专利检索 ap:("Bacher, Adelbert" OR "Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin") AND inv:"HUBER, Robert" 第 1 页

1.

发明公开
CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE 有权
标题翻译： 2-C-甲基-D-赤藓醇2,4-环二合酶的晶体结构

公开(公告)号：EP1390488A2

公开(公告)日：2004-02-25

申请号：EP02748701.6

申请日：2002-05-13

申请人： Bacher, Adelbert , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin

发明人： BACHER, Adelbert , HECHT, Stefan , HUBER, Robert , KAISER, Johannes , ROHDICH, Felix , STEINBACHER, Stefan

IPC分类号： C12N9/88 , G06F17/50 , G06F19/00

CPC分类号： C12Y406/01012 , C07K2299/00 , C12N9/88

摘要： This invention discloses the crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and crystal structures of said synthase with 4-diphosphocytidyl-2C-methyl-D-erythritol, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate, cytidine monophosphate, cytidine diphosphate, cytidine and a combination of cytidine monophosphate and 2C-methyl-D-erythritol 2,4-cyclodiphosphate; with or without zinc. Further, computer-aided methods of identifying inhibitors of said synthase and inhibitors are provided.

2.

发明授权
CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE 有权
标题翻译： 2-C-甲基-D-赤藓醇2,4-环二合酶的晶体结构

公开(公告)号：EP1390488B1

公开(公告)日：2007-08-29

申请号：EP02748701.6

申请日：2002-05-13

申请人： Bacher, Adelbert , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： BACHER, Adelbert , HECHT, Stefan , HUBER, Robert , KAISER, Johannes , ROHDICH, Felix , STEINBACHER, Stefan

IPC分类号： C12N9/88 , G06F17/50 , G06F19/00

CPC分类号： C12Y406/01012 , C07K2299/00 , C12N9/88

摘要： This invention discloses the crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and crystal structures of said synthase with 4-diphosphocytidyl-2C-methyl-D-erythritol, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate, cytidine monophosphate, cytidine diphosphate, cytidine and a combination of cytidine monophosphate and 2C-methyl-D-erythritol 2,4-cyclodiphosphate; with or without zinc. Further, computer-aided methods of identifying inhibitors of said synthase and inhibitors are provided.