公开(公告)号：EP3066100A1

公开(公告)日：2016-09-14

申请号：EP14793523.3

申请日：2014-11-03

申请人： Bayer Pharma Aktiengesellschaft

发明人： HASSFELD, Jorma ,  KINZEL, Tom ,  KÖBBERLING, Johannes ,  CANCHO GRANDE, Yolanda ,  BEYER, Kristin ,  RÖHRIG, Susanne ,  KÖLLNBERGER, Maria ,  SPERZEL, Michael ,  BURKHARDT, Nils ,  SCHLEMMER, Karl-Heinz ,  STEGMANN, Christian ,  SCHUHMACHER, Joachim ,  WERNER, Matthias ,  ELLERMANN, Manuel

IPC分类号： C07D487/04 ,  C07D487/12 ,  A61K31/519 ,  A61P7/04

CPC分类号： A61K31/519 ,  A61K45/06 ,  C07D471/14 ,  C07D487/04 ,  C07D487/12

摘要： The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

摘要翻译： 本申请涉及新的取代（氮杂）吡啶并吡咯并嘧啶酮和吲唑并嘧啶酮，其制备方法，单独使用的化合物或用于治疗和/或预防疾病，特别是用于治疗和/或预防的方法中的组合 在具有或不具有潜在的遗传性或获得性出血性疾病的患者中的急性和复发性出血，其中所述出血与选自月经过多，产后出血，出血性休克，创伤，手术，移植，中风， 肝脏疾病，遗传性血管性水肿，鼻出血和滑膜炎以及关节炎后的软骨损伤。

公开(公告)号：EP2569312A1

公开(公告)日：2013-03-20

申请号：EP11716595.1

申请日：2011-05-03

申请人： Bayer Pharma Aktiengesellschaft

发明人： HÄRTER, Michael ,  BECK, Hartmut ,  GRESCHAT-SCHADE, Susanne ,  ELLINGHAUS, Peter ,  UNTERSCHEMMANN, Kerstin ,  SCHUHMACHER, Joachim

IPC分类号： C07D413/14 ,  A61K31/4245 ,  A61P35/00

CPC分类号： A61K31/454 ,  A61K31/4245 ,  A61K45/06 ,  C07D413/14

摘要： The application relates to novel substituted 1-[3-(heterocyclyl)benzyl]-1
H -pyrazole derivatives, methods for the production thereof, the use thereof for the treatment and/or prevention of diseases, and the use thereof for the production of medicaments used for the treatment and/or prevention of diseases, in particular hyperproliferative and angiogenic diseases as well as diseases caused by metabolic adaptation to hypoxic conditions. Such treatments can be administered as monotherapy or in combination with other medicaments or other therapeutic measures.

公开(公告)号：EP3215505B1

公开(公告)日：2019-07-24

申请号：EP15788013.9

申请日：2015-10-30

申请人： Bayer Pharma Aktiengesellschaft

发明人： ELLERMANN, Manuel ,  VALOT, Gaelle ,  CANCHO GRANDE, Yolanda ,  HAßFELD, Jorma ,  KINZEL, Tom ,  KÖBBERLING, Johannes ,  BEYER, Kristin ,  RÖHRIG, Susanne ,  SPERZEL, Michael ,  STAMPFUß, Jan ,  MEYER, Imke ,  KÖLLNBERGER, Maria ,  BURKHARDT, Nils ,  SCHLEMMER, Karl-Heinz ,  STEGMANN, Christian ,  SCHUHMACHER, Joachim ,  WERNER, Matthias ,  HEIERMANN, Jörg ,  HENGEVELD, Willem Jan

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P7/04

公开(公告)号：EP3066100B1

公开(公告)日：2019-04-17

申请号：EP14793523.3

申请日：2014-11-03

申请人： Bayer Pharma Aktiengesellschaft

发明人： HASSFELD, Jorma ,  KINZEL, Tom ,  KÖBBERLING, Johannes ,  CANCHO GRANDE, Yolanda ,  BEYER, Kristin ,  RÖHRIG, Susanne ,  KÖLLNBERGER, Maria ,  SPERZEL, Michael ,  BURKHARDT, Nils ,  SCHLEMMER, Karl-Heinz ,  STEGMANN, Christian ,  SCHUHMACHER, Joachim ,  WERNER, Matthias ,  ELLERMANN, Manuel

IPC分类号： C07D487/04 ,  C07D487/12 ,  A61K31/519 ,  A61P7/04

公开(公告)号：EP3215505A1

公开(公告)日：2017-09-13

申请号：EP15788013.9

申请日：2015-10-30

申请人： Bayer Pharma Aktiengesellschaft

发明人： ELLERMANN, Manuel ,  VALOT, Gaelle ,  CANCHO GRANDE, Yolanda ,  HAßFELD, Jorma ,  KINZEL, Tom ,  KÖBBERLING, Johannes ,  BEYER, Kristin ,  RÖHRIG, Susanne ,  SPERZEL, Michael ,  STAMPFUß, Jan ,  MEYER, Imke ,  KÖLLNBERGER, Maria ,  BURKHARDT, Nils ,  SCHLEMMER, Karl-Heinz ,  STEGMANN, Christian ,  SCHUHMACHER, Joachim ,  WERNER, Matthias ,  HEIERMANN, Jörg ,  HENGEVELD, Willem Jan

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P7/04

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07D211/06 ,  C07D231/00 ,  C07D247/02 ,  C07D271/06 ,  C07D271/10 ,  C07D403/14 ,  C07D471/04

摘要： The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

摘要翻译： 本申请涉及新的取代的哌啶基吡唑并嘧啶酮，其制备方法，所述化合物单独或组合用于治疗和/或预防疾病，特别是用于治疗和/或预防急性和复发性出血 在具有或不具有遗传性或获得性止血障碍的患者中，其中出血与选自由重度月经出血，产后出血，失血性休克，出血性膀胱炎，胃肠道出血，外伤，手术，移植组成的组的疾病或医学干预有关 ，中风，肝脏疾病，遗传性血管性水肿，流鼻血，以及关节积血后的滑膜炎和软骨损伤。