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1.发明公开FVIII PEPTIDES FOR IMMUNE TOLERANCE INDUCTION AND IMMUNODIAGNOSTICS 有权FVIII-PEPTIDE ZUR IMMUNTOLERANZINDUKTION UND IMMUNDIAGNOSTIK
公开(公告)号：EP2632479A1
公开(公告)日：2013-09-04
申请号：EP11796846.1
申请日：2011-10-27
发明人： STEINITZ, Katharina, Nora , WILHELMINA VAN HELDEN, Paula, Maria , REIPERT, Birgit, Maria , SCHWARZ, Hans-Peter , EHRLICH, Hartmut
IPC分类号： A61K38/37 , C07K14/755 , A61P7/04
CPC分类号： C07K14/755 , A61K38/37 , C07K2319/00 , C12P21/00 , G01N33/505 , G01N33/56977
摘要： The present invention is related to peptides that can be used to reduce the immune response against FVIII or to induce tolerance to human FVIII in patients with, e.g., hemophilia A. Furthermore, the peptides can be used for immunodiagnostic purposes to detect FVIII- specific CD4
+ T cells to monitor patients with hemophilia A during replacement therapy and during immune tolerance induction therapy.摘要翻译： 本发明涉及可用于减少针对FVIII的免疫应答或诱导对例如血友病A的患者对人FVIII的耐受性的肽。此外，该肽可用于免疫诊断目的以检测FVIII-特异性CD4 + T细胞在替代治疗期间和免疫耐受诱导治疗期间监测血友病A患者。
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2.发明公开METHODS FOR THE INACTIVATION OF MICROORGANISMS IN BIOLOGICAL FLUIDS, FLOW THROUGH REACTORS AND METHODS OF CONTROLLING THE LIGHT SUM DOSE TO EFFECTIVELY INACTIVATE MICROORGANISMS IN BATCH REACTORS 审中-公开微生物的生物体液灭活方法; 流经电抗器和方法，用于控制光总剂量在间歇反应器中微生物的有效灭活
公开(公告)号：EP1784229A2
公开(公告)日：2007-05-16
申请号：EP05770162.5
申请日：2005-08-04
发明人： ANDERLE, Heinz , MATTHIESSEN, Peter , SCHWARZ, Hans-Peter , TURECEK, Peter , KREIL, Thomas , BOGGS, Daniel, R.
CPC分类号： A61L2/10 , A23L3/26 , A23L3/28 , A61L2/0011 , A61L2/28 , G01N21/33 , H05B3/0052
摘要： The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivete microorganisms present in a biological fluid, preferably a non-trannsparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.
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3.发明公开A method to produce a highly concentrated immunoglobulin preparation for subcutaneous use 审中-公开一种生产用于皮下使用高度浓缩的免疫球蛋白制剂过程
公开(公告)号：EP2762492A2
公开(公告)日：2014-08-06
申请号：EP14162703.4
申请日：2010-05-27
发明人： TESCHNER, Wolfgang , BUTTERWECK, Harald Arno , PLJEVLJAKOVIC, Azra , BAUER, Theresa Friederike , KOELBL, Bernhard , SCHWARZ, Hans-Peter , NIKOLIC, Nebojsa , POELSLER, Gerhard , KINDERMANN, Johanna
IPC分类号： C07K16/06
CPC分类号： C07K16/18 , A61K39/39591 , A61K2039/505 , A61K2039/54 , B01D61/142 , B01D61/145 , B01D2315/16 , C07K16/00 , C07K16/065 , C07K2317/10 , C07K2317/21
摘要： The present invention relates to a new and improved method for preparing a highly concentrated immunoglobulin composition from pooled plasma for subcutaneous injection. A composition comprising 20% or more immunoglobulin suitable for subcutaneous use is also described.
摘要翻译： 本发明涉及一种用于从用于皮下注射混合血浆制备高度浓缩的免疫球蛋白组合物的新的改进方法。 由此描述了包含20％或适用于皮下使用多种免疫球蛋白的组合物。
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4.发明公开STABILIZATION OF IMMUNOGLOBULINS THROUGH AQUEOUS FORMULATION WITH HISTIDINE AT WEAK ACIDIC TO NEUTRAL PH 审中-公开稳定价格在弱酸基于的水性制剂，免疫球蛋白组氨酸pH至中性
公开(公告)号：EP2616090A1
公开(公告)日：2013-07-24
申请号：EP11764040.9
申请日：2011-09-16
发明人： BUTTERWECK, Harald, Arno , KÖLBL, Bernhard , HOFBAUER, Lucia , TESCHNER, Wolfgang , SCHWARZ, Hans-Peter
CPC分类号： A61K39/39591 , A61K9/0019 , A61K47/02 , A61K47/183
摘要： The present invention provides, among other aspects, storage stabile aqueous formulations of labile proteins at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing a labile therapeutic protein composition at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of labile proteins at mildly acidic to neutral pH useful for parenteral administration.
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5.发明公开REMOVAL OF SERINE PROTEASES BY TREATMENT WITH FINELY DIVIDED SILICON DIOXIDE 有权丝氨酸蛋白酶的距离。通过与二氧化硅细粉处理
公开(公告)号：EP2575762A2
公开(公告)日：2013-04-10
申请号：EP11729200.3
申请日：2011-05-26
发明人： TESCHNER, Wolfgang , SCHWARZ, Hans-Peter , MADLENER, Ruth , SVATOS, Sonja , PLJEVLJAKOVIC, Azra , WEBER, Alfred
CPC分类号： C07K1/36 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K47/183 , C07K1/14 , C07K1/18 , C07K1/30 , C07K1/34 , C07K16/065
摘要： The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.
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6.发明公开STABLE CO-FORMULATION OF HYALURONIDASE AND IMMUNOGLOBULIN, AND METHODS OF USE THEREOF 有权稳定共表达透明质酸酶及免疫球蛋白的制造方法及其使用
公开(公告)号：EP2477603A2
公开(公告)日：2012-07-25
申请号：EP10760140.3
申请日：2010-09-16
发明人： TESCHNER, Wolfgang , SVATOS, Sonja , BRUCKSCHWAIGER, Leopold , WEBER, Alfred , SCHWARZ, Hans-Peter , LEI, Laura
IPC分类号： A61K9/00 , A61K47/36 , A61K47/42 , A61K39/00 , A61K39/395 , C07K16/00 , C07K16/06 , C12N9/24
CPC分类号： A61K39/00 , A61K9/0021 , A61K39/39591 , A61K47/42 , A61K2039/505 , C07K16/00 , C07K16/06 , C07K2317/21 , C12N9/2474 , C12Y302/01035 , Y02A50/464
摘要： Provided herein are stable co-formulations of immunoglobulin and hyaluronidase that are stable to storage in liquid form at room temperature for at least 6 months and at standard refrigerator temperatures for 1-2 years. Such co-formulations can be used in methods of treating IG-treatable diseases or conditions by subcutaneous administration.
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7.发明公开RECOMBINANT VON WILLIBRAND FACTOR AS A MOLECULAR WEIGHT MARKER FOR MASS SPECTROMETRY ANALYSES 有权重组血管性血友病因子分子量标准进行质量分析
公开(公告)号：EP2374004A1
公开(公告)日：2011-10-12
申请号：EP09771643.5
申请日：2009-12-16
发明人： KEMPTNER, Jasmin , MARCHETTI-DESCHMANN, Martina , MUELLER, Roland , IVENS, Andreas , TURECEK, Peter , SCHWARZ, Hans-Peter , ALLMAIER, Guenter
CPC分类号： G01N33/6851 , G01N2333/755 , H01J49/164
摘要： Methods for determining molecular mass of at least 150 kDa of an analyte of interest using MALDI mass spectrometry in combination with a recombinant von Willebrand factor (rVWF) molecular weight marker are disclosed. More specifically, monomeric and multimeric rVWF are used for external and internal calibration of mass spectra applied for analytes having high molecular weights above 150 kDa.
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8.发明公开METHODS OF DETERMINING POLYDISPERSITY AND/OR MOLECULAR WEIGHT DISTRIBUTION OF A POLYETHYLENE GLYCOL SAMPLE 审中-公开法确定多分散性和/或聚乙二醇探头的分子量分布
公开(公告)号：EP2366105A1
公开(公告)日：2011-09-21
申请号：EP09760672.7
申请日：2009-11-18
发明人： KEMPTNER, Jasmin , MARCHETTI-DESCHMANN, Martina , SIEKMANN, Juergen , TURECEK, Peter , SCHWARZ, Hans-Peter , ALLMAIER, Guenter
IPC分类号： G01N33/68
CPC分类号： G01N27/624
摘要： Disclosed herein are methods of determining polydispersity (PDI) and molecular mass distribution (MMD) of reactive PEG samples using mass spectrometry. More specifically, a mass spectrometry method called GEMMA is used to determine PDI and MMD of PEG samples which provides more accurate measurements for high molecular weight PEG samples than prior known MALDI-TOF analysis.
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9.发明公开METHODS OF MEASURING ADAMTS13-MEDIATED IN VIVO CLEAVAGE OF VON WILLEBRAND FACTOR AND USES THEREOF 有权值的测定方法ADAMTS13介导体内切割维勒布兰德因子及其用途
公开(公告)号：EP2358895A1
公开(公告)日：2011-08-24
申请号：EP09764426.4
申请日：2009-12-03
发明人： VARADI, Katalin , ROTTENSTEINER, Hanspeter , TURECEK, Peter , SCHWARZ, Hans-Peter , SCHREINER, Jutta
IPC分类号： C12Q1/37
CPC分类号： G01N33/86 , C12Q1/37 , C12Q1/56 , G01N33/573 , G01N2333/755 , G01N2333/96486 , G01N2800/224 , G01N2800/52
摘要： The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
摘要翻译： 本发明基因的反弹涉及测量裂解von Willebrand因子（VWF）的片段的方法。 更具体地，本发明涉及到测量整合素和金属蛋白酶的具有血小板反应类型1基序的，构件13（ADAMTS13）切割VWF体内的能力的方法。 因此，本发明涉及使用多种动物模型的方法演示了类似于做了人体的哪个ADAMTS13活性。 本发明还涉及到测量的r的vWF的切割产物在哺乳动物，特别是在人类和在人血浆中的方法。
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10.发明公开MODELS OF THROMBOTIC THROMBOCYTOPENIC PURPURA AND METHODS OF USE THEREOF 审中-公开VERFAHREN ZUR VEWENDUNG DAVON MODELLE TUVBOTISCH-THROMBOZYTOPENISCHE PURPURA
公开(公告)号：EP2350294A2
公开(公告)日：2011-08-03
申请号：EP09752581.0
申请日：2009-10-27
IPC分类号： C12N15/85 , A01K67/027 , A61K49/00
CPC分类号： A61K49/0008 , A01K67/027 , A01K67/0275 , A01K67/0276 , A01K2217/052 , A01K2217/054 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0325 , A01K2267/0381 , C12N15/8509
摘要： The invention relates to the development of an animal model for testing various agents in the treatment of a clotting disorder. More specifically, the invention relates to the use of ultra-large molecular weight multimers of von Willebrand factor (VWF) in various mouse strains to induce thrombotic thrombocytopenic purpura (TTP)-like symptoms for the development of a mouse model of TTP. The invention also provides methods for generating such animal disease models and screening methods for identifying biologically active compounds which are effective in the treatment of TTP.
摘要翻译： 本发明涉及用于测试治疗凝血障碍的各种药剂的动物模型的开发。 更具体地说，本发明涉及von Willebrand因子（VWF）的超大分子量多聚体在各种小鼠品系中的应用，以诱导血小板减少性紫癜（TTP）样症状，用于开发TTP小鼠模型。 本发明还提供了产生用于鉴定有效治疗TTP的生物活性化合物的这种动物疾病模型和筛选方法的方法。
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