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    ADJUVANTS FOR USE IN VACCINATION
    5.
    发明公开
    ADJUVANTS FOR USE IN VACCINATION 审中-公开
    ADJUVANSFÜRIMPFUNG

    公开(公告)号：EP2278996A1

    公开(公告)日：2011-02-02

    申请号：EP09736007.7

    申请日：2009-04-22

    申请人： Bangor University ,  Universiteit Gent

    发明人： BAIRD, Mark Stephen ,  AL-DULAYYMI, Juma' a Raheem Najeem ,  THEUNISSEN, Cornelias ,  KOZA, Gani ,  VANDER BEKEN, Seppe ,  GROOTEN, Johan Adriaan Marc

    IPC分类号： A61K39/04 ,  A61K39/39

    CPC分类号： A61K39/39 ,  A61K2039/55555

    摘要： A compound of formula (I) for use as an adjuvant in vaccination; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R
    1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R
    2 , R
    3 and R
    4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene or cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester, thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C-OR
    5 ; wherein R
    5 is alkyl or haloalkyl, and A is S, O or NR
    6 , wherein R
    6 maybe H or 20 alkyl.

    摘要翻译： 描述了用于疫苗接种中佐剂的式IId化合物; 其中R 6为氢或C 1至C 4烷基，R 7为氢或C 1至C 4烷基，p为16至30，q为8至24，r为12至28，s为12至28 。

    COMPOUNDS FOR USE IN THERAPY
    6.
    发明公开
    COMPOUNDS FOR USE IN THERAPY 审中-公开
    VERBINDUNGENFÜRTHERAPEUTISCHE ZWECKE

    公开(公告)号：EP2278995A2

    公开(公告)日：2011-02-02

    申请号：EP09735284.3

    申请日：2009-04-22

    申请人： Bangor University ,  Universiteit Gent

    发明人： BAIRD, Mark Stephen ,  AL-DULAYYMI, Juma' a Raheem Najeem ,  THEUNISSEN, Cornelias ,  KOZA, Gani ,  VANDER BEKEN, Seppe ,  GROOTEN, Johan Adriaan Marc

    IPC分类号： A61K39/04 ,  A61K39/39

    CPC分类号： A61K31/00 ,  A61K9/0073 ,  A61K9/127 ,  C07B2200/07 ,  C07C59/11 ,  C07C59/13 ,  C07C59/185 ,  C07C59/215 ,  C07C2601/02

    摘要： A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R
    1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R
    2 , R
    3 and R
    4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C-OR
    5 ; wherein R
    5 is alkyl or haloalkyl, and A is O, S or NR
    6 , wherein R
    6 may be H or 20 alkyl.

    摘要翻译： 用于治疗免疫系统疾病的式（I）化合物; 其中R是具有1至50个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R1是具有1至40个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R2，R3和R4各自独立地选自具有1至40个碳原子的任选取代的亚烷基，亚烯基，亚炔基，亚芳基，芳基亚烷基或烷基亚芳基; X，Y和Z各自独立地选自任选取代的亚烷基，亚烯基，亚烯基，亚芳基，亚烷基亚芳基，亚环烷基，酮，酯，酰胺，酰亚胺，亚胺，硫醚，醚，硫酯和硫酮; 并且P选自氢，烷基，糖残基或金属，鏻或铵物质; 其中X，Y和Z中的至少一个包括选自环丙基，C = A，C-AH和C-OR 5的部分; 其中R 5是烷基或卤代烷基，A是O，S或NR 6，其中R 6可以是H或20烷基。

    FRACTIONATION OF CASHEW NUT SHELL LIQUID
    7.
    发明公开
    FRACTIONATION OF CASHEW NUT SHELL LIQUID 审中-公开
    CASHEW坚果壳液的分级

    公开(公告)号：EP2566596A2

    公开(公告)日：2013-03-13

    申请号：EP11725951.5

    申请日：2011-05-04

    申请人： Bangor University

    发明人： DE BRAGANÇA, Radek Messias ,  BAIRD, Mark Stephen

    IPC分类号： B01D11/04 ,  C07C37/72

    CPC分类号： B01D11/0492 ,  C07C37/72 ,  C07C51/48 ,  C07C39/19 ,  C07C65/19

    摘要： A method for the fractionation of cashew nut shell liquid comprises solvent-solvent extraction using a polar solvent component and a non-polar, non-acidic, non-basic solvent component; wherein the polar solvent component is a mixture comprising: i) a first solvent comprising a fluorinated solvent; and ii) a second solvent comprising a solvent satisfying the following parameters: a) Hildebrand parameter greater than 10 (kcal dnT
    -3 )
    0,5 and b) dipolarity/polarizability (π), hydrogen bond acidity (a), and hydrogen bond basicity (β) having the following relationship: α/(α + β + π) > 0.5; β/(α + β + π) 0.3.

    摘要翻译： 用于分级腰果壳油的方法包括使用极性溶剂组分和非极性非酸性非碱性溶剂组分提取溶剂 - 溶剂; 其中所述极性溶剂组分是包含以下的混合物：i）包含氟化溶剂的第一溶剂; 和ii）包含满足以下参数的溶剂的第二溶剂：a）Hildebrand参数大于10（kcal dnT-3）0.5和b）偶极性/极化率（π），氢键酸度（a）和氢键 碱度（β）具有以下关系：α/（α+β+π）> 0.5; β/（α+β+π）<0.8; 和π/（α+β+π）> 0.3。

    METHOD FOR DETERMINING EXPOSURE TO MYCOBACTERIA
    9.
    发明公开
    METHOD FOR DETERMINING EXPOSURE TO MYCOBACTERIA 审中-公开
    VERFAHREN ZUR BESTIMMUNG DER EXPOSITIONGEGENÜBERMYKOBAKTERIEN

    公开(公告)号：EP2691773A1

    公开(公告)日：2014-02-05

    申请号：EP12718731.8

    申请日：2012-03-30

    申请人： Bangor University

    发明人： GWENIN, Christopher David ,  BAIRD, Mark Stephen

    IPC分类号： G01N33/569 ,  G01N33/58

    CPC分类号： G01N33/5695 ,  G01N33/582 ,  G01N2469/20

    摘要： A method of determining the presence or absence in a sample of a biomarker indicative of exposure to mycobacteria, the method comprising: (a) providing a substrate carrying a mycolic acid derived antigen; (b) contacting the substrate with the sample; (c) contacting the substrate with a fluorophore species; (d) creating an evanescent wave at the boundary of the substrate and the sample; (e) detecting the presence or absence of fluorescence.

    摘要翻译： 一种确定样品中存在或不存在指示暴露于分枝​​杆菌的生物标志物的方法，所述方法包括：（a）提供携带霉菌酸衍生抗原的底物; （b）使基材与样品接触; （c）使所述底物与荧光团物质接触; （d）在衬底和样品的边界处产生ev逝波; （e）检测是否存在荧光。