Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 1 (DPP1)
    2.
    发明公开
    Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 1 (DPP1) 审中-公开
    诊断和治疗二肽基肽酶1(DPP1)辅助Krankheiten

    公开(公告)号:EP2017620A2

    公开(公告)日:2009-01-21

    申请号:EP08017858.5

    申请日:2005-04-15

    IPC分类号: G01N33/573

    摘要: The invention provides a human DPP1 which is associated with the infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastro-enterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastro-enterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DPP1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译: 本发明提供了与癌症相关的人DPP1。 本发明还提供了用于鉴定可用于治疗或预防癌症的化合物的测定法。 本发明还涉及结合和/或活化或抑制DPP1的活性的化合物以及包含这些化合物的药物组合物。