公开(公告)号：EP1283989A2

公开(公告)日：2003-02-19

申请号：EP01945050.1

申请日：2001-04-26

申请人： Bayer Aktiengesellschaft ,  Bayer Corporation

发明人： VÖLKER, Michael ,  BECKA, Michael ,  KROLL, Werner ,  KNORR, Andreas ,  UNGER, Sylvia ,  GEHRMANN, Mathias ,  HENNIG, Guido ,  BURCHARDT, Elmar-Reinhold ,  ARTHUR, Michael, J. ,  BURT, Alastair, D. ,  PINZANI, Massimo ,  SCHUPPAN, Detlef

IPC分类号： G01N33/68 ,  G01N33/573

CPC分类号： G01N33/6893 ,  G01N33/6887 ,  G01N2333/47 ,  G01N2333/78 ,  G01N2333/8146 ,  G01N2333/96486 ,  G01N2800/085

摘要： The present invention concerns a method for diagnosing liver fibrosis wherein two or more diagnostic markers are measured and the measurements are correlated by a mathematic algorithm characterized in that the diagnostic markers are selected from the group N-terminal procollagen III propeptide (PIIINP), Collagen IV, Collagen VI, Tenascin, Laminin, Hyaluronan, MMP-2, TIMP-1 and MMP-9/TIMP-1 complex. The algorithm can be used to predict the histological score of a liver biopsy.

公开(公告)号：EP1283989B1

公开(公告)日：2007-07-11

申请号：EP01945050.1

申请日：2001-04-26

申请人： Bayer Aktiengesellschaft ,  BAYER CORPORATION

发明人： VÖLKER, Michael ,  BECKA, Michael ,  KROLL, Werner ,  KNORR, Andreas ,  UNGER, Sylvia ,  GEHRMANN, Mathias ,  HENNIG, Guido ,  BURCHARDT, Elmar-Reinhold ,  ARTHUR, Michael, J. ,  BURT, Alastair, D. ,  PINZANI, Massimo ,  SCHUPPAN, Detlef

IPC分类号： G01N33/68 ,  G01N33/573

CPC分类号： G01N33/6893 ,  G01N33/6887 ,  G01N2333/47 ,  G01N2333/78 ,  G01N2333/8146 ,  G01N2333/96486 ,  G01N2800/085

摘要： The present invention concerns a method for diagnosing liver fibrosis wherein two or more diagnostic markers are measured and the measurements are correlated by a mathematic algorithm characterized in that the diagnostic markers are selected from the group N-terminal procollagen III propeptide (PIIINP), Collagen IV, Collagen VI, Tenascin, Laminin, Hyaluronan, MMP-2, TIMP-1 and MMP-9/TIMP-1 complex. The algorithm can be used to predict the histological score of a liver biopsy.

公开(公告)号：EP1339403A2

公开(公告)日：2003-09-03

申请号：EP01989448.4

申请日：2001-11-09

申请人： Bayer Aktiengesellschaft

发明人： KROLL, Werner ,  ROMBOUT, Ferdinand ,  WEBER, Horst ,  RODRIGUEZ, Maria-Luisa ,  SENNHENN, Bernd ,  SCHOHE-LOOP, Rudolf

IPC分类号： A61K31/35 ,  A61K31/425 ,  G01N33/94

CPC分类号： C07D417/12 ,  G01N33/94

摘要： The invention relates to a kit comprising a pharmaceutical composition that contains repinotan or a physiologically acceptable salt of repinotan, and to a means for determining the concentration of repinotan or its metabolites in body fluids. The invention further relates to novel pharmaceutical compositions that contain repinotan or a physiologically acceptable salt of repinotan, and to a method for producing the same.

摘要翻译： 本发明涉及一种试剂盒，其包含含有肾上腺素或生理上可接受的肾上腺素盐的药物组合物，并涉及测定体液中肾上腺素或其代谢物浓度的方法。 本发明进一步涉及新颖的药物组合物及其生产方法，所述药物组合物含有瑞宁辛（repinotan）或生理上可接受的瑞宁诺坦盐。