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1.发明授权
公开(公告)号：EP2303910B1
公开(公告)日：2016-04-06
申请号：EP09793747.8
申请日：2009-07-06
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1019 , C07K14/811 , C12Q1/37 , G01N2333/96438 , G01N2500/04
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2.发明公开ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURIN AND PROPROTEIN CONVERTASE 5A (PC5A) 审中-公开经修饰的N-钙粘蛋白处理。在肿瘤细胞与弗林蛋白酶前蛋白转化酶5A（PC5A）
公开(公告)号：EP2211897A4
公开(公告)日：2011-04-13
申请号：EP08843796
申请日：2008-11-03
发明人： MARET DEBORAH , COLMAN DAVID R , GRUZGLIN EUGENIA , SEIDAH NABIL
IPC分类号： A61K38/43 , A61K31/7105 , A61K49/00 , A61P35/00 , G01N33/53
CPC分类号： A61K38/482 , A61K31/7105 , C12N15/1137 , C12N2310/14 , C12Y304/21075 , C12Y304/21826 , G01N33/57492 , G01N2333/705 , G01N2333/96438
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3.发明公开Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 1 (DPP1) 审中-公开诊断和治疗二肽基肽酶1（DPP1）辅助Krankheiten
公开(公告)号：EP2017620A2
公开(公告)日：2009-01-21
申请号：EP08017858.5
申请日：2005-04-15
申请人： Bayer HealthCare AG
IPC分类号： G01N33/573
CPC分类号： C12Q1/37 , G01N33/573 , G01N33/574 , G01N2333/96438 , G01N2500/04
摘要： The invention provides a human DPP1 which is associated with the infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastro-enterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastro-enterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DPP1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译： 本发明提供了与癌症相关的人DPP1。 本发明还提供了用于鉴定可用于治疗或预防癌症的化合物的测定法。 本发明还涉及结合和/或活化或抑制DPP1的活性的化合物以及包含这些化合物的药物组合物。
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4.发明公开MULTI-LEU PEPTIDES AND ANALOGUES THEREOF AS SELECTIVE PACE4 INHIBITORS AND EFFECTIVE ANTIPROLIFERATIVE AGENTS 有权MULTI-LEU肽及其类似物，其作为选择性抑制剂，和有效PACE4抗增殖剂
公开(公告)号：EP2303910A4
公开(公告)日：2012-08-01
申请号：EP09793747
申请日：2009-07-06
发明人： DAY ROBERT , FUGERE MARTIN , NEUGEBAUER WITOLD A
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1019 , C07K14/811 , C12Q1/37 , G01N2333/96438 , G01N2500/04
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5.发明公开ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURIN AND PROPROTEIN CONVERTASE 5A (PC5A) 审中-公开经修饰的N-钙粘蛋白处理。在肿瘤细胞与弗林蛋白酶前蛋白转化酶5A（PC5A）
公开(公告)号：EP2211897A1
公开(公告)日：2010-08-04
申请号：EP08843796.7
申请日：2008-11-03
申请人： The Royal Institution for the Advancement of Learning/McGill University , IRCM (Institut De Recherches Cliniques De Montreal) , Mount Sinai School Of Medicine
IPC分类号： A61K38/43 , A61K31/7105 , A61K49/00 , A61P35/00 , G01N33/53
CPC分类号： A61K38/482 , A61K31/7105 , C12N15/1137 , C12N2310/14 , C12Y304/21075 , C12Y304/21826 , G01N33/57492 , G01N2333/705 , G01N2333/96438
摘要： The present invention relates to a method for diagnosis and/or prognosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a subject by determining the molecular form of cadherin at the cell surface of cancer cells in the subject. The invention also relates to a method for preventing, inhibiting or treating cancer or its metastasis in a subject by increasing the adhesive forms of cadherin and/or decreasing the non-adhesive forms of cadherin at the cell surface. The invention also relates to a method step of determining the expression level of furin and proprotein convertase 5A (PC5A).
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6.发明公开MULTI-LEU PEPTIDES AND ANALOGUES THEREOF AS SELECTIVE PACE4 INHIBITORS AND EFFECTIVE ANTIPROLIFERATIVE AGENTS 有权选择性PACE4-IHBIBITOREN和它们在癌症治疗
公开(公告)号：EP2303910A1
公开(公告)日：2011-04-06
申请号：EP09793747.8
申请日：2009-07-06
IPC分类号： C07K5/11 , A61K38/07 , A61K38/08 , A61P35/00 , C07K5/10 , C07K7/06 , C12Q1/02 , G01N33/53 , G01N33/68 , C07K14/81 , C12N9/64
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1019 , C07K14/811 , C12Q1/37 , G01N2333/96438 , G01N2500/04
摘要： Disclosed herein are PACE4 inhibitors, compositions comprising PACE4 inhibitors and their uses thereof for lowering PACE4 activity, reducing cell proliferation, reducing tumor growth, reducing metastasis formation, preventing and/or treating cancer. Also provided are methods for lowering PACE4 activity, reducing the proliferation of a cell, reducing tumor growth and/or treating and preventing cancer. Methods for screening PACE4 inhibitors and cell proliferation inhibitors are further provided.
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7.发明公开Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 1 (DPP1) 审中-公开诊断和治疗与二肽基肽1（DPP1）相关的疾病
公开(公告)号：EP2017620A3
公开(公告)日：2009-04-22
申请号：EP08017858.5
申请日：2005-04-15
申请人： Bayer HealthCare AG
IPC分类号： G01N33/573
CPC分类号： C12Q1/37 , G01N33/573 , G01N33/574 , G01N2333/96438 , G01N2500/04
摘要： The invention provides a human DPP1 which is associated with cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of DPP1 as well as pharmaceutical compositions comprising such compounds.
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8.发明公开METHODS AND COMPOSITIONS FOR PROSTATE EPITHELIAL CELL DIFFERENTIATION 审中-公开方法和组合物由于F R DIEEPITHELZELLDIFFERENZIERUNG在前列腺
公开(公告)号：EP1575512A4
公开(公告)日：2007-08-29
申请号：EP03786610
申请日：2003-11-07
发明人： HRUSKA KEITH A , CHAUDHARY LALA R
CPC分类号： G01N33/57434 , A61K38/18 , G01N2333/52 , G01N2333/96438
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9.发明公开DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH DIPEPTIDYL-PEPTIDASE 1 (DPP1) 审中-公开DIAGNOSITKA与治疗与二肽基肽1（DPP1）相关的疾病
公开(公告)号：EP1745292A2
公开(公告)日：2007-01-24
申请号：EP05729922.4
申请日：2005-04-15
申请人： Bayer HealthCare AG
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： G01N33/573
CPC分类号： C12Q1/37 , G01N33/573 , G01N33/574 , G01N2333/96438 , G01N2500/04
摘要： The invention provides a human DPP1 which is associated with the infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DPP1 as well as pharmaceutical compositions comprising such compounds.
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10.发明公开METHODS AND COMPOSITIONS FOR PROSTATE EPITHELIAL CELL DIFFERENTIATION 审中-公开方法和组合物DIEEPITHELZELLDIFFERENZIERUNG在前列腺
公开(公告)号：EP1575512A2
公开(公告)日：2005-09-21
申请号：EP03786610.0
申请日：2003-11-07
IPC分类号： A61K6/00
CPC分类号： G01N33/57434 , A61K38/18 , G01N2333/52 , G01N2333/96438
摘要： Methods and compositions for treating prostate cancer by promoting prostate epithelial cell differentiation are described. Treatment methods involve administration of an active form of prostate-derived factor (PDF), or of an inactive PDF precursor, or of a combination of a proprotein convertase (PC) with a PDF precursor, to increase the biological activity of PDF in the subject and promote prostate epithelial cell differentiation.
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