公开(公告)号：EP0934311B1

公开(公告)日：2009-05-13

申请号：EP97912102.7

申请日：1997-10-02

申请人： Bayer HealthCare AG

发明人： STRAUB, Alexander ,  FÜRSTNER, Chantal ,  NIEWÖHNER, Ulrich ,  JAETSCH, Thomas ,  FEURER, Achim ,  KAST, Raimund ,  STASCH, Johannes-Peter ,  PERZBORN, Elisabeth ,  HÜTTER, Joachim ,  DEMBOWSKY, Klaus ,  ARLT, Dieter

IPC分类号： C07D405/04

CPC分类号： C07D401/04 ,  C07D263/32 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04

摘要： Disclosed are new heterocyclylmethyl-substituted pyrazol derivates, the preparation thereof and their use as drug products, particularly for treating cardiovascular diseases.

公开(公告)号：EP0932403B1

公开(公告)日：2005-11-30

申请号：EP97913132.3

申请日：1997-10-01

申请人： Bayer HealthCare AG

发明人： FÜRSTNER, Chantal ,  STRAUB, Alexander ,  NIEWÖHNER, Ulrich ,  JAETSCH, Thomas ,  FEURER, Achim ,  KAST, Raimund ,  STASCH, Johannes-Peter ,  PERZBORN, Elisabeth ,  HÜTTER, Joachim ,  DEMBOWSKY, Klaus

IPC分类号： A61K31/415 ,  C07D405/04 ,  C07D409/04 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P43/00

CPC分类号： C07D405/04 ,  A61K31/416

摘要： The present invention relates to the new application of condensated (hetaryl-substituted) 1-benzal-3-pyrazol derivates of general formula (I), where R1 to R4 have the meanings given in the description, as drug products and new active substances, and more particularly to their use as vasodilators, possibly combined with organic nitrates and NO donors, possibly combined with compounds which inhibit the degradation of cGMP.

公开(公告)号：EP0944631B1

公开(公告)日：2004-02-18

申请号：EP97951204.3

申请日：1997-11-14

申请人： Bayer HealthCare AG

发明人： STRAUB, Alexander ,  ROBYR, Chantal ,  JAETSCH, Thomas ,  FEURER, Achim ,  KAST, Raimund ,  STASCH, Johannes-Peter ,  PERZBORN, Elisabeth ,  HÜTTER, Joachim ,  DEMBOWSKY, Klaus

IPC分类号： C07D487/04 ,  C07D471/04 ,  A61K31/435 ,  A61K31/495 ,  A61K31/415

CPC分类号： C07D471/04 ,  C07D487/04