公开(公告)号：EP1535076A2

公开(公告)日：2005-06-01

申请号：EP03792291.1

申请日：2003-08-11

申请人： Bayer HealthCare AG

发明人： YALKINOGLU, Özkan ,  KÖNIG, Gerhard ,  HOCHSTRASSER, Denis, Francois ,  SANCHEZ, Jean-Charles ,  CARRETTE, Odile

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  C07K14/70539 ,  C07K14/805 ,  C07K14/8139 ,  G01N2800/2821

摘要： A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies detection of specific markers in body fluids (e.g. CSF), using mass spectrometric analysis (SELDI-TOF MS). The specific markers are: human cystatin C, human beta-2-microglobulin, human myoglobin neurosecretory protein VGF or fragments of these proteins.

公开(公告)号：EP1535076B1

公开(公告)日：2008-08-06

申请号：EP03792291.1

申请日：2003-08-11

申请人： Bayer HealthCare AG

发明人： YALKINOGLU, Özkan ,  KÖNIG, Gerhard ,  HOCHSTRASSER, Denis, Francois ,  SANCHEZ, Jean-Charles ,  CARRETTE, Odile

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  C07K14/70539 ,  C07K14/805 ,  C07K14/8139 ,  G01N2800/2821

摘要： A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies detection of specific peptide markers, e.g., using mass spectrometric analysis.