公开(公告)号：EP1521756A1

公开(公告)日：2005-04-13

申请号：EP03738083.9

申请日：2003-06-25

申请人： Bayer HealthCare AG

发明人： HENDRIX, Martin ,  BRÜCKNER, David ,  FRIEDL, Arno ,  GERLACH, Irene ,  HINZ, Volker ,  KELDENICH, Jörg ,  MAULER, Frank ,  SCHAUSS, Dagmar ,  SCHLEMMER, Karl-Heinz ,  TERSTEEGEN, Adrian ,  YALKINOGLU, Özkan ,  NIEWÖHNER, Ulrich DI

IPC分类号： C07D487/04 ,  A61K31/53 ,  A61P25/16 ,  A61P25/18

CPC分类号： C07D487/04 ,  A61K31/53

摘要： The invention relates to novel hetero-cyclically substituted imidazotriazines and a method for the production and use thereof for producing drugs which are used for curing and/or preventing cancers and neurodegenerative diseases, in particular Parkinson disease and schizophrenia.

公开(公告)号：EP1535076A2

公开(公告)日：2005-06-01

申请号：EP03792291.1

申请日：2003-08-11

申请人： Bayer HealthCare AG

发明人： YALKINOGLU, Özkan ,  KÖNIG, Gerhard ,  HOCHSTRASSER, Denis, Francois ,  SANCHEZ, Jean-Charles ,  CARRETTE, Odile

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  C07K14/70539 ,  C07K14/805 ,  C07K14/8139 ,  G01N2800/2821

摘要： A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies detection of specific markers in body fluids (e.g. CSF), using mass spectrometric analysis (SELDI-TOF MS). The specific markers are: human cystatin C, human beta-2-microglobulin, human myoglobin neurosecretory protein VGF or fragments of these proteins.

公开(公告)号：EP1535076B1

公开(公告)日：2008-08-06

申请号：EP03792291.1

申请日：2003-08-11

申请人： Bayer HealthCare AG

发明人： YALKINOGLU, Özkan ,  KÖNIG, Gerhard ,  HOCHSTRASSER, Denis, Francois ,  SANCHEZ, Jean-Charles ,  CARRETTE, Odile

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  C07K14/70539 ,  C07K14/805 ,  C07K14/8139 ,  G01N2800/2821

摘要： A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies detection of specific peptide markers, e.g., using mass spectrometric analysis.

公开(公告)号：EP1599479A1

公开(公告)日：2005-11-30

申请号：EP03735677.1

申请日：2003-06-25

申请人： Bayer HealthCare AG

发明人： HENDRIX, Martin ,  BRÜCKNER, David ,  FRIEDL, Arno ,  GERLACH, Irene ,  HINZ, Volker ,  KELDENICH, Jörg ,  MAULER, Frank ,  NIEWÖHNER, Ulrich ,  KARTHAUS, Dagmar ,  SCHLEMMER, Karl-Heinz ,  TERSTEEGEN, Adrian ,  YALKINOGLU, Özkan

IPC分类号： C07D487/04 ,  A61K31/53

CPC分类号： C07D487/04 ,  A61K31/53

摘要： The invention relates to novel substituted imidazotriazines, to methods for the production thereof, and to their use for producing medicaments for the treatment and/or prophylaxis of cancer and neurodegenerative diseases, particularly Parkinson's disease and schizophrenia.

摘要翻译： 本发明涉及新型取代的咪唑并三嗪，其制备方法及其用于制备用于治疗和/或预防癌症和神经退行性疾病，特别是帕金森病和精神分裂症的药物的用途。