公开(公告)号：EP0411664A3

公开(公告)日：1991-07-24

申请号：EP90114980.7

申请日：1990-08-03

申请人： Banyu Pharmaceutical Co., Ltd.

发明人： Nakagawa, Susumu, Banyu Pharmaceutical Co., Ltd. ,  Nakano, Fumio, Banyu Pharmaceutical Co., Ltd. ,  Otake, Norikazu, Banyu Pharmaceutical Co., Ltd. ,  Ushijima, Ryosuke, Banyu Pharmaceutical Co., Ltd.

IPC分类号： C07D477/00 ,  A61K31/40

CPC分类号： C07D477/20 ,  Y02P20/55

摘要： A compound of the formula:
wherein R 1 is a hydrogen atom or a methyl group, R 2 is a hydrogen atom or a lower alkyl group, each of R 3 , R 4 and R 5 is a hydrogen atom or a lower alkyl group, or R 3 and R 4 together form a methylene group, an ethylene group or a propylene group, or R 4 and R 5 form together with the adjacent nitrogen atom an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a piperazinyl group or a morpholino group; or a pharmaceutically acceptable salt or ester thereof.

公开(公告)号：EP0411664B1

公开(公告)日：1995-01-18

申请号：EP90114980.7

申请日：1990-08-03

申请人： Banyu Pharmaceutical Co., Ltd.

发明人： Nakagawa, Susumu, Banyu Pharmaceutical Co., Ltd. ,  Nakano, Fumio, Banyu Pharmaceutical Co., Ltd. ,  Otake, Norikazu, Banyu Pharmaceutical Co., Ltd. ,  Ushijima, Ryosuke, Banyu Pharmaceutical Co., Ltd.

IPC分类号： C07D477/00 ,  A61K31/40

CPC分类号： C07D477/20 ,  Y02P20/55

公开(公告)号：EP0411664A2

公开(公告)日：1991-02-06

申请号：EP90114980.7

申请日：1990-08-03

申请人： Banyu Pharmaceutical Co., Ltd.

发明人： Nakagawa, Susumu, Banyu Pharmaceutical Co., Ltd. ,  Nakano, Fumio, Banyu Pharmaceutical Co., Ltd. ,  Otake, Norikazu, Banyu Pharmaceutical Co., Ltd. ,  Ushijima, Ryosuke, Banyu Pharmaceutical Co., Ltd.

IPC分类号： C07D477/00 ,  A61K31/40

CPC分类号： C07D477/20 ,  Y02P20/55

摘要： A compound of the formula:
wherein R 1 is a hydrogen atom or a methyl group, R 2 is a hydrogen atom or a lower alkyl group, each of R 3 , R 4 and R 5 is a hydrogen atom or a lower alkyl group, or R 3 and R 4 together form a methylene group, an ethylene group or a propylene group, or R 4 and R 5 form together with the adjacent nitrogen atom an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a piperazinyl group or a morpholino group; or a pharmaceutically acceptable salt or ester thereof.

摘要翻译： 下式的化合物，其中R 1是氢原子或甲基，R 2是氢原子或低级烷基，R 3，R 4和R 4中的每一个 5是氢原子或低级烷基，或者R 3和R 4一起形成亚甲基，亚乙基或亚丙基，或者R 4和R 5与 相邻氮原子，氮丙啶基，氮杂环丁烷基，吡咯烷基，哌啶子基，哌嗪基或吗啉代基; 或其药学上可接受的盐或酯。