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1.发明授权GLUCOPYRANOSYL-SUBSTITUTED BENZONITRILE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE 有权吡喃葡萄糖基取代苯甲腈衍生物，这样的化合物的药物组合物，它们的使用及其制造方法
公开(公告)号：EP2024352B1
公开(公告)日：2013-04-24
申请号：EP07728702.7
申请日：2007-05-02
IPC分类号： C07D309/10 , A61K31/351
CPC分类号： C07H7/04 , A61K9/0019 , A61K9/02 , A61K9/2018 , A61K9/4866 , C07D309/10
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2.发明授权NEUE 3-METHYL-7-BUTINYL-XANTHINE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权NEW 3-甲基-7-丁炔基 - 黄嘌呤，它们的制备和它们作为药物
公开(公告)号：EP1797093B1
公开(公告)日：2012-05-30
申请号：EP05781895.7
申请日：2005-09-09
发明人： LANGKOPF, Elke , ECKHARDT, Matthias , HIMMELSBACH, Frank , TADAYYON, Mohammad , THOMAS, Leo , LOTZ, Ralf, R., H.
IPC分类号： C07D473/04 , A61P3/10 , A61K31/4985
CPC分类号： C07D473/00
摘要： The invention relates to novel substituted xanthines of general formula (I), wherein R1, R2, and X are defined as mentioned in the claims, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof, which have valuable pharmaceutical properties, especially an inhibitive effect on the activity of the dipeptidyl peptidase-IV (DPP-IV) enzyme.
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3.发明授权CRYSTALLINE FORM OF 1-CHLORO-4-(ß-D-GLUCOPYRANOS-1-YL)-2-[4-((S)-TETRAHYDROFURAN-3-YLOXY)-BENZYL]-BENZENE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS 有权的结晶形式的1-氯-4-（β-D-吡喃葡萄糖-1-基）-2- [4 - （（S） - 四氢呋喃-3-基氧基） - 苄基] - 苯，其制造方法及其使用 生产药物的
公开(公告)号：EP1888552B1
公开(公告)日：2009-12-23
申请号：EP06763074.9
申请日：2006-05-02
发明人： ECKHARDT, Matthias , HIMMELSBACH, Frank , SICK, Sandra , SCHUEHLE, Martin , MARTIN, Hans-Jürgen
IPC分类号： C07D309/10 , A61K31/351
CPC分类号： C07H15/00 , C07D405/12
摘要： The invention relates to a crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((Sj-tetrahydrofuran-3-yloxy)-benzyl]-benzene, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
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4.发明公开GLUCOPYRANOSYL-SUBSTITUTED DIFLUOROBENZYL-BENZENE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE 审中-公开吡喃葡萄糖基取代二氟苄苯衍生物，用这类化合物的药物，它们的用途及其制造方法
公开(公告)号：EP2074130A1
公开(公告)日：2009-07-01
申请号：EP07820370.0
申请日：2007-09-20
IPC分类号： C07H7/04 , C07D309/10 , A61K31/70
CPC分类号： C07H7/04 , C07D309/10
摘要： Glucopyranosyl-substituted difluorobenzyl-benzene derivatives of general formula (I) as defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
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5.发明公开GLUCOPYRANOSYL-SUBSTITUTED CYCLOPROPYLBENZENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, THEIR USE AS SGLT INHIBITORS AND PROCESS FOR THEIR MANUFACTURE 审中-公开GLUCOPYRANOSYLSUBSTITUIERTE CYCLOPROPYLBENZOLDERIVATE，药物组合物这样的化合物，它们作为SGLT抑制剂及其制造方法的
公开(公告)号：EP2054426A1
公开(公告)日：2009-05-06
申请号：EP07788403.9
申请日：2007-08-14
CPC分类号： C07H7/06
摘要： Glucopyranosyl-substituted cyclopropyl-benzene derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
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6.发明公开CRYSTALLINE FORMS OF 1-CHLORO-4-(BETA-D-GLUCOPYRANOS-1-YL)-2-[4-((R)-TETRAHYDROFURAN-3-YLOXY)-BENZYL]-BENZENE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS 有权的结晶形式的1-氯-4-（β-D-吡喃葡萄糖-1-基）-2- [4 - （（R） - 四氢呋喃-3-基氧基） - 苄基] - 苯，其制备方法及其用于制造药用
公开(公告)号：EP1888551A1
公开(公告)日：2008-02-20
申请号：EP06754943.6
申请日：2006-05-02
发明人： ECKHARDT, Matthias , HIMMELSBACH, Frank , SICK, Sandra , SCHUEHLE, Martin , MARTIN, Hans-Jürgen
IPC分类号： C07D309/10 , A61K31/351
CPC分类号： C07D309/10 , C07D407/12
摘要： The invention relates to crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4- ((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
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7.发明授权D-XYLOPYRANOSYL-SUBSTITUIERTE PHENYLE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 有权D-D-吡喃木糖基 - 取代的苯基，药物含有它们，它们的用途和方法FOR THEIR
公开(公告)号：EP1765842B1
公开(公告)日：2008-01-09
申请号：EP05755962.7
申请日：2005-06-30
发明人： ECKHARDT, Matthias , HIMMELSBACH, Frank , EICKELMANN, Peter , THOMAS, Leo , BARSOUMIAN, Edward, Leon
摘要： The invention relates to D-xylopyranosyl-substituted phenyls of general formula (I) wherein the radicals R
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8.发明公开GLUCOPYRANOSYL-SUBSTITUTED ((HETERO)ARYLETHYNYL-BENZYL)-BENZENE DERIVATIVES AND USE THEREOF AS SODIUM-DEPENDENT GLUCOSE COTRANSPORTER 2 (SGLT2) INHIBITORS 有权GLUCOPYRANOSYLSUBSTITUIERTE（（杂）芳基乙炔 - 苄基）-BENZENDERIVATIVE及其作为钠依赖性葡萄糖协同转运蛋白2型抑制剂（SGLT2）
公开(公告)号：EP1856082A1
公开(公告)日：2007-11-21
申请号：EP06708381.6
申请日：2006-02-20
发明人： HIMMELSBACH, Frank , ECKHARDT, Matthias , EICKELMANN, Peter , THOMAS, Leo , BARSOUMIAN, Edward Leon
IPC分类号： C07D309/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K31/351 , A61K31/381 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/443 , A61K31/506 , A61K31/501
CPC分类号： C07D309/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： Glucopyranosyl-substituted (hetero)arylethynyl-benzene derivatives of the general formula (I) where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are SGLT2 inhibitors suitable for the treatment of metabolic disorders.
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9.发明公开D-PYRANOSYL-SUBSTITUIERTE PHENYLE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 有权D-吡喃取代的苯基，药物含有它们，它们的用途和方法FOR THEIR
公开(公告)号：EP1797107A2
公开(公告)日：2007-06-20
申请号：EP05797250.7
申请日：2005-09-28
发明人： ECKHARDT, Matthias , HIMMELSBACH, Frank , EICKELMANN, Peter , THOMAS, Leo , BARSOUMIAN, Edward Leon
IPC分类号： C07H7/04
CPC分类号： C07H7/04
摘要： Disclosed are D-pyranosyl-substituted phenyls of general formula (I), wherein the radicals R1 to R5, X, Z, and R7a, R7b, R7c are defined as indicated in claim 1. Said phenyls have an inhibitory effect on the sodium-dependent glucose cotransporter SGLT. The invention further relates to medicaments for treating metabolism disorders.
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10.发明公开METHYLIDEN-D-XYLOPYRANOSYL- UND OXO-D-XYLOPYRANOSYL-SUBSTITUIERTE PHENYLE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 审中-公开亚甲基-D-xylopyranosyl-和氧代-D吡喃木糖 - 取代的苯基，药物含有它们，它们的用途和方法FOR THEIR
公开(公告)号：EP1771460A1
公开(公告)日：2007-04-11
申请号：EP05771787.8
申请日：2005-07-13
发明人： ECKHARDT, Matthias , HIMMELSBACH, Frank , EICKELMANN, Peter , THOMAS, Leo , BARSOUMIAN, Edward Leon
CPC分类号： C07H7/04
摘要： D-xylopyranosyl-substituted phenyls of general formula (I), in which radicals R1 to R5, X, Z as well as R7a, R7b and R7c are defined as in Claim 1, exhibit an inhibiting effect upon the sodium-dependent glucose-cotransporter SGLT. The invention also relates to medicaments for treating metabolic diseases.
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