公开(公告)号：EP2968483A1

公开(公告)日：2016-01-20

申请号：EP14719469.0

申请日：2014-03-13

申请人： Baxalta Incorporated ,  Baxalta GmbH

发明人： SCHIVIZ, Alexandra, Nathalie ,  HOELLRIEGL, Werner ,  PLAIMAUER, Barbara ,  ROTTENSTEINER, Hanspeter ,  MUCHITSCH, Eva-Maria

IPC分类号： A61K38/48 ,  A61P7/02

CPC分类号： A61K38/4886 ,  A61K9/0019 ,  A61K9/19 ,  C12N9/6489 ,  C12Y304/24087

摘要： This invention relates to methods of subcutaneous administration of ADAMTS13 formulations to a treat a disease or condition associated with ADAMTS13 and VWF dysfunction. Furthermore, evidence of the unexpectedly high bioavailability of ADAMTS13 formulations administered subcutaneously is provided herein.

摘要翻译： 本发明涉及皮下给予ADAMTS13制剂以治疗与ADAMTS13和VWF功能障碍相关的疾病或病症的方法。 此外，本文提供了皮下给药的ADAMTS13制剂意想不到的高生物利用度的证据。

公开(公告)号：EP2350294B1

公开(公告)日：2018-12-05

申请号：EP09752581.0

申请日：2009-10-27

申请人： Baxalta GmbH ,  Baxalta Incorporated

发明人： SCHWARZ, Hans-Peter ,  MUCHITSCH, Eva-Maria ,  TURECEK, Peter

IPC分类号： C12N15/85 ,  A01K67/027 ,  A61K49/00

CPC分类号： A61K49/0008 ,  A01K67/027 ,  A01K67/0275 ,  A01K67/0276 ,  A01K2217/052 ,  A01K2217/054 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0306 ,  A01K2267/0325 ,  A01K2267/0381 ,  C12N15/8509

摘要： The invention relates to the development of an animal model for testing various agents in the treatment of a clotting disorder. More specifically, the invention relates to the use of ultra-large molecular weight multimers of von Willebrand factor (VWF) in various mouse strains to induce thrombotic thrombocytopenic purpura (TTP)-like symptoms for the development of a mouse model of TTP. The invention also provides methods for generating such animal disease models and screening methods for identifying biologically active compounds which are effective in the treatment of TTP.