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1.发明授权SOLID PHASE-BOUND ELASTASE-BINDING ASSAY FOR THE MEASUREMENT OF ALPHA-1-ANTITRYPSIN ACTIVITY 有权固相BOUND弹性蛋白酶结合测试测量α1-抗ANTITRYPSINAKTIVITÄT
公开(公告)号：EP2715349B1
公开(公告)日：2016-03-02
申请号：EP12720103.6
申请日：2012-04-25
申请人： Baxalta GmbH , Baxalta Incorporated
CPC分类号： G01N33/68 , G01N33/53 , G01N2333/8125 , G01N2333/966
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2.发明授权
公开(公告)号：EP2358895B1
公开(公告)日：2018-05-30
申请号：EP09764426.4
申请日：2009-12-03
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： VARADI, Katalin , ROTTENSTEINER, Hanspeter , TURECEK, Peter , SCHWARZ, Hans-Peter , SCHREINER, Jutta
IPC分类号： G01N33/573 , C12Q1/37 , C12Q1/56 , G01N33/86
CPC分类号： G01N33/86 , C12Q1/37 , C12Q1/56 , G01N33/573 , G01N2333/755 , G01N2333/96486 , G01N2800/224 , G01N2800/52
摘要： The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
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公开(公告)号：EP2352820B1
公开(公告)日：2017-04-26
申请号：EP09759839.5
申请日：2009-11-12
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： ZAYDENBERG, Alexander , WEBER, Susan , GAVIT, Patrick , LEI, Laura , TESCHNER, Wolfgang , BUTTERWECK, Harald , MAIS-PAUL, Ursula , SCHWARZ, Hans-Peter
IPC分类号： C12N9/18
CPC分类号： C12N9/18
摘要： The present invention relates to purification of butyrylcholinesterase using anion exchange material, where the butyrylcholinesterase content is enriched at least 10 fold per total protein in the composition.
摘要翻译： 本发明涉及使用阴离子交换材料纯化丁酰胆碱酯酶，其中丁酰胆碱酯酶含量在组合物中每个总蛋白富集至少10倍。
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4.发明授权STABILIZED LIQUID AND LYOPHILIZED ADAMTS13 FORMULATIONS 有权稳定器LYOPHILISIERTEFLÜSSIGEZUSAMMENSETZUNGEN VON ADAMTS13
公开(公告)号：EP2480198B9
公开(公告)日：2016-11-23
申请号：EP10759786.6
申请日：2010-09-21
申请人： Baxalta GmbH , Baxalta Incorporated
CPC分类号： A61K38/4886 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/26 , C12Y304/24087
摘要： The present invention relates to formulations of ADAMTS13 with enhanced or desirable properties. As such, the invention provides liquid and lyophilized formulations of ADAMTS13 that are suitable for pharmaceutical administration. Among other aspects, the present invention also provides methods of treating various diseases and conditions related to VWF and/or ADAMTS13 dysfunction in a subject. Also provided herein are kits comprising ADAMTS13 formulations useful for the treatment of various diseases and conditions.
摘要翻译： 本发明涉及具有增强或期望性质的ADAMTS13制剂。 因此，本发明提供适用于药物给药的ADAMTS13的液体和冻干制剂。 除了其它方面，本发明还提供了治疗受试者中与VWF和/或ADAMTS13功能障碍相关的各种疾病和病症的方法。 本文还提供了包含可用于治疗各种疾病和病症的ADAMTS13制剂的试剂盒。
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公开(公告)号：EP2968455A2
公开(公告)日：2016-01-20
申请号：EP14718870.0
申请日：2014-03-14
申请人： Baxalta Incorporated , Baxalta GmbH , Madlener, Ruth , Schwarz, Hans-Peter , Svatos, Sonja , Teschner, Wolfgang , Pljevljakovic, Azra , Nitsch, Lena
发明人： MADLENER, Ruth , SCHWARZ, Hans-Peter , SVATOS, Sonja , TESCHNER, Wolfgang , PLJEVLJAKOVIC, Azra , NITSCH, Lena
CPC分类号： C07K14/47 , A61K35/16 , A61K38/1725
摘要： The present disclosure provides, among other aspects, improved methods for the manufacture of Factor H compositions from plasma precipitation fractions. In some aspects, the methods include an improved process step for extracting Factor H from a plasma precipitate fraction with reduced co-extraction of amidolytic activities. In other aspects, the methods include a heat treatment step for reducing impurities, such as amidolytic enzymes, from a Factor H composition. In yet other aspects, the methods include improved anion exchange, heparin affinity, and/or mixed mode chromatographic enrichment of Factor H. In still other aspects, the improved methods include a combination of the individual improved process steps disclosed herein.
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公开(公告)号：EP2994160B1
公开(公告)日：2019-07-03
申请号：EP14730660.9
申请日：2014-05-05
申请人： Baxalta Incorporated , Baxalta GmbH
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7.发明公开
公开(公告)号：EP3388529A8
公开(公告)日：2018-12-26
申请号：EP18173838.6
申请日：2009-12-03
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： VARADI, Katalin , ROTTENSTEINER, Hanspeter , TURECEK, Peter , SCHWARZ, Hans-Peter , SCHREINER, Jutta
CPC分类号： G01N33/86 , C12Q1/37 , C12Q1/56 , G01N33/573 , G01N2333/755 , G01N2333/96486 , G01N2800/224 , G01N2800/52
摘要： The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
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公开(公告)号：EP2632479B1
公开(公告)日：2017-06-14
申请号：EP11796846.1
申请日：2011-10-27
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： STEINITZ, Katharina, Nora , WILHELMINA VAN HELDEN, Paula, Maria , REIPERT, Birgit, Maria , SCHWARZ, Hans-Peter , EHRLICH, Hartmut
IPC分类号： A61K38/37 , C07K14/755 , A61P7/04
CPC分类号： C07K14/755 , A61K38/37 , C07K2319/00 , C12P21/00 , G01N33/505 , G01N33/56977
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9.发明授权METHODS FOR DIFFERENTIATING PLASMA-DERIVED PROTEIN FROM RECOMBINANT PROTEIN IN A SAMPLE 有权方法分化的蛋白质从血浆中的重组蛋白在样本
公开(公告)号：EP2223108B1
公开(公告)日：2016-04-06
申请号：EP08868946.8
申请日：2008-12-22
申请人： Baxalta GmbH , Baxalta Incorporated
IPC分类号： G01N33/68
CPC分类号： G01N33/6842 , G01N2333/4724 , G01N2333/755 , Y10S436/827 , Y10T436/10 , Y10T436/105831 , Y10T436/106664
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10.发明授权STABLE CO-FORMULATION OF HYALURONIDASE AND IMMUNOGLOBULIN, AND METHODS OF USE THEREOF 有权稳定共表达透明质酸酶及免疫球蛋白的制造方法及其使用
公开(公告)号：EP2477603B1
公开(公告)日：2016-03-30
申请号：EP10760140.3
申请日：2010-09-16
申请人： Baxalta Incorporated , Baxalta GmbH
发明人： TESCHNER, Wolfgang , SVATOS, Sonja , BRUCKSCHWAIGER, Leopold , WEBER, Alfred , SCHWARZ, Hans-Peter , LEI, Laura
IPC分类号： A61K9/00 , A61K47/36 , A61K47/42 , A61K39/00 , A61K39/395 , C07K16/00 , C07K16/06 , C12N9/24
CPC分类号： A61K39/00 , A61K9/0021 , A61K39/39591 , A61K47/42 , A61K2039/505 , C07K16/00 , C07K16/06 , C07K2317/21 , C12N9/2474 , C12Y302/01035 , Y02A50/464
摘要： Provided herein are stable co-formulations of immunoglobulin and hyaluronidase that are stable to storage in liquid form at room temperature for at least 6 months and at standard refrigerator temperatures for 1-2 years. Such co-formulations can be used in methods of treating IG-treatable diseases or conditions by subcutaneous administration.
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