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公开(公告)号:EP1465623A1
公开(公告)日:2004-10-13
申请号:EP02805752.9
申请日:2002-12-13
申请人: Bayer HealthCare AG
发明人: YURA, Takeshi , MOGI, Muneto , IKEGAMI, Yuka , MASUDA, Tsutomu , KOKUBO, Toshio , URBAHNS, Klaus , Y0SHIDA, Nagahiro , MARUMO, Makiko , SHIROO, Masahiro , TAJIMI, Masaomi , Takeshita, Keisuke,435-1-202 , MORIWAKI, Toshiya , TSUKIMI, Yasuhiro
IPC分类号: A61K31/428 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/365 , A61K31/404 , C07D277/72 , C07D277/62 , C07D277/74 , C07D277/64 , C07D209/08 , C07D231/56 , C07D249/18 , C07D235/06 , C07D333/54
CPC分类号: C07D333/54 , A61K31/365 , A61K31/404 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/428 , C07D209/08 , C07D231/56 , C07D235/06 , C07D235/08 , C07D235/10 , C07D249/18 , C07D277/62 , C07D277/64 , C07D277/72 , C07D277/74 , C07D307/83
摘要: A medicament which contains a urea derivative or a salt thereof as an active ingredient is disclosed. The medicament has an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence and/or inflammatory disorders.
摘要翻译: 公开了含有脲衍生物或其盐作为活性成分的药物。 该药物作为VR1拮抗剂具有极好的活性,可用于预防和治疗与VR1活性相关的疾病,特别是用于治疗急迫性尿失禁,膀胱活动过度,慢性疼痛,神经性疼痛,术后疼痛,类风湿性关节炎疼痛,神经痛 ,神经病,痛觉过敏,神经损伤,局部缺血,神经变性,中风,失禁和/或炎性病症。