公开(公告)号：EP1797037A1

公开(公告)日：2007-06-20

申请号：EP05794785.5

申请日：2005-09-20

申请人： Bayer HealthCare AG

发明人： LÖGERS, Michael ,  GEHRING, Reinhold ,  KUHN, Oliver ,  MATTHÄUS, Mike ,  MOHRS, Klaus ,  MÜLLER-GLIEMANN, Matthias ,  STIEHL, Jürgen ,  BERWE, Mathias ,  LENZ, Jana ,  HEILMANN, Werner

IPC分类号： C07D213/81

CPC分类号： C07D213/81

摘要： The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide and its tosylate salt. Formula (I), which comprises, in a first step, reacting the compound of the formula (V) with 4-chloro-3-trifluoromethylphenyl isocyanate in a nonchlorinated organic solvent, inert toward isocyanates, by initially charging the compound of the formula (V) at a temperature of from 20°C to 60°C and admixing with 4-chloro-3-trifluoromethylphenyl isocyanate in such a way that the reaction temperature does not exceed 70°C to give the compound of the formula (II) and, in a second step, admixing the compound of the formula (II) with p-toluenesulfonic acid in a polar solvent at a reaction temperature of from 40°C up to the reflux temperature of the solvent used.

公开(公告)号：EP1034173B1

公开(公告)日：2005-04-27

申请号：EP98959874.3

申请日：1998-11-12

申请人： Bayer HealthCare AG

发明人： GEHRING, Reinhold ,  MOHRS, Klaus ,  HEILMANN, Werner ,  DIEHL, Herbert

IPC分类号： C07D401/00

CPC分类号： C07D471/04 ,  A01N43/90

摘要： The invention relates to a novel method for producing 8-methoxy-quinoline carboxylic acids which depict antibiotics having a high antibacterial action.