专利检索 ap:("Basilea Pharmaceutica AG" OR "Universität Basel") AND inv:"MORONI, Christoph" 第 1 页

1.

发明公开
COMBINATION THERAPY FOR THE TREATMENT OF CANCER AND IMMUNOSUPPRESSION 审中-公开
标题翻译：联合疗法治疗癌症和免疫抑制

公开(公告)号：EP2872505A1

公开(公告)日：2015-05-20

申请号：EP13732982.7

申请日：2013-07-03

申请人： Basilea Pharmaceutica AG , Universität Basel

发明人： POHLMANN, Jens , BENJAMIN, Don Gary , MORONI, Christoph

IPC分类号： C07D459/00 , A61K31/475 , A61P35/00 , A61P37/06

CPC分类号： A61K31/475 , A61K31/155 , A61K31/365 , A61K45/06 , C07D459/00 , C07D471/14 , G01N33/5011 , G01N2458/00 , G01N2500/10

摘要： The invention relates to novel Rauwolfia alkaloid derivatives of formula (I) combinations of Rauwolfia alkaloid derivatives and a mitochondrial inhibitor, e.g. metformin, and the use of Rauwolfia alkaloid derivatives in combination with mitochondrial inhibitor for the treatment of cancer and for achieving clinical immunosuppression. The invention also relates to a fluorescence-based method for predicting the sensitivity of a cancer cell towards a compound of formula (I).

2.

发明公开
COMBINATION OF SYROSINGOPINE AND MITOCHONDRIAL INHIBITORS FOR THE TREATMENT OF CANCER AND IMMUNOSUPPRESSION 审中-公开
标题翻译： SYROSINGOPIN-和MITOCHONDRIALHEMMERN可用于治疗癌症和免疫抑制组合

公开(公告)号：EP2663298A1

公开(公告)日：2013-11-20

申请号：EP12700325.9

申请日：2012-01-09

申请人： Universität Basel

发明人： BENJAMIN, Don , COLOMBI, Marco , HALL, Michael , MORONI, Christoph

IPC分类号： A61K31/155 , A61K31/35 , A61K31/4745 , A61K31/625 , A61K31/7072

CPC分类号： A61K31/475 , A61K31/155 , A61K31/35 , A61K31/365 , A61K31/4375 , A61K31/4745 , A61K31/625 , A61K31/7072 , A61K45/06 , A61K2300/00

摘要： The invention relates to a combination of syrosingopine and a mitochondrial inhibitor, e.g. metformin or oligomycin, and the use of the combination of syrosingopine and a mitochondrial inhibitor for the treatment of cancer and for achieving immunosuppression. The invention also relates to a fluorescence-based method for predicting syrosingopine sensitivity of a cancer cell.