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公开(公告)号：EP2964748A1
公开(公告)日：2016-01-13
申请号：EP14760094.4
申请日：2014-03-06
申请人： Calysta, Inc.
CPC分类号： C12P5/007 , C07C11/10 , C12N9/0006 , C12N9/0093 , C12N9/1022 , C12N9/1205 , C12N9/1241 , C12N9/88 , C12N15/52 , C12Y101/01267 , C12Y117/01002 , C12Y117/07001 , C12Y207/01148 , C12Y207/0706 , C12Y402/03027 , C12Y406/01012 , Y02E50/343
摘要： The present disclosure provides compositions and methods for biologically producing isoprene using methanotrophic bacteria that utilize carbon feedstock, such as methane or natural gas.
摘要翻译： 本公开提供了使用利用碳原料例如甲烷或天然气的甲烷营养细菌生物生产异戊二烯的组合物和方法。
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公开(公告)号：EP2855662A1
公开(公告)日：2015-04-08
申请号：EP13797982.9
申请日：2013-06-04
发明人： CHEN, Wendy , LIEW, FungMin , KOEPKE, Michael
CPC分类号： C12P5/007 , C12N15/52 , C12N15/74 , C12P7/42 , C12P9/00 , C12Y101/01088 , C12Y101/01267 , C12Y117/07001 , C12Y202/01007 , C12Y203/01009 , C12Y203/0301 , C12Y205/0101 , C12Y205/0109 , C12Y207/01036 , C12Y207/01148 , C12Y207/04002 , C12Y207/0706 , C12Y401/01033 , C12Y402/03027 , C12Y402/03046 , C12Y406/01012 , C12Y503/03002 , Y02E50/343
摘要： The invention provides a method for producing a terpene or a precursor thereof by microbial fermentation. Typically, the method involves culturing a recombinant bacterium in the presence of a gaseous substrate whereby the bacterium produces a terpene or a precursor thereof, such as mevalonic acid, isopentenyl pyrophosphate, dimethylallyl pyrophosphate, isoprene, geranyl pyrophosphate, farnesyl pyrophosphate, and/or farnesene. The bacterium may comprise one or more exogenous enzymes, such as enzymes in mevalonate, DXS, or terpene biosynthesis pathways.
摘要翻译： 萜烯是用于各种行业的有价值的商业产品。 萜烯可由石化来源和萜烯原料如松节油生产。 然而，这些生产方法价格昂贵，不可持续，往往造成环境问题，包括造成气候变化。 微生物发酵为生产萜烯提供了另一种选择。 一种或多种萜烯和/或前体可以通过包含CO的底物的微生物发酵来生产。重组微生物可以用于这种方法中。 嗜羧基，产乙酸，重组微生物可用于此类方法。 例如，重组微生物可含有外源甲羟戊酸（MVA）途径酶和/或DXS途径酶。
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3.发明公开
公开(公告)号：EP2855662A4
公开(公告)日：2015-12-30
申请号：EP13797982
申请日：2013-06-04
发明人： CHEN WENDY , LIEW FUNGMIN , KOEPKE MICHAEL
CPC分类号： C12P5/007 , C12N15/52 , C12N15/74 , C12P7/42 , C12P9/00 , C12Y101/01088 , C12Y101/01267 , C12Y117/07001 , C12Y202/01007 , C12Y203/01009 , C12Y203/0301 , C12Y205/0101 , C12Y205/0109 , C12Y207/01036 , C12Y207/01148 , C12Y207/04002 , C12Y207/0706 , C12Y401/01033 , C12Y402/03027 , C12Y402/03046 , C12Y406/01012 , C12Y503/03002 , Y02E50/343
摘要： The invention provides a method for producing a terpene or a precursor thereof by microbial fermentation. Typically, the method involves culturing a recombinant bacterium in the presence of a gaseous substrate whereby the bacterium produces a terpene or a precursor thereof, such as mevalonic acid, isopentenyl pyrophosphate, dimethylallyl pyrophosphate, isoprene, geranyl pyrophosphate, farnesyl pyrophosphate, and/or farnesene. The bacterium may comprise one or more exogenous enzymes, such as enzymes in mevalonate, DXS, or terpene biosynthesis pathways.
摘要翻译： 萜烯是用于不同行业的有价值的商业产品。 萜烯可以由石化源和萜烯原料如松节油生产。 然而，这些生产方法是昂贵的，不可持续的，并且经常引起包括气候变化的环境问题。 微生物发酵为萜烯的生产提供了替代选择。 一种或多种萜烯和/或前体可以通过包含CO的底物的微生物发酵产生。重组微生物可以用于这些方法中。 在这些方法中可以使用羧基营养型，乙酰酵素，重组微生物。 例如，重组微量元件可以含有外源甲羟戊酸（MVA）途径酶和/或DXS途径酶。
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4.发明授权CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE 有权2-C-甲基-D-赤藓醇2,4-环二合酶的晶体结构
公开(公告)号：EP1390488B1
公开(公告)日：2007-08-29
申请号：EP02748701.6
申请日：2002-05-13
发明人： BACHER, Adelbert , HECHT, Stefan , HUBER, Robert , KAISER, Johannes , ROHDICH, Felix , STEINBACHER, Stefan
CPC分类号： C12Y406/01012 , C07K2299/00 , C12N9/88
摘要： This invention discloses the crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and crystal structures of said synthase with 4-diphosphocytidyl-2C-methyl-D-erythritol, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate, cytidine monophosphate, cytidine diphosphate, cytidine and a combination of cytidine monophosphate and 2C-methyl-D-erythritol 2,4-cyclodiphosphate; with or without zinc. Further, computer-aided methods of identifying inhibitors of said synthase and inhibitors are provided.
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公开(公告)号：EP2855662B1
公开(公告)日：2018-03-21
申请号：EP13797982.9
申请日：2013-06-04
发明人： CHEN, Wendy , LIEW, FungMin , KOEPKE, Michael
CPC分类号： C12P5/007 , C12N15/52 , C12N15/74 , C12P7/42 , C12P9/00 , C12Y101/01088 , C12Y101/01267 , C12Y117/07001 , C12Y202/01007 , C12Y203/01009 , C12Y203/0301 , C12Y205/0101 , C12Y205/0109 , C12Y207/01036 , C12Y207/01148 , C12Y207/04002 , C12Y207/0706 , C12Y401/01033 , C12Y402/03027 , C12Y402/03046 , C12Y406/01012 , C12Y503/03002 , Y02E50/343
摘要： The invention provides a method for producing a terpene or a precursor thereof by microbial fermentation. Typically, the method involves culturing a recombinant bacterium in the presence of a gaseous substrate whereby the bacterium produces a terpene or a precursor thereof, such as mevalonic acid, isopentenyl pyrophosphate, dimethylallyl pyrophosphate, isoprene, geranyl pyrophosphate, farnesyl pyrophosphate, and/or farnesene. The bacterium may comprise one or more exogenous enzymes, such as enzymes in mevalonate, DXS, or terpene biosynthesis pathways.
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公开(公告)号：EP2964748A4
公开(公告)日：2016-11-02
申请号：EP14760094
申请日：2014-03-06
申请人： CALYSTA INC
CPC分类号： C12P5/007 , C07C11/10 , C12N9/0006 , C12N9/0093 , C12N9/1022 , C12N9/1205 , C12N9/1241 , C12N9/88 , C12N15/52 , C12Y101/01267 , C12Y117/01002 , C12Y117/07001 , C12Y207/01148 , C12Y207/0706 , C12Y402/03027 , C12Y406/01012 , Y02E50/343
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7.发明公开CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE 有权2-C-甲基-D-赤藓醇2,4-环二合酶的晶体结构
公开(公告)号：EP1390488A2
公开(公告)日：2004-02-25
申请号：EP02748701.6
申请日：2002-05-13
发明人： BACHER, Adelbert , HECHT, Stefan , HUBER, Robert , KAISER, Johannes , ROHDICH, Felix , STEINBACHER, Stefan
CPC分类号： C12Y406/01012 , C07K2299/00 , C12N9/88
摘要： This invention discloses the crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and crystal structures of said synthase with 4-diphosphocytidyl-2C-methyl-D-erythritol, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate, cytidine monophosphate, cytidine diphosphate, cytidine and a combination of cytidine monophosphate and 2C-methyl-D-erythritol 2,4-cyclodiphosphate; with or without zinc. Further, computer-aided methods of identifying inhibitors of said synthase and inhibitors are provided.
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