02 , A61K9/10 , A61K9/2018 , A61K9/2072 , A61K9/2086 , A61K9/2866 , A61K9/4866 , C07D487/04
摘要： The invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula (I) wherein R1 - R4 are defined as in Claim, the tautomers thereof, the stereoisomers thereof, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, especially an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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9.发明公开8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权8- [3-氨基 - 哌啶-1-基] -xanthines，其制备方法及其作为药物的用途
公开(公告)号：EP1532149A2
公开(公告)日：2005-05-25
申请号：EP03792359.6
申请日：2003-08-18
发明人： HIMMELSBACH, Frank , LANGKOPF, Elke , ECKHARDT, Matthias , MARK, Michael , MAIER, Roland , LOTZ, Ralf, Richard, Hermann , TADAYYON, Mohammad
IPC分类号： C07D473/04 , A61K31/522 , A61P3/10
CPC分类号： A61K9/2866 , A61K9/0095 , A61K9/02 , A61K9/2018 , A61K9/4858 , A61K47/02 , C07D473/04
摘要： The invention relates to substituted xanthines of general formula (I) wherein R1 to R3 have the designations cited in patent claims 1 to 16, and to the tautomers, stereoisomers, mixtures, prodrugs and salts thereof, which have precious pharmacological properties, especially an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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10.发明授权8-[3-AMINO-PIPERIDIN-1-YL] -XANTHINE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权8- [3-氨基 - 哌啶-1-基] -xanthines，其制备方法及其作为药物的用途
公开(公告)号：EP1532149B9
公开(公告)日：2011-04-20
申请号：EP03792359.6
申请日：2003-08-18
发明人： HIMMELSBACH, Frank , LANGKOPF, Elke , ECKHARDT, Matthias , MARK, Michael , MAIER, Roland , LOTZ, Ralf, Richard, Hermann , TADAYYON, Mohammad
IPC分类号： C07D473/04 , A61K31/522 , A61P3/10
CPC分类号： A61K9/2866 , A61K9/0095 , A61K9/02 , A61K9/2018 , A61K9/4858 , A61K47/02 , C07D473/04
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