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    GLYCOPOLYSIALYLATION OF PROTEINS OTHER THAN BLOOD COAGULATION PROTEINS
    1.
    发明公开
    GLYCOPOLYSIALYLATION OF PROTEINS OTHER THAN BLOOD COAGULATION PROTEINS 审中-公开
    葡萄糖ON ON ON ON EN EN EN EN EN EN EN EN EN EN EN EN

    公开(公告)号：EP3081233A1

    公开(公告)日：2016-10-19

    申请号：EP16168473.3

    申请日：2010-07-26

    申请人： Baxalta GmbH ,  Baxalta Incorporated ,  Lipoxen Technologies Limited

    发明人： Jain, Sanjay ,  Gregoriadis, Gregory ,  Dwivedi, Archana ,  Nath, Srijit ,  Siekmann, Juergen ,  Haider, Stefan ,  Rottensteiner, Hanspeter ,  Turecek, Peter

    IPC分类号： A61K47/48

    CPC分类号： A61K47/6455 ,  A61K47/60 ,  A61K47/61 ,  A61K47/65

    摘要： A water soluble polymer, in particular polysialic acid (PSA) or a modified PSA (mPSA), is conjugated to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein or to a ganglioside or drug delivery system by contacting the oxidized carbohydrate moiety with the water soluble polymer, wherein said water soluble polymer contains an aminooxy group and an oxime linkage is formed between the oxidized carbohydrate moiety and the aminooxy group on the water soluble polymer or wherein said water soluble polymer contains a hydrazide group and a hydrazone linkage is formed between the oxidized carbohydrate moiety and the hydrazide group on the water soluble polymer. Conjugates of aminooxy- or hydrazide-water soluble polymer, such as PSA and mPSA, are thus obtained in which the PSA or mPSA is attached via a carbohydrate moiety.

    摘要翻译： 将水溶性聚合物，特别是聚唾液酸（PSA）或修饰的PSA（mPSA）与不同于凝血蛋白的糖蛋白的氧化碳水化合物部分缀合或通过使氧化的碳水化合物部分接触而与神经节苷脂或药物递送系统 其中所述水溶性聚合物含有氨基氧基，并且在水溶性聚合物上的氧化碳水化合物部分和氨基氧基之间形成肟键，或者其中所述水溶性聚合物含有酰肼基，腙键是 形成在水溶性聚合物上的氧化碳水化合物部分和酰肼基团之间。 因此得到氨基氧基或酰肼 - 水溶性聚合物如PSA和mPSA的结合物，其中PSA或mPSA通过碳水化合物部分连接。

    Reduction of endotoxin in polysialic acids
    6.
    发明公开
    Reduction of endotoxin in polysialic acids 审中-公开
    减少聚唾液酸中的内毒素

    公开(公告)号：EP2409995A3

    公开(公告)日：2012-08-15

    申请号：EP11185324.8

    申请日：2008-02-28

    申请人： Lipoxen Technologies Limited

    发明人： Jain, Sanjay ,  Laing, Peter ,  Gregoriadis, Gregory

    IPC分类号： C08B37/00

    CPC分类号： C08B37/0006 ,  B01D15/363 ,  C08B37/0003

    摘要： The endotoxin content of a sample containing polysaccharide e.g. PSA and endotoxin is reduced by passing the sample through an affinity chromatography column to which endotoxin adsorbs, whereby polysaccharide passes through the column and is collected to provide a product solution of polysaccharide e.g. PSA having reduced endotoxin content. A multistep process can be used and columns used comprise a polymixin B gel, Detoxi-Gel, Cellufine, EndoTrap Red or EndoTrap Blue.

    摘要翻译： 含有多糖例如 通过使样品通过内毒素吸附的亲和色谱柱来减少PSA和内毒素，由此使多糖通过色谱柱并收集以提供多糖的产物溶液，例如， 内毒素含量降低的PSA。 可以使用多步法并且使用的柱包含多粘菌素B凝胶，Detoxi-Gel，Cellufine，EndoTrap Red或EndoTrap Blue。

    Reduction of endotoxin in polysialic acids
    7.
    发明公开
    Reduction of endotoxin in polysialic acids 审中-公开
    呕吐von内毒素ausPolysialinsäuren

    公开(公告)号：EP2409995A2

    公开(公告)日：2012-01-25

    申请号：EP11185324.8

    申请日：2008-02-28

    申请人： Lipoxen Technologies Limited

    发明人： Jain, Sanjay ,  Laing, Peter ,  Gregoriadis, Gregory

    IPC分类号： C08B37/00

    CPC分类号： C08B37/0006 ,  B01D15/363 ,  C08B37/0003

    摘要： The endotoxin content of a sample containing polysaccharide e.g. PSA and endotoxin is reduced by passing the sample through an affinity chromatography column to which endotoxin adsorbs, whereby polysaccharide passes through the column and is collected to provide a product solution of polysaccharide e.g. PSA having reduced endotoxin content. A multistep process can be used and columns used comprise a polymixin B gel, Detoxi-Gel, Cellufine, EndoTrap Red or EndoTrap Blue.

    摘要翻译： 含有多糖的样品的内毒素含量 通过使样品通过吸附有内毒素的亲和色谱柱来降低PSA和内毒素，由此多糖通过柱并被收集以提供多糖的产物溶液，例如， PSA具有降低的内毒素含量。 可以使用多步骤方法，使用的柱包含多聚胶B凝胶，Detoxi-Gel，Cellufine，EndoTrap Red或EndoTrap Blue。

    Reduction of endotoxin in polysialic acids
    8.
    发明公开
    Reduction of endotoxin in polysialic acids 审中-公开
    呕吐von内毒素ausPolysialinsäuren

    公开(公告)号：EP2409994A2

    公开(公告)日：2012-01-25

    申请号：EP11185321.4

    申请日：2008-02-28

    申请人： Lipoxen Technologies Limited

    发明人： Jain, Sanjay ,  Laing, Peter ,  Gregoriadis, Gregory

    IPC分类号： C08B37/00

    CPC分类号： C08B37/0006 ,  B01D15/363 ,  C08B37/0003

    摘要： The endotoxin content of a sample containing polysaccharide e.g. PSA is reduced by passing the sample through a hydrophobic interaction column to which endotoxin adsorbs, whereby polysaccharide e.g. PSA passes through the column and is collected to provide a product solution of polysaccharide having reduced endotoxin content. Phenyl, butyl and octyl columns are for example used.

    摘要翻译： 含有多糖的样品的内毒素含量 通过使样品通过内毒素吸附的疏水相互作用柱来减少PSA，由此多糖例如 PSA通过柱并被收集以提供具有降低的内毒素含量的多糖的产物溶液。 例如使用苯基，丁基和辛基。