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公开(公告)号：EP3395818A1
公开(公告)日：2018-10-31
申请号：EP18167649.5
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje-Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib),
to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.-
公开(公告)号：EP3177619B1
公开(公告)日：2018-04-25
申请号：EP15744596.6
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP3177619A1
公开(公告)日：2017-06-14
申请号：EP15744596.6
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
摘要翻译： 制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合以及用于制备用于治疗或预防疾病，特别是过度增殖的药物组合物的所述化合物的用途 疾病作为唯一的药剂或与其他活性成分组合。
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公开(公告)号：EP3700904A1
公开(公告)日：2020-09-02
申请号：EP18795421.9
申请日：2018-10-23
申请人： Bayer AG , BAYER PHARMA AKTIENGESELLSCHAFT , The Broad Institute, Inc. , Dana-Farber Cancer Institute Inc. et Al.
发明人： SIEGEL, Stephan , SIEGEL, Franziska , SCHULZE, Volker , BERGER, Markus , GRAHAM, Keith , KLAR, Ulrich , KNUT, Eis , SÜLZLE, Detlev , BÖMER, Ulf , KORR, Daniel , PETERSEN, Kirstin , MÖNNING, Ursula , EBERSPÄCHER, Uwe , MOOSMAYER, Dieter , MEYERSON, Matthew , GREULICH, Heidi , KAPLAN, Bethany , HARB, Hassan, Youssef , DINH, Phi, Manh
IPC分类号： C07D471/04 , A61P35/00 , A61K31/444 , A61K31/5377 , A61K31/4545
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