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公开(公告)号：EP1105371B1
公开(公告)日：2004-11-03
申请号：EP99940158.1
申请日：1999-08-06
申请人： Bayer HealthCare AG
发明人： MITTENDORF, Joachim , DRESSEL, Jürgen , MATZKE, Michael , KELDENICH, Jörg , MAULER, Frank , DE VRY, Jean-Marie, Victor , FRANZ, Jürgen , SPREYER, Peter , VÖHRINGER, Verena , SCHUMACHER, Joachim , ROCK, Michael-Harold , HORVATH, Ervin , FRIEDL, Arno
IPC分类号： C07C309/65 , A61K31/255
CPC分类号： C07C309/65 , C07C2602/08 , Y02P20/55
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2.发明授权PYRROLOPYRIDIN-SUBSTITUTIERTE BENZOL-DERIVATE ZUR BEHANDLUNG KARDIOVASKULÄRER ERKRANKUNGEN 有权吡咯并吡啶基取代的苯衍生物用于治疗心血管疾病的治疗
公开(公告)号：EP1709043B1
公开(公告)日：2008-12-03
申请号：EP04798090.9
申请日：2004-11-26
申请人： Bayer HealthCare AG
发明人： BENNABI, Samir , HECKROTH, Heike , SCHIROK, Hartmut , MITTENDORF, Joachim , KAST, Raimund , STASCH, Johannes-Peter , GNOTH, Mark Jean , MÜNTER, Klaus , LANG, Dieter , PEREZ, Santiago Figueroa , BAUSER, Marcus , FEURER, Achim , EHMKE, Heimo
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to benzols containing heteroaryl substitutes of formula (1), a method for the production and the use thereof for producing drugs for treating and/or preventing human and animal diseases, en particular cardiovascular diseases.
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3.发明公开PYRROLOPYRIDIN-SUBSTITUTIERTE BENZOL-DERIVATE ZUR BEHANDLUNG KARDIOVASKULÄRER ERKRANKUNGEN 有权吡咯并吡啶基取代的苯衍生物用于治疗心血管疾病的治疗
公开(公告)号：EP1709043A1
公开(公告)日：2006-10-11
申请号：EP04798090.9
申请日：2004-11-26
申请人： Bayer HealthCare AG
发明人： BENNABI, Samir , HECKROTH, Heike , SCHIROK, Hartmut , MITTENDORF, Joachim , KAST, Raimund , STASCH, Johannes-Peter , GNOTH, Mark Jean , MÜNTER, Klaus , LANG, Dieter , PEREZ, Santiago Figueroa , BAUSER, Marcus , FEURER, Achim , EHMKE, Heimo
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to benzols containing heteroaryl substitutes of formula (1), a method for the production and the use thereof for producing drugs for treating and/or preventing human and animal diseases, en particular cardiovascular diseases.
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公开(公告)号：EP1105370B1
公开(公告)日：2004-04-21
申请号：EP99940157.3
申请日：1999-08-06
申请人： Bayer HealthCare AG
发明人： MITTENDORF, Joachim , DRESSEL, Jürgen , MATZKE, Michael , KELDENICH, Jörg , MAULER, Frank , DE VRY, Jean-Marie-Victor , FRANZ, Jürgen , SPREYER, Peter , VÖHRINGER, Verena , SCHUMACHER, Joachim , ROCK, Michael-Harold , HORVATH, Ervin , FRIEDL, Arno , MOHRS, Klaus-Helmut , RADDATZ, Siegfried , JORK, Reinhard
IPC分类号： C07C309/65 , C07D307/80 , A61K31/255 , A61K31/343
CPC分类号： C07D307/80 , C07C309/65 , C07C2602/08
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5.发明授权
公开(公告)号：EP1751153B1
公开(公告)日：2008-12-03
申请号：EP05740054.1
申请日：2005-03-30
申请人： Bayer HealthCare AG
发明人： SCHIROK, Hartmut , RADTKE, Martin , MITTENDORF, Joachim , KAST, Raimund , STASCH, Johannes-Peter , GNOTH, Mark, Jean , MÜNTER, Klaus , LANG, Dieter , FIGUEROA, PEREZ, Santiago , THUTEWOHL, Michael , BENNABI, Samir , EHMKE, Heimo
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00
CPC分类号： C07D471/04
摘要： The invention relates to hetaryloxy-substituted phenylamino pyrimidines, a method for the production thereof, and the use thereof for producing medicaments utilized for the treatment and/or prevention of diseases in humans and animals, particularly cardiovascular diseases.
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公开(公告)号：EP2024361A1
公开(公告)日：2009-02-18
申请号：EP07724741.9
申请日：2007-04-30
申请人： Bayer HealthCare AG
发明人： FÜRSTNER, Chantal , SCHIROK, Hartmut , GRIEBENOW, Nils , MITTENDORF, Joachim , STASCH, Johannes-Peter , WUNDER, Frank
IPC分类号： C07D403/04 , C07D405/14 , C07D409/14 , C07D471/04 , A61K31/416 , A61K31/4162 , A61P7/00 , A61P9/00
CPC分类号： C07D405/14 , C07D403/04 , C07D409/14 , C07D471/04
摘要： The invention relates to novel 3-tetrazolyl indazole derivatives and 3-tetrazolyl pyrazolo[3,4-b]-pyridine derivatives, methods for producing the same, the exclusive or combined use thereof for treating and/or preventing diseases, and the use thereof for producing medicaments utilized for the treatment and/or prevention of diseases, particularly cardiovascular diseases.
摘要翻译： 本发明涉及新的3-四唑基吲唑衍生物和3-四唑基吡唑并[3,4-b] - 吡啶衍生物，其制备方法，其专有或组合用于治疗和/或预防疾病的用途及其用途 用于生产用于治疗和/或预防疾病，特别是心血管疾病的药物。
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7.发明公开HETEROCYCLISCH SUBSTITUIERTE, ANELLIERTE PYRAZOL-DERIVATE UND IHRE VERWENDUNG 审中-公开杂环取代的，稠合的吡唑衍生物及其
公开(公告)号：EP2013205A1
公开(公告)日：2009-01-14
申请号：EP07724280.8
申请日：2007-04-17
申请人： Bayer HealthCare AG
发明人： SCHIROK, Hartmut , GRIEBENOW, Nils , FÜRSTNER, Chantal , MITTENDORF, Joachim , STASCH, Johannes-Peter , WUNDER, Frank , SCHLEMMER, Karl-Heinz , HEITMEIER, Stefan , STOLL, Friederike
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00
CPC分类号： C07D471/04
摘要： The current registration relates to a new heterocylically substituted, anellated pyrazole derivative, and a process for its manufacture, its use by itself or in a combination to treat and/or prevent diseases as well as its use in the manufacture of medical drugs for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular illnessesdiseases.
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公开(公告)号：EP1742945A1
公开(公告)日：2007-01-17
申请号：EP05739438.9
申请日：2005-04-14
申请人： Bayer HealthCare AG
发明人： SCHIROK, Hartmut , STASCH, Johannes-Peter , KAST, Raimund , MÜNTER, Klaus , GNOTH, Mark, Jean , FIGUEROA, PEREZ, Santiago , THUTEWOHL, Michael , BENNABI, Samir , LANG, Dieter , MITTENDORF, Joachim , RADTKE, Martin , EHMKE, Heimo
IPC分类号： C07D471/04 , A61K31/437 , A61P9/10
CPC分类号： C07D471/04
摘要： The invention relates to substituted phenylamino-pyrimidines, to a method for their production and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular for the treatment of cardiovascular diseases.
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9.发明授权HETEROARYLOXY-SUBSTITUIERTE PHENYLAMINOPYRIMIDINE ALS RHO-KINASEINHIBITOREN 有权杂 - 取代苯基氨基AS RHO激酶抑制剂
公开(公告)号：EP1562935B1
公开(公告)日：2006-09-06
申请号：EP03769398.3
申请日：2003-10-16
申请人： Bayer HealthCare AG
发明人： FEURER, Achim , BENNABI, Samir , HECKROTH, Heike , SCHIROK, Hartmut , MITTENDORF, Joachim , KAST, Raimund , STASCH, Johannes-Peter , GNOTH, Mark, Jean , MÜNTER, Klaus , LANG, Dieter , FIGUEROA PEREZ, Santiago , EHMKE, Heimo
IPC分类号： C07D401/14 , C07D413/14 , C07D413/12 , C07D471/04 , C07D405/14 , C07D403/14 , C07D519/00 , A61K31/506 , A61P9/00
CPC分类号： C07D401/14 , C07D403/12 , C07D471/04
摘要： The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-kinase.
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10.发明公开HETEROARYLOXY-SUBSTITUIERTE PHENYLAMINOPYRIMIDINE ALS RHO-KINASEINHIBITOREN 有权杂 - 取代苯基氨基AS RHO激酶抑制剂
公开(公告)号：EP1562935A1
公开(公告)日：2005-08-17
申请号：EP03769398.3
申请日：2003-10-16
申请人： Bayer HealthCare AG
发明人： FEURER, Achim , BENNABI, Samir , HECKROTH, Heike , SCHIROK, Hartmut , MITTENDORF, Joachim , KAST, Raimund , STASCH, Johannes-Peter , GNOTH, Mark, Jean , MÜNTER, Klaus , LANG, Dieter , FIGUEROA PEREZ, Santiago , EHMKE, Heimo
IPC分类号： C07D401/14 , C07D413/14 , C07D413/12 , C07D471/04 , C07D405/14 , C07D403/14 , C07D519/00 , A61K31/506 , A61P9/00
CPC分类号： C07D401/14 , C07D403/12 , C07D471/04
摘要： The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-kinase.
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