公开(公告)号：EP1363912A1

公开(公告)日：2003-11-26

申请号：EP02704706.7

申请日：2002-02-11

申请人： Bayer Aktiengesellschaft

发明人： NIEWÖHNER, Ulrich ,  SCHAUSS, Dagmar ,  KÖNIG, Gerhard ,  HENDRIX, Martin ,  BÖSS, Frank-Gerhard ,  VAN DER STAAY, Franz-Josef ,  SCHREIBER, Rudy ,  SCHLEMMER, Karl-Heinz ,  MORIWAKI, Toshiya ,  NIEWÖHNER, Maria Theresia

IPC分类号： C07D487/04 ,  A61K31/53 ,  A61P25/00 ,  C07D253/06

CPC分类号： C07D253/07 ,  C07D487/04

摘要： The invention relates to novel substituted imidazotriazinones, to a method for their production and to the use thereof for producing medicaments, in particular to improve perception, powers of concentration, learning capacity and/or memory retentiveness.

摘要翻译： 本发明涉及新型取代的咪唑并三嗪酮，其制备方法及其用于制备药物的用途，特别是改善知觉，注意力，学习能力和/或记忆保持力的能力。

公开(公告)号：EP1117651A1

公开(公告)日：2001-07-25

申请号：EP99969935.8

申请日：1999-09-29

申请人： Bayer Aktiengesellschaft

发明人： MITTENDORF, Joachim ,  HENNING, Rolf ,  RADDATZ, Siegfried ,  SCHLEMMER, Karl-Heinz ,  HIRAOKA, Makiko ,  KADONO, Hiroshi ,  MOGI, Muneto ,  MORIWAKI, Toshiya ,  MURATA, Toshiki ,  SAKAKIBARA, Sachiko ,  SHIMADA, Mitsuyuki ,  YOSHIDA, Nagahiro ,  YOSHINO, Takashi

IPC分类号： C07D235/20 ,  C07D403/14 ,  C07D401/14 ,  C07D471/04 ,  A61K31/4184 ,  A61K31/437

CPC分类号： C07D401/14 ,  C07D235/20 ,  C07D403/14 ,  C07D471/04

摘要： Bis-benzimidazole compounds of general formula (I) in which R?1, R2, R3 and R4¿ are hydrogen, hydroxy or halogen, R?5 and R8¿ are hydrogen, or (C¿1?-C4)-alkyl,R?6 and R7¿ are hydrogen, or (C¿1?-C6)-alkyl, hydroxy, halogen, or (C1-C6)-alkoxy, R?9, R10 and R11¿ are hydrogen, halogen, nitro, cyano or trifluoromethyl, and A is a non-aromatic 5-7-membered N-heterocycle, etc, process for their preparation and their use for treating diseases associated with tryptase activity including allergic, inflammatory and related immunological diseases, in particular asthma, allergic rhinitis, allergic conjunctivitis and allergic dermatitis.

公开(公告)号：EP1242394A1

公开(公告)日：2002-09-25

申请号：EP00983231.2

申请日：2000-12-06

申请人： Bayer Aktiengesellschaft

发明人： MORIWAKI, Toshiya ,  FÜRSTNER, Chantal ,  RIEDL, Bernd ,  ERGÜDEN, Jens-Kerim ,  BÖSS, Frank-Gerhard ,  SCHMIDT, Bernard ,  VAN DER STAAY, Franz-Josef ,  SCHRÖDER, Werner ,  SCHLEMMER, Karl-Heinz ,  YOSHIDA, Nagahiro

IPC分类号： C07D261/20 ,  A61K31/423 ,  A61P25/28 ,  A61P25/04

CPC分类号： C07D261/20

摘要： The invention relates to novel 3-oxo-2,1-benzisoxazol-1(3H)-carboxamides (I), where R1, R2 are the same or different and independently = H, halogen, C¿1? C6 alkyl, C1 C6 alkoxy, C1 C3 perfluoroalkyl, or a group NR?5R6; R3, R4¿ are the same or different and independently = C¿1? C8 alkyl, whose carbon chain is optionally interrupted by an O, S or NR?7¿ and is optionally singly or severally substituted by C¿3? C6 cycloalkyl, C1 C4 alkoxy, OH, halogen or NR?8R9; C¿3 C8 cycloalkyl whose carbon chain is optionally interrupted by an O, S or NR10 and is optionally singly or severally substituted by C¿1? C4 alkoxy, OH, halogen or NR?11R12; or R3 and R4¿ together with a nitrogen atom form a saturated or partially unsaturated 3- to 10-membered mono- or bi-cyclic heterocycle, which, optionally, contains up to two further heteroatoms, from N, O or S and is, optionally, substituted by C¿1? C4 alkyl, C1 C4 alkoxy, OH, halogen, COOR?13 or NR14R15¿and X = O or S. The invention further relates to methods for production thereof and use thereof in the production of medicaments for the prophylaxis and/or treatment of diseases of the central nervous system, in particular, cognitive disorders, such as Alzheimer's disease and other forms of dementia, cerebral infarct, skull and brain trauma and pain.