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1.发明授权4-HETEROARYL-TETRAHYDROCHINOLINE UND IHRE VERWENDUNG ALS INHIBITOREN DES CHOLESTERIN-ESTER-TRANSFER-PROTEINS (CTEP) 有权4-杂芳基 - 四氢喹啉及其作为胆固醇酯转移蛋白抑制剂（CTEP）
公开(公告)号：EP1017692B1
公开(公告)日：2004-03-03
申请号：EP98948919.0
申请日：1998-09-07
申请人： Bayer HealthCare AG
发明人： STOLTEFUSS, Jürgen , LÖGERS, Michael , SCHMIDT, Gunter , BRANDES, Arndt , SCHMECK, Carsten , BREMM, Klaus-Dieter , BISCHOFF, Hilmar , SCHMIDT, Delf
IPC分类号： C07D409/04 , A61K31/47 , C07D401/04 , C07D405/04 , C07D215/20 , C07F7/18
CPC分类号： C07D401/04 , C07D215/20 , C07D409/04
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2.发明公开PROCESS FOR THE PREPARATION OF 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENYOXY}N-METHYLPYRIDINE-2-CARBOXAMIDE 有权PROCESS FOR的制备4- {4 - [（{[4-氯-3-（三氟甲基）苯基]氨基}羰基）氨基] PHENYOXY} -N-甲基吡啶-2-甲酰胺
公开(公告)号：EP1797037A1
公开(公告)日：2007-06-20
申请号：EP05794785.5
申请日：2005-09-20
申请人： Bayer HealthCare AG
发明人： LÖGERS, Michael , GEHRING, Reinhold , KUHN, Oliver , MATTHÄUS, Mike , MOHRS, Klaus , MÜLLER-GLIEMANN, Matthias , STIEHL, Jürgen , BERWE, Mathias , LENZ, Jana , HEILMANN, Werner
IPC分类号： C07D213/81
CPC分类号： C07D213/81
摘要： The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide and its tosylate salt. Formula (I), which comprises, in a first step, reacting the compound of the formula (V) with 4-chloro-3-trifluoromethylphenyl isocyanate in a nonchlorinated organic solvent, inert toward isocyanates, by initially charging the compound of the formula (V) at a temperature of from 20°C to 60°C and admixing with 4-chloro-3-trifluoromethylphenyl isocyanate in such a way that the reaction temperature does not exceed 70°C to give the compound of the formula (II) and, in a second step, admixing the compound of the formula (II) with p-toluenesulfonic acid in a polar solvent at a reaction temperature of from 40°C up to the reflux temperature of the solvent used.
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公开(公告)号：EP1017659B1
公开(公告)日：2005-04-27
申请号：EP98951408.8
申请日：1998-09-16
申请人： Bayer HealthCare AG
发明人： BRANDES, Arndt , LÖGERS, Michael , STOLTEFUSS, Jürgen , SCHMIDT, Gunter , BREMM, Klaus-Dieter , BISCHOFF, Hilmar , SCHMIDT, Delf , ANTONS, Stefan , PAULSEN, Holger , MÜLLER, Stephan, Nicholas , NAAB, Paul , SCHMECK, Carsten
IPC分类号： C07C35/52 , C07C43/192 , C07C49/813 , C07C49/83 , C07F7/18
CPC分类号： C07C69/76 , C07C35/52 , C07C43/192 , C07C49/83 , C07C69/757 , C07C69/94 , C07F7/1856
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