公开(公告)号：EP3105209B1

公开(公告)日：2019-08-21

申请号：EP15703288.9

申请日：2015-02-10

申请人： Bayer Pharma Aktiengesellschaft

发明人： REHWINKEL, Hartmut ,  PANKNIN, Olaf ,  RING, Sven ,  ANLAUF, Sonja ,  SIEBENEICHER, Holger ,  NGUYEN, Duy ,  SCHWEDE, Wolfgang ,  BAUSER, Marcus ,  ZIMMERMANN, Katja ,  KAULFUSS, Stefan ,  NEUHAUS, Roland ,  BLANEY, Paul, Matthew

IPC分类号： C07D235/30 ,  A61K31/4184 ,  A61P35/00

公开(公告)号：EP3105209A1

公开(公告)日：2016-12-21

申请号：EP15703288.9

申请日：2015-02-10

申请人： Bayer Pharma Aktiengesellschaft

发明人： REHWINKEL, Hartmut ,  PANKNIN, Olaf ,  RING, Sven ,  ANLAUF, Sonja ,  SIEBENEICHER, Holger ,  NGUYEN, Duy ,  SCHWEDE, Wolfgang ,  BAUSER, Marcus ,  ZIMMERMANN, Katja ,  KAULFUSS, Stefan ,  NEUHAUS, Roland ,  BLANEY, Paul, Matthew

IPC分类号： C07D235/30 ,  A61K31/4184 ,  A61P35/00

CPC分类号： C07D235/30 ,  A61K31/4184 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/12

摘要： The present invention relates to benzimidazol-2-amines of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.