公开(公告)号：EP3221337A4

公开(公告)日：2018-05-02

申请号：EP15860430

申请日：2015-11-23

申请人： BOVIN NICOLAI VLADIMIROVICH ,  HENRY STEPHEN MICHEAL ,  KORCHAGINA ELENA YURIEVNA ,  RODIONOV IGOR LEONIDOVICH ,  TUZIKOV ALEXANDER BORISOVICH

发明人： BOVIN NICOLAI VLADIMIROVICH ,  HENRY STEPHEN MICHEAL ,  KORCHAGINA ELENA YURIEVNA ,  RODIONOV IGOR LEONIDOVICH ,  TUZIKOV ALEXANDER BORISOVICH

IPC分类号： C07K14/00 ,  A61K31/683 ,  A61K31/7004 ,  A61K31/702 ,  A61K38/16 ,  C07F9/10 ,  C07H15/04 ,  C07K7/06 ,  C07K7/08

CPC分类号： C07K9/00 ,  A61K31/685 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/702 ,  A61K38/00 ,  A61K47/555 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001

摘要： Water dispersible, multivalent ligand-lipid constructs that spontaneously and stably incorporate into membranes are disclosed.

公开(公告)号：EP2675487A4

公开(公告)日：2016-05-18

申请号：EP12755058

申请日：2012-02-09

申请人： BOVIN NICOLAI VLADIMIROVICH ,  HENRY STEPHEN MICHEAL ,  KORCHAGINA ELENA YURIEVNA ,  RODIONOV IGOR LEONIDOVICH ,  TUZIKOV ALEXANDER BORISOVICH

发明人： BOVIN NICOLAI VLADIMIROVICH ,  HENRY STEPHEN MICHEAL ,  KORCHAGINA ELENA YURIEVNA ,  RODIONOV IGOR LEONIDOVICH ,  TUZIKOV ALEXANDER BORISOVICH

IPC分类号： A61K51/04 ,  A61K51/06 ,  A61K51/08 ,  C07F9/09 ,  C07F9/10

CPC分类号： A61K51/08 ,  A61K51/0408 ,  A61K51/088 ,  C07F9/10 ,  C07K7/08

摘要： Non-invasive method of monitoring by radioactivity bioscanning the distribution of a biological entity in a subject in vivo by administering to the subject a radioiodinated form of the biological entity. The radioiodinated form is prepared by contacting an aqueous suspension of the biological entity with a radioiodinated construct of the structure F-S-L where F comprises a radioiodinated tyrosine moiety, S is a spacer covalently linking F to L, and L is a lipid.

公开(公告)号：EP2795316A4

公开(公告)日：2015-07-01

申请号：EP12880480

申请日：2012-12-19

申请人： HENRY STEPHEN MICHEAL ,  PARKER STEPHEN ROBERT

发明人： HENRY STEPHEN MICHEAL ,  PARKER STEPHEN ROBERT

IPC分类号： G01N33/48 ,  G01N33/53 ,  G01N33/543

CPC分类号： G01N1/4077 ,  B01D65/08 ,  C08G64/42 ,  C12Q1/02 ,  C12Q1/24 ,  G01N33/54353 ,  G01N33/54393 ,  G01N2001/4088

摘要： Biocompatible methods of functionalising inert surfaces for use in biological applications are described. The methods employ the use of synthetic constructs of the generic structure F-S-L (where F is a functional moiety, S is a spacer selected to provide a construct that is dispersible in water, and L is a diacyl- or dialkyl-glycerophospholipid). An object of the invention is to localise or immobilise functional moieties to the inert surface of a substrate wherein the surface is comprised of glass, silver, polyamide, polycarbonate, polypropylene, polyethersulfone, polytetrafluoroethylene or polyvinylidene fluoride, and the substrate is comprised of a fibre, membrane, microsphere or nanosphere.

摘要翻译： 描述了用于生物应用的功能化惰性表面的生物相容性方法。 该方法采用通用结构F-S-L的合成构建体（其中F是功能部分，S是选择用于提供可分散在水中的构建体，L是二酰基或二烷基 - 甘油磷脂）的间隔物。 本发明的目的是将功能部分定位或固定在基材的惰性表面上，其中表面由玻璃，银，聚酰胺，聚碳酸酯，聚丙烯，聚醚砜，聚四氟乙烯或聚偏二氟乙烯组成，基材由纤维 ，膜，微球或纳米球。

公开(公告)号：EP2449386A4

公开(公告)日：2013-11-13

申请号：EP10794415

申请日：2010-06-29

申请人： BOVIN NIKOLAI VLADIMIROVICH ,  HENRY STEPHEN MICHEAL ,  PARKER STEPHEN ROBERT

发明人： BOVIN NIKOLAI VLADIMIROVICH ,  HENRY STEPHEN MICHEAL ,  PARKER STEPHEN ROBERT

IPC分类号： G01N33/80

CPC分类号： G01N33/5308 ,  G01N33/92

摘要： Methods of manufacturing cards, strips and multiwell plates for use in diagnostic assays are described. The methods employ the use of synthetic constructs of the generic structure F-S-L (where F is an antigen for a reactive antibody, S is a spacer covalently linking F to L, and L is a lipid) as “ink” in inkjet printers. The cards, strips and multiwell plates provide a number of advantages including efficiency of manufacture and improved accuracy in determining and recording assay results.