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公开(公告)号：EP2694510A1
公开(公告)日：2014-02-12
申请号：EP12713963.2
申请日：2012-04-05
发明人： BÄRFACKER, Lars , SCOTT, William Johnston , HÄGEBARTH, Andrea , INCE, Stuart , REHWINKEL, Hartmut , POLITZ, Oliver , NEUHAUS, Roland , BRIEM, Hans , BÖMER, Ulf
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
摘要： Imidazopyridazines of formula (I) a process for their production and the use thereof.
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2.发明公开
公开(公告)号：EP2473498A1
公开(公告)日：2012-07-11
申请号：EP10747595.6
申请日：2010-08-24
发明人： BADER, Benjamin , BÖMER, Ulf , INCE, Stuart , KOPPITZ, Marcus , LIENAU, Philip , MARQUARDT, Tobias , NGUYEN, Duy , PRECHTL, Stefan , SIEMEISTER, Gerhard , WEGSCHEID-GERLACH, Christof
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D487/04 , A61K31/498 , A61K31/5377 , A61K31/551 , A61K31/513 , A61K31/506 , A61K31/4985
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted aminoquinoxaline compounds of general formula (I) in which (II), R
2 , R
3 , R
4 , R
6 , R
7 , n and m are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.摘要翻译： 本发明涉及通式（I）的取代氨基喹喔啉化合物，其中（II），R2，R3，R4，R6，R7，n和m如说明书和权利要求书中所给出，涉及制备所述化合物的方法 涉及包含所述化合物的药物组合物和组合，用于制备用于治疗或预防疾病的药物组合物的所述化合物的用途，以及可用于制备所述化合物的中间体化合物。
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公开(公告)号：EP2802586B1
公开(公告)日：2016-05-25
申请号：EP13700139.2
申请日：2013-01-08
发明人： BÄRFACKER, Lars , SCOTT, William , HÄGEBARTH, Andrea , INCE, Stuart , REHWINKEL, Hartmut , POLITZ, Oliver , NEUHAUS, Roland , BÖMER, Ulf
IPC分类号： A61K45/06
CPC分类号： C07D487/04 , A61K31/4985 , A61K45/06 , A61K2300/00
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4.发明授权
公开(公告)号：EP1807416B1
公开(公告)日：2012-08-29
申请号：EP05806225.8
申请日：2005-10-28
发明人： BOHLMANN, Rolf , HABEREY, Martin , HESS-STUMPP, Holger , HUTH, Andreas , INCE, Stuart , KRÜGER, Martin , THIERAUCH, Karl-Heinz
IPC分类号： C07D401/14 , C07D401/12
CPC分类号： C07D401/12 , C07D401/14
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公开(公告)号：EP2396330A1
公开(公告)日：2011-12-21
申请号：EP10703014.0
申请日：2010-02-02
发明人： VENNEMANN, Matthias , MAIER, Thomas , HÖLDER, Swen , BENEKE, Gerrit , DEHMEL, Florian , ZÜLCH, Armin , STRUB, Andreas , BECKERS, Thomas , INCE, Stuart , REHWINKEL, Hartmut , LIU, Ningshu , BÖMER, Ulf , BÄR, Thomas
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： A61K31/519 , A61K31/495 , A61K31/505 , A61K45/06 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Compounds of formula (I), or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6, R7, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
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公开(公告)号：EP2694510B1
公开(公告)日：2015-10-14
申请号：EP12713963.2
申请日：2012-04-05
发明人： BÄRFACKER, Lars , SCOTT, William Johnston , HÄGEBARTH, Andrea , INCE, Stuart , REHWINKEL, Hartmut , POLITZ, Oliver , NEUHAUS, Roland , BRIEM, Hans , BÖMER, Ulf
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
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公开(公告)号：EP2802586A1
公开(公告)日：2014-11-19
申请号：EP13700139.2
申请日：2013-01-08
发明人： BÄRFACKER, Lars , SCOTT, William , HÄGEBARTH, Andrea , INCE, Stuart , REHWINKEL, Hartmut , POLITZ, Oliver , NEUHAUS, Roland , BÖMER, Ulf
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4985 , A61K45/06 , A61K2300/00
摘要： Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
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公开(公告)号：EP2396331A1
公开(公告)日：2011-12-21
申请号：EP10703022.3
申请日：2010-02-05
发明人： VENNEMANN, Matthias , BÄR, Thomas , MAIER, Thomas , HÖLDER, Swen , BENEKE, Gerrit , DEHMEL, Florian , ZÜLCH, Armin , STRUB, Andreas , BECKERS, Thomas , INCE, Stuart , REHWINKEL, Hartmut , LIU, Ningshu , BÖMER, Ulf
IPC分类号： C07D487/04 , A61P35/00 , A61K31/517
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04
摘要： The present invention relates to compounds of formula (I), a N-oxide or tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6, R7, R10, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
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