公开(公告)号：EP1751153A1

公开(公告)日：2007-02-14

申请号：EP05740054.1

申请日：2005-03-30

申请人： Bayer HealthCare AG

发明人： SCHIROK, Hartmut ,  RADTKE, Martin ,  MITTENDORF, Joachim ,  KAST, Raimund ,  STASCH, Johannes-Peter ,  GNOTH, Mark, Jean ,  MÜNTER, Klaus ,  LANG, Dieter ,  FIGUEROA, PEREZ, Santiago ,  THUTEWOHL, Michael ,  BENNABI, Samir ,  EHMKE, Heimo

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P9/00

CPC分类号： C07D471/04

摘要： The invention relates to hetaryloxy-substituted phenylamino pyrimidines, a method for the production thereof, and the use thereof for producing medicaments utilized for the treatment and/or prevention of diseases in humans and animals, particularly cardiovascular diseases.

公开(公告)号：EP0934311B1

公开(公告)日：2009-05-13

申请号：EP97912102.7

申请日：1997-10-02

申请人： Bayer HealthCare AG

发明人： STRAUB, Alexander ,  FÜRSTNER, Chantal ,  NIEWÖHNER, Ulrich ,  JAETSCH, Thomas ,  FEURER, Achim ,  KAST, Raimund ,  STASCH, Johannes-Peter ,  PERZBORN, Elisabeth ,  HÜTTER, Joachim ,  DEMBOWSKY, Klaus ,  ARLT, Dieter

IPC分类号： C07D405/04

CPC分类号： C07D401/04 ,  C07D263/32 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04

摘要： Disclosed are new heterocyclylmethyl-substituted pyrazol derivates, the preparation thereof and their use as drug products, particularly for treating cardiovascular diseases.

公开(公告)号：EP1966218A1

公开(公告)日：2008-09-10

申请号：EP06840964.8

申请日：2006-12-08

申请人： Bayer HealthCare AG

发明人： LAMPE, Thomas ,  BECKER, Eva-Maria ,  KAST, Raimund ,  BECK, Hartmut ,  JESKE, Mario ,  SCHUHMACHER, Joachim ,  STOLL, Friederike ,  KLEIN, Martina ,  AKBABA, Metin ,  KNORR, Andreas ,  STASCH, Johannes-Peter ,  BÄRFACKER, Lars ,  HILLISCH, Alexander ,  KARIG, Gunter ,  MEININGHAUS, Mark ,  SCHLEMMER, Karl-Heinz ,  SCHOHE-LOOP, Rudolf

IPC分类号： C07D491/04 ,  A61K31/519 ,  A61P9/00

CPC分类号： C07D491/04

摘要： The invention relates to novel, cyclic substituted furopyrimidine derivatives represented by formula (I), to methods for the production thereof, to the use thereof for treating and/or for the prophylaxis of illnesses and to the use thereof for producing medicaments for treating and/or for the prophylaxis of diseases, in particular for treating and/or for the prophylaxis of cardiovascular diseases.

公开(公告)号：EP1966217A1

公开(公告)日：2008-09-10

申请号：EP06829427.1

申请日：2006-12-08

申请人： Bayer HealthCare AG

发明人： LAMPE, Thomas ,  BECKER, Eva-Maria ,  KAST, Raimund ,  BECK, Hartmut ,  JESKE, Mario ,  SCHUHMACHER, Joachim ,  STOLL, Friederike ,  KLEIN, Martina ,  AKBABA, Metin ,  KNORR, Andreas ,  STASCH, Johannes-Peter ,  BÄRFACKER, Lars ,  HILLISCH, Alexander ,  KARIG, Gunter ,  MEININGHAUS, Mark ,  SCHLEMMER, Karl-Heinz ,  SCHOHE-LOOP, Rudolf

IPC分类号： C07D491/04 ,  A61K31/519 ,  A61P9/00

CPC分类号： C07D491/04

摘要： The invention relates to novel, acyclic substituted furopyrimidine derivatives represented by formula (I), to methods for the production thereof, to the use thereof for treating and/or for the prophylaxis of illnesses and to the use thereof for producing medicaments for treating and/or for the prophylaxis of diseases, in particular for treating and/or for the prophylaxis of cardiovascular diseases.

公开(公告)号：EP0932403B1

公开(公告)日：2005-11-30

申请号：EP97913132.3

申请日：1997-10-01

申请人： Bayer HealthCare AG

发明人： FÜRSTNER, Chantal ,  STRAUB, Alexander ,  NIEWÖHNER, Ulrich ,  JAETSCH, Thomas ,  FEURER, Achim ,  KAST, Raimund ,  STASCH, Johannes-Peter ,  PERZBORN, Elisabeth ,  HÜTTER, Joachim ,  DEMBOWSKY, Klaus

IPC分类号： A61K31/415 ,  C07D405/04 ,  C07D409/04 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P43/00

CPC分类号： C07D405/04 ,  A61K31/416

摘要： The present invention relates to the new application of condensated (hetaryl-substituted) 1-benzal-3-pyrazol derivates of general formula (I), where R1 to R4 have the meanings given in the description, as drug products and new active substances, and more particularly to their use as vasodilators, possibly combined with organic nitrates and NO donors, possibly combined with compounds which inhibit the degradation of cGMP.

公开(公告)号：EP1476164B1

公开(公告)日：2005-11-02

申请号：EP03737277.8

申请日：2003-01-27

申请人： Bayer HealthCare AG

发明人： ERGÜDEN, Jens-Kerim ,  KOLKHOF, Peter ,  CASTRO-PALOMINO, Julio ,  KUHL, Alexander ,  KAST, Raimund ,  STASCH, Johannes-Peter ,  TINEL, Hanna ,  MÜNTER, Klaus ,  LUSTIG, Klemens ,  PERNERSTORFER, Josef ,  BECHEM, Martin ,  HÜSER, Jörg

IPC分类号： A61K31/498 ,  C07D405/12 ,  C07D401/12 ,  C07D409/12 ,  C07D403/12 ,  A61P9/00

CPC分类号： C07D401/12 ,  C07D405/12 ,  C07D409/12

公开(公告)号：EP1709043B1

公开(公告)日：2008-12-03

申请号：EP04798090.9

申请日：2004-11-26

申请人： Bayer HealthCare AG

发明人： BENNABI, Samir ,  HECKROTH, Heike ,  SCHIROK, Hartmut ,  MITTENDORF, Joachim ,  KAST, Raimund ,  STASCH, Johannes-Peter ,  GNOTH, Mark Jean ,  MÜNTER, Klaus ,  LANG, Dieter ,  PEREZ, Santiago Figueroa ,  BAUSER, Marcus ,  FEURER, Achim ,  EHMKE, Heimo

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The invention relates to benzols containing heteroaryl substitutes of formula (1), a method for the production and the use thereof for producing drugs for treating and/or preventing human and animal diseases, en particular cardiovascular diseases.

公开(公告)号：EP1572628B1

公开(公告)日：2007-07-25

申请号：EP03782248.3

申请日：2003-11-28

申请人： Bayer HealthCare AG

发明人： HÄRTER, Michael ,  ERGÜDEN, Jens ,  WUNDER, Frank ,  TINEL, Hanna ,  KÖBBERLING, Johannes ,  BECKER, Eva-Maria ,  MÜNTER, Klaus ,  SCHLEMMER, Karl-Heinz ,  KAST, Raimund ,  KOLKHOF, Peter ,  KARIG, Gunter ,  BÄRFACKER, Lars ,  HÜBSCH, Walter ,  SCHUHMACHER, Joachim ,  ZULEGER, Susanne ,  CONCEPCION, Arnel ,  SHIMIZU, Haruka

IPC分类号： C07C235/62 ,  C07D211/34 ,  C07D211/62 ,  C07D319/06 ,  C07D205/04 ,  C07D307/42 ,  C07D317/54 ,  C07D319/08 ,  C07D211/60 ,  A61K31/16 ,  A61K31/445 ,  A61P9/00

CPC分类号： C07D319/08 ,  C07C235/60 ,  C07C235/62 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D205/04 ,  C07D211/34 ,  C07D211/60 ,  C07D211/62 ,  C07D307/58 ,  C07D317/54 ,  C07D317/62 ,  C07D319/06 ,  C07D405/12

摘要： The invention relates to isophtalic acid derivatives, a method for the preparation thereof and the use of said derivatives for producing drugs for treating and/or preventing diseases, in particular cardiovascular diseases of a human being and animals.

公开(公告)号：EP1709043A1

公开(公告)日：2006-10-11

申请号：EP04798090.9

申请日：2004-11-26

申请人： Bayer HealthCare AG

发明人： BENNABI, Samir ,  HECKROTH, Heike ,  SCHIROK, Hartmut ,  MITTENDORF, Joachim ,  KAST, Raimund ,  STASCH, Johannes-Peter ,  GNOTH, Mark Jean ,  MÜNTER, Klaus ,  LANG, Dieter ,  PEREZ, Santiago Figueroa ,  BAUSER, Marcus ,  FEURER, Achim ,  EHMKE, Heimo

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The invention relates to benzols containing heteroaryl substitutes of formula (1), a method for the production and the use thereof for producing drugs for treating and/or preventing human and animal diseases, en particular cardiovascular diseases.

公开(公告)号：EP1572628A1

公开(公告)日：2005-09-14

申请号：EP03782248.3

申请日：2003-11-28

申请人： Bayer HealthCare AG

发明人： HÄRTER, Michael ,  ERGÜDEN, Jens ,  WUNDER, Frank ,  TINEL, Hanna ,  KÖBBERLING, Johannes ,  BECKER, Eva-Maria ,  MÜNTER, Klaus ,  SCHLEMMER, Karl-Heinz ,  KAST, Raimund ,  KOLKHOF, Peter ,  KARIG, Gunter ,  BÄRFACKER, Lars ,  HÜBSCH, Walter ,  SCHUHMACHER, Joachim ,  ZULEGER, Susanne ,  CONCEPCION, Arnel ,  SHIMIZU, Haruka

IPC分类号： C07C235/62 ,  C07D211/34 ,  C07D211/62 ,  C07D319/06 ,  C07D205/04 ,  C07D307/42 ,  C07D317/54 ,  C07D319/08 ,  C07D211/60 ,  A61K31/16 ,  A61K31/445 ,  A61P9/00

CPC分类号： C07D319/08 ,  C07C235/60 ,  C07C235/62 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D205/04 ,  C07D211/34 ,  C07D211/60 ,  C07D211/62 ,  C07D307/58 ,  C07D317/54 ,  C07D317/62 ,  C07D319/06 ,  C07D405/12

摘要： The invention relates to isophtalic acid derivatives, a method for the preparation thereof and the use of said derivatives for producing drugs for treating and/or preventing diseases, in particular cardiovascular diseases of a human being and animals.

摘要翻译： 本发明涉及间苯二甲酸衍生物，其制备方法及其用于制备用于治疗和/或预防人和动物特别是心血管疾病疾病的药物。