公开(公告)号：EP2675487B1

公开(公告)日：2018-10-17

申请号：EP12755058.0

申请日：2012-02-09

申请人： Bovin, Nicolai Vladimirovich ,  Henry, Stephen Micheal ,  Korchagina, Elena Yurievna ,  Rodionov, Igor Leonidovich ,  Tuzikov, Alexander Borisovich

发明人： Bovin, Nicolai Vladimirovich ,  Henry, Stephen Micheal ,  Korchagina, Elena Yurievna ,  Rodionov, Igor Leonidovich ,  Tuzikov, Alexander Borisovich

IPC分类号： A61K51/04 ,  A61K51/08 ,  A61K51/06 ,  C07F9/09 ,  C07F9/10

CPC分类号： C07K7/08 ,  A61K51/0408 ,  A61K51/08 ,  A61K51/088 ,  C07F9/10

摘要： Non-invasive method of monitoring by radioactivity bioscanning the distribution of a biological entity in a subject in vivo by administering to the subject a radioiodinated form of the biological entity. The radioiodinated form is prepared by contacting an aqueous suspension of the biological entity with a radioiodinated construct of the structure F-S-L where F comprises a radioiodinated tyrosine moiety, S is a spacer covalently linking F to L, and L is a lipid.

公开(公告)号：EP2201025A1

公开(公告)日：2010-06-30

申请号：EP08836952.5

申请日：2008-10-13

申请人： Bovin, Nicolai ,  Henry, Stephen Micheal ,  Rodinov, Igor ,  Weinberg, Cristina-Simona

发明人： Bovin, Nicolai ,  Henry, Stephen Micheal ,  Rodinov, Igor ,  Weinberg, Cristina-Simona

IPC分类号： C07K7/06 ,  C07K7/08 ,  C07F9/10 ,  C07H15/04 ,  A61K38/08 ,  A61K38/10 ,  A61K31/685 ,  A61K31/7032 ,  G01N33/80 ,  C07K1/00

CPC分类号： C07K7/02 ,  A61K47/544 ,  A61K47/65 ,  C07F9/106 ,  C07F9/5721 ,  C07F9/6561 ,  C07K5/02 ,  C07K7/06 ,  C07K7/08 ,  G01N33/80

摘要： The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.

公开(公告)号：EP3221337A4

公开(公告)日：2018-05-02

申请号：EP15860430

申请日：2015-11-23

申请人： BOVIN NICOLAI VLADIMIROVICH ,  HENRY STEPHEN MICHEAL ,  KORCHAGINA ELENA YURIEVNA ,  RODIONOV IGOR LEONIDOVICH ,  TUZIKOV ALEXANDER BORISOVICH

发明人： BOVIN NICOLAI VLADIMIROVICH ,  HENRY STEPHEN MICHEAL ,  KORCHAGINA ELENA YURIEVNA ,  RODIONOV IGOR LEONIDOVICH ,  TUZIKOV ALEXANDER BORISOVICH

IPC分类号： C07K14/00 ,  A61K31/683 ,  A61K31/7004 ,  A61K31/702 ,  A61K38/16 ,  C07F9/10 ,  C07H15/04 ,  C07K7/06 ,  C07K7/08

CPC分类号： C07K9/00 ,  A61K31/685 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/702 ,  A61K38/00 ,  A61K47/555 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001

摘要： Water dispersible, multivalent ligand-lipid constructs that spontaneously and stably incorporate into membranes are disclosed.

公开(公告)号：EP3221337A1

公开(公告)日：2017-09-27

申请号：EP15860430.6

申请日：2015-11-23

申请人： Bovin, Nicolai Vladimirovich ,  Henry, Stephen Micheal ,  Korchagina, Elena Yurievna ,  Rodionov, Igor Leonidovich ,  Tuzikov, Alexander Borisovich

发明人： Bovin, Nicolai Vladimirovich ,  Henry, Stephen Micheal ,  Korchagina, Elena Yurievna ,  Rodionov, Igor Leonidovich ,  Tuzikov, Alexander Borisovich

IPC分类号： C07K14/00 ,  C07H15/04 ,  C07F9/10 ,  A61K38/16 ,  A61K31/683 ,  A61K31/7004 ,  A61K31/702

CPC分类号： C07K9/00 ,  A61K31/685 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/702 ,  A61K38/00 ,  A61K47/555 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001

摘要： Water dispersible, multivalent ligand-lipid constructs that spontaneously and stably incorporate into membranes are disclosed.

摘要翻译： 公开了自发并稳定地结合到膜中的水分散性多价配体 - 脂质构建体。

公开(公告)号：EP2675487A4

公开(公告)日：2016-05-18

申请号：EP12755058

申请日：2012-02-09

申请人： BOVIN NICOLAI VLADIMIROVICH ,  HENRY STEPHEN MICHEAL ,  KORCHAGINA ELENA YURIEVNA ,  RODIONOV IGOR LEONIDOVICH ,  TUZIKOV ALEXANDER BORISOVICH

发明人： BOVIN NICOLAI VLADIMIROVICH ,  HENRY STEPHEN MICHEAL ,  KORCHAGINA ELENA YURIEVNA ,  RODIONOV IGOR LEONIDOVICH ,  TUZIKOV ALEXANDER BORISOVICH

IPC分类号： A61K51/04 ,  A61K51/06 ,  A61K51/08 ,  C07F9/09 ,  C07F9/10

CPC分类号： A61K51/08 ,  A61K51/0408 ,  A61K51/088 ,  C07F9/10 ,  C07K7/08

摘要： Non-invasive method of monitoring by radioactivity bioscanning the distribution of a biological entity in a subject in vivo by administering to the subject a radioiodinated form of the biological entity. The radioiodinated form is prepared by contacting an aqueous suspension of the biological entity with a radioiodinated construct of the structure F-S-L where F comprises a radioiodinated tyrosine moiety, S is a spacer covalently linking F to L, and L is a lipid.

公开(公告)号：EP2449386A4

公开(公告)日：2013-11-13

申请号：EP10794415

申请日：2010-06-29

申请人： BOVIN NIKOLAI VLADIMIROVICH ,  HENRY STEPHEN MICHEAL ,  PARKER STEPHEN ROBERT

发明人： BOVIN NIKOLAI VLADIMIROVICH ,  HENRY STEPHEN MICHEAL ,  PARKER STEPHEN ROBERT

IPC分类号： G01N33/80

CPC分类号： G01N33/5308 ,  G01N33/92

摘要： Methods of manufacturing cards, strips and multiwell plates for use in diagnostic assays are described. The methods employ the use of synthetic constructs of the generic structure F-S-L (where F is an antigen for a reactive antibody, S is a spacer covalently linking F to L, and L is a lipid) as “ink” in inkjet printers. The cards, strips and multiwell plates provide a number of advantages including efficiency of manufacture and improved accuracy in determining and recording assay results.

公开(公告)号：EP2795316A4

公开(公告)日：2015-07-01

申请号：EP12880480

申请日：2012-12-19

申请人： HENRY STEPHEN MICHEAL ,  PARKER STEPHEN ROBERT

发明人： HENRY STEPHEN MICHEAL ,  PARKER STEPHEN ROBERT

IPC分类号： G01N33/48 ,  G01N33/53 ,  G01N33/543

CPC分类号： G01N1/4077 ,  B01D65/08 ,  C08G64/42 ,  C12Q1/02 ,  C12Q1/24 ,  G01N33/54353 ,  G01N33/54393 ,  G01N2001/4088

摘要： Biocompatible methods of functionalising inert surfaces for use in biological applications are described. The methods employ the use of synthetic constructs of the generic structure F-S-L (where F is a functional moiety, S is a spacer selected to provide a construct that is dispersible in water, and L is a diacyl- or dialkyl-glycerophospholipid). An object of the invention is to localise or immobilise functional moieties to the inert surface of a substrate wherein the surface is comprised of glass, silver, polyamide, polycarbonate, polypropylene, polyethersulfone, polytetrafluoroethylene or polyvinylidene fluoride, and the substrate is comprised of a fibre, membrane, microsphere or nanosphere.

摘要翻译： 描述了用于生物应用的功能化惰性表面的生物相容性方法。 该方法采用通用结构F-S-L的合成构建体（其中F是功能部分，S是选择用于提供可分散在水中的构建体，L是二酰基或二烷基 - 甘油磷脂）的间隔物。 本发明的目的是将功能部分定位或固定在基材的惰性表面上，其中表面由玻璃，银，聚酰胺，聚碳酸酯，聚丙烯，聚醚砜，聚四氟乙烯或聚偏二氟乙烯组成，基材由纤维 ，膜，微球或纳米球。

公开(公告)号：EP2675487A1

公开(公告)日：2013-12-25

申请号：EP12755058.0

申请日：2012-02-09

申请人： Bovin, Nicolai Vladimirovich ,  Henry, Stephen Micheal ,  Korchagina, Elena Yurievna ,  Rodionov, Igor Leonidovich ,  Tuzikov, Alexander Borisovich

发明人： Bovin, Nicolai Vladimirovich ,  Henry, Stephen Micheal ,  Korchagina, Elena Yurievna ,  Rodionov, Igor Leonidovich ,  Tuzikov, Alexander Borisovich

IPC分类号： A61K51/06 ,  C07F9/09

CPC分类号： C07K7/08 ,  A61K51/0408 ,  A61K51/08 ,  A61K51/088 ,  C07F9/10

摘要： Non-invasive method of monitoring by radioactivity bioscanning the distribution of a biological entity in a subject in vivo by administering to the subject a radioiodinated form of the biological entity. The radioiodinated form is prepared by contacting an aqueous suspension of the biological entity with a radioiodinated construct of the structure F-S-L where F comprises a radioiodinated tyrosine moiety, S is a spacer covalently linking F to L, and L is a lipid.

摘要翻译： 公开了结构F-S-L的功能 - 脂质构建体，其中F包含酪氨酸或组氨酸残基，S是共价连接F与L并且L是脂质的间隔基。 功能性残基可以被碘化并用于用1251放射性标记生物实体，碘化构建体用于监测生物体在体内分布的非侵入性方法。

公开(公告)号：EP2449386A1

公开(公告)日：2012-05-09

申请号：EP10794415.9

申请日：2010-06-29

申请人： Bovin, Nikolai Vladimirovich ,  Henry, Stephen Micheal ,  Parker, Stephen Robert

发明人： Bovin, Nikolai Vladimirovich ,  Henry, Stephen Micheal ,  Parker, Stephen Robert

IPC分类号： G01N33/80

CPC分类号： G01N33/5308 ,  G01N33/92

摘要： Methods of manufacturing cards, strips and multiwell plates for use in diagnostic assays are described. The methods employ the use of synthetic constructs of the generic structure F-S-L (where F is an antigen for a reactive antibody, S is a spacer covalently linking F to L, and L is a lipid) as “ink” in inkjet printers. The cards, strips and multiwell plates provide a number of advantages including efficiency of manufacture and improved accuracy in determining and recording assay results.

公开(公告)号：EP3226924A4

公开(公告)日：2018-08-01

申请号：EP15856243

申请日：2015-11-03

申请人： BOVIN NICOLAI VLADIMIROVICH ,  HENRY STEPHEN MICHEAL ,  RODIONOV IGOR LEONIDOVICH

IPC分类号： A01N57/12 ,  A01N25/04 ,  A01P1/00 ,  A61L15/46 ,  A61L27/04 ,  A61L27/50 ,  A61L27/54 ,  A61L31/02 ,  A61L31/14 ,  A61L31/16

CPC分类号： A01N57/12 ,  A61L15/46 ,  A61L27/042 ,  A61L27/50 ,  A61L27/54 ,  A61L31/022 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/22 ,  A61L2300/404 ,  A01N25/04

摘要： An antimicrobial surface treatment method comprising the step of contacting a stainless-steel surface with an aqueous dispersion of at least one functional-lipid construct where the lipid moiety is a phosphatidylethanolamine and the functional moiety confers the antimicrobial activity.