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公开(公告)号：EP2710375A1
公开(公告)日：2014-03-26
申请号：EP12725954.7
申请日：2012-05-18
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/6842 , G01N33/6857 , G01N2440/00
摘要： Disclosed herein are methods, systems and kits to measure the presence and/or activity of recombinant polypeptides comprising a modification.
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2.发明公开SOLID PHASE-BOUND ELASTASE-BINDING ASSAY FOR THE MEASUREMENT OF ALPHA1-ANTITRYPSIN ACTIVITY 有权固相BOUND弹性蛋白酶结合测试测量α1-抗ANTITRYPSINAKTIVITÄT
公开(公告)号：EP2715349A1
公开(公告)日：2014-04-09
申请号：EP12720103.6
申请日：2012-04-25
CPC分类号： G01N33/68 , G01N33/53 , G01N2333/8125 , G01N2333/966
摘要： The present invention relates to a method for the measurement of active alpha
1 -proteinase inhibitor (A1PI) in a sample, comprising the steps of binding elastase to a solid support, letting the A1PI contained in the sample bind to the solid phase-bound elastase, and detecting solid phase-bound A1PI with a detection reagent.-
3.发明公开REMOVAL OF SERINE PROTEASES BY TREATMENT WITH FINELY DIVIDED SILICON DIOXIDE 有权丝氨酸蛋白酶的距离。通过与二氧化硅细粉处理
公开(公告)号：EP2575762A2
公开(公告)日：2013-04-10
申请号：EP11729200.3
申请日：2011-05-26
发明人： TESCHNER, Wolfgang , SCHWARZ, Hans-Peter , MADLENER, Ruth , SVATOS, Sonja , PLJEVLJAKOVIC, Azra , WEBER, Alfred
CPC分类号： C07K1/36 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K47/183 , C07K1/14 , C07K1/18 , C07K1/30 , C07K1/34 , C07K16/065
摘要： The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.
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4.发明公开STABLE CO-FORMULATION OF HYALURONIDASE AND IMMUNOGLOBULIN, AND METHODS OF USE THEREOF 有权稳定共表达透明质酸酶及免疫球蛋白的制造方法及其使用
公开(公告)号：EP2477603A2
公开(公告)日：2012-07-25
申请号：EP10760140.3
申请日：2010-09-16
发明人： TESCHNER, Wolfgang , SVATOS, Sonja , BRUCKSCHWAIGER, Leopold , WEBER, Alfred , SCHWARZ, Hans-Peter , LEI, Laura
IPC分类号： A61K9/00 , A61K47/36 , A61K47/42 , A61K39/00 , A61K39/395 , C07K16/00 , C07K16/06 , C12N9/24
CPC分类号： A61K39/00 , A61K9/0021 , A61K39/39591 , A61K47/42 , A61K2039/505 , C07K16/00 , C07K16/06 , C07K2317/21 , C12N9/2474 , C12Y302/01035 , Y02A50/464
摘要： Provided herein are stable co-formulations of immunoglobulin and hyaluronidase that are stable to storage in liquid form at room temperature for at least 6 months and at standard refrigerator temperatures for 1-2 years. Such co-formulations can be used in methods of treating IG-treatable diseases or conditions by subcutaneous administration.
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5.发明授权REMOVAL OF SERINE PROTEASES BY TREATMENT WITH FINELY DIVIDED SILICON DIOXIDE 有权丝氨酸蛋白酶的距离。通过与二氧化硅细粉处理
公开(公告)号：EP2575762B1
公开(公告)日：2014-07-09
申请号：EP11729200.3
申请日：2011-05-26
发明人： TESCHNER, Wolfgang , SCHWARZ, Hans-Peter , MADLENER, Ruth , SVATOS, Sonja , PLJEVLJAKOVIC, Azra , WEBER, Alfred
CPC分类号： C07K1/36 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K47/183 , C07K1/14 , C07K1/18 , C07K1/30 , C07K1/34 , C07K16/065
摘要： The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.
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6.发明授权DETECTION OF PHYSIOLOGICALLY ACCEPTABLE POLYMER MOLECULES USING NEAR INFRARED SPECTROSCOPY 有权PROOF生理安全聚合物分子使用近红外光谱仪
公开(公告)号：EP2356467B1
公开(公告)日：2013-07-10
申请号：EP09768592.9
申请日：2009-12-11
IPC分类号： G01N33/86 , G01N33/68 , G01N21/00 , G01N33/487
CPC分类号： G01N33/6842 , G01N21/359 , G01N33/86 , G01N2333/745 , G01N2333/755 , G01N2333/76 , Y10T436/203332
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7.发明公开MEASUREMENT OF AUTOANTIBODIES AT LOW CONDUCTIVITY CONDITIONS WITH INCREASED SENSITIVITY 有权自身抗体测量低电导率使用更高的灵敏度
公开(公告)号：EP2791675A1
公开(公告)日：2014-10-22
申请号：EP12820994.7
申请日：2012-12-13
IPC分类号： G01N33/53 , G01N33/564 , A61K39/395 , G01N33/543
CPC分类号： G01N33/6854 , G01N33/54393 , G01N33/564 , G01N2333/4709
摘要： Methods for detecting or capturing low-avidity autoantibodies in a biological sample are provided. Target antigen used to assay for the low-avidity autoantibodies of interest is immobilized on a solid phase. The biological sample is contacted under low conductivity condition with the target antigen for which the autoantibodies has specific binding affinity. Binding of the target antigen to the autoantibodies of interest in the biological sample is then detected to ascertain the presence or concentration of the autoantibodies of interest.
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8.发明授权METHOD AND COMPOSITIONS FOR SPECIFICALLY DETECTING PHYSIOLOGICALLY ACCEPTABLE POLYMER MOLECULES 有权方法和组合物特异性检测生理安全的聚合物分子
公开(公告)号：EP2245456B1
公开(公告)日：2013-02-13
申请号：EP08866117.8
申请日：2008-12-23
发明人： TURECEK, Peter , SIEKMANN, Juergen , WEBER, Alfred , GRITSCH, Herbert , VARADI, Katalin , VEJDA, Susanne
CPC分类号： G01N33/86 , G01N33/5308 , G01N2430/60
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9.发明公开DETECTION OF PHYSIOLOGICALLY ACCEPTABLE POLYMER MOLECULES USING NEAR INFRARED SPECTROSCOPY 有权PROOF生理安全聚合物分子使用近红外光谱仪
公开(公告)号：EP2356467A1
公开(公告)日：2011-08-17
申请号：EP09768592.9
申请日：2009-12-11
IPC分类号： G01N33/86 , G01N33/68 , G01N21/00 , G01N33/487
CPC分类号： G01N33/6842 , G01N21/359 , G01N33/86 , G01N2333/745 , G01N2333/755 , G01N2333/76 , Y10T436/203332
摘要： The present invention relates, in general, to methods for detecting the amount of a polymer on a protein using near-infrared spectroscopy. Measurement of the number of polymer moieties per protein molecule allows for production of molecules having a uniform number of polymer moieties, which is useful in the production of pharmaceutical compositions.
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10.发明公开METHOD AND COMPOSITIONS FOR SPECIFICALLY DETECTING PHYSIOLOGICALLY ACCEPTABLE POLYMER MOLECULES 有权方法和组合物特异性检测生理安全的聚合物分子
公开(公告)号：EP2245456A2
公开(公告)日：2010-11-03
申请号：EP08866117.8
申请日：2008-12-23
发明人： TURECEK, Peter , SIEKMANN, Juergen , WEBER, Alfred , GRITSCH, Herbert , VARADI, Katalin , VEJDA, Susanne
IPC分类号： G01N33/53
CPC分类号： G01N33/86 , G01N33/5308 , G01N2430/60
摘要： The present invention relates to a method for determining the amount of a physiologically acceptable polymer molecule bound to a protein, an antibody or other composition being capable of specifically binding to a physiologically acceptable polymer molecule, and a kit containing said antibody or composition.
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