公开(公告)号：EP1797037A1

公开(公告)日：2007-06-20

申请号：EP05794785.5

申请日：2005-09-20

申请人： Bayer HealthCare AG

发明人： LÖGERS, Michael ,  GEHRING, Reinhold ,  KUHN, Oliver ,  MATTHÄUS, Mike ,  MOHRS, Klaus ,  MÜLLER-GLIEMANN, Matthias ,  STIEHL, Jürgen ,  BERWE, Mathias ,  LENZ, Jana ,  HEILMANN, Werner

IPC分类号： C07D213/81

CPC分类号： C07D213/81

摘要： The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide and its tosylate salt. Formula (I), which comprises, in a first step, reacting the compound of the formula (V) with 4-chloro-3-trifluoromethylphenyl isocyanate in a nonchlorinated organic solvent, inert toward isocyanates, by initially charging the compound of the formula (V) at a temperature of from 20°C to 60°C and admixing with 4-chloro-3-trifluoromethylphenyl isocyanate in such a way that the reaction temperature does not exceed 70°C to give the compound of the formula (II) and, in a second step, admixing the compound of the formula (II) with p-toluenesulfonic acid in a polar solvent at a reaction temperature of from 40°C up to the reflux temperature of the solvent used.

公开(公告)号：EP1345939B1

公开(公告)日：2006-06-07

申请号：EP01271374.9

申请日：2001-12-05

申请人： Bayer HealthCare AG

发明人： NOWAKOWSKI, Marc ,  GEHRING, Reinhold ,  HEILMANN, Werner ,  WAHL, Karl-Heinz

IPC分类号： C07D487/04 ,  C07D253/00 ,  C07D235/00

CPC分类号： C07D487/04

摘要： The invention relates to a method for producing sulfonamide-substituted imidazotriazinones of the general formula (I). The inventive method is characterized by reacting the compounds of formula (II) with sulfuric acid and then reacting the products obtained with thionylchloride and in situ in an inert solvent with an amine to give the compounds according to the invention or optionally the corresponding salts, hydrates or N-oxides.

公开(公告)号：EP1034173B1

公开(公告)日：2005-04-27

申请号：EP98959874.3

申请日：1998-11-12

申请人： Bayer HealthCare AG

发明人： GEHRING, Reinhold ,  MOHRS, Klaus ,  HEILMANN, Werner ,  DIEHL, Herbert

IPC分类号： C07D401/00

CPC分类号： C07D471/04 ,  A01N43/90

摘要： The invention relates to a novel method for producing 8-methoxy-quinoline carboxylic acids which depict antibiotics having a high antibacterial action.