公开(公告)号：EP3313522A1

公开(公告)日：2018-05-02

申请号：EP16733024.0

申请日：2016-06-20

申请人： Bayer Pharma Aktiengesellschaft

发明人： LERCHEN, Hans-Georg ,  REBSTOCK, Anne-Sophie ,  CANCHO GRANDE, Yolanda ,  WITTROCK, Sven ,  BERNDT, Sandra ,  GRITZAN, Uwe ,  FITTING, Jenny ,  STELTE-LUDWIG, Beatrix ,  JONES, Patrick ,  MAHLERT, Christoph ,  VOTSMEIER, Christian ,  SCHÖNFELD, Dorian ,  TRAUTWEIN, Mark ,  WEBER, Ernst ,  PAWLOWSKI, Nikolaus ,  GREVEN, Simone ,  GLÜCK, Julian Marius ,  HAMMER, Stefanie ,  DIETZ, Lisa ,  MÄRSCH, Stephan

IPC分类号： A61P35/00

CPC分类号： A61K47/6865 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6863

摘要： The invention relates to novel antibody drug conjugates (ADCs), active metabolites of said ADCs, to methods for producing said ADCs, to the use of said ADCs for the treatment and/or prevention of diseases, and to the use of said ADCs for the production of medicaments for the treatment and/or prevention of diseases, in particular hyperproliferative and angiogenic diseases, such as cancer diseases. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.