专利检索 ap:("Baruch S. Blumberg Institute" OR "Drexel University") AND inv:"BLOCK, Timothy, M." 第 1 页

1.

发明公开
FUNCTIONALIZED BENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION 审中-公开
标题翻译：官能化的苯甲酰胺衍生物作为针对HBV感染的抗病毒剂

公开(公告)号：EP2928459A2

公开(公告)日：2015-10-14

申请号：EP13859675.4

申请日：2013-12-05

申请人： Baruch S. Blumberg Institute , Drexel University

发明人： XU, Xiaodong , BLOCK, Timothy, M. , GUO, Ju-Tao , DU, Yanming

IPC分类号： A61K31/165

CPC分类号： C07C233/66 , C07C233/75 , C07C235/64 , C07C2602/10 , C07D317/46 , C07D317/68 , C07D319/18 , C07D321/10 , C07D333/68 , C07D333/70 , C07D333/72 , C07D495/04

摘要： Pharmaceutical compositions of the invention comprise functionalized benzamide derivatives useful as pregenomic RNA encapsidation inhibitors, useful for the treatment of Hepatitis B virus (HBV) infection.

2.

发明公开
EARLY DETECTION OF HEPATOCELLULAR CARCINOMA 审中-公开

公开(公告)号：EP3419646A1

公开(公告)日：2019-01-02

申请号：EP17757011.6

申请日：2017-02-16

申请人： Drexel University

发明人： BLOCK, Timothy, M. , WANG, Mengjun , MEHTA, Anand

IPC分类号： A61K38/16 , C07K16/06 , G01N33/68 , G01N33/53 , G01N33/574

3.

发明公开
DIAGNOSIS OF LIVER PATHOLOGY THROUGH ASSESSMENT OF PROTEIN GLYCOSYLATION 审中-公开

公开(公告)号：EP3578985A1

公开(公告)日：2019-12-11

申请号：EP19186710.0

申请日：2006-05-05

申请人： Philadelphia Health and Education Corporation d/b/a Drexel University College of Medicine

发明人： BLOCK, Timothy, M. , METHA, Anand , COMUNALE, Mary, Ann

IPC分类号： G01N33/574 , G01N33/68

摘要： Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting glycosylation, and more specifically fucosylation, on proteins in biological fluids, and comparing the detected glycosylation with reference values for the glycosylation of such proteins in healthy or disease states.

4.

发明公开
SULFAMOYLBENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION 审中-公开
标题翻译：作为抗病毒药物抗乙型肝炎感染的磺胺苯甲酰胺衍生物

公开(公告)号：EP2726459A1

公开(公告)日：2014-05-07

申请号：EP12807810.2

申请日：2012-06-29

申请人： Institute for Hepatitis and Virus Research , Philadelphia Health and Education Corporation d/b/a Drexel University College of Medicine

发明人： GUO, Ju-Tao , XU, Xiaodong , BLOCK, Timothy, M.

IPC分类号： C07D211/06

CPC分类号： C07C311/46 , A61K31/167 , A61K31/18 , A61K31/341 , A61K31/44 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/553 , A61K2300/00 , C07D211/96 , C07D213/40 , C07D223/04 , C07D281/16 , C07D295/26 , C07D307/52 , C07D307/68

摘要： Pharmaceutical compositions of the invention comprise sulfamoylbenzamide derivative useful as pregenomic RNA encapsidation inhibitors, useful for the treatment of Hepatitis B virus (HBV) infection.

摘要翻译： 本发明的药物组合物包含用作前基因组RNA包衣抑制剂的氨磺酰基苯甲酰胺衍生物，其可用于治疗乙型肝炎病毒（HBV）感染。