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公开(公告)号：EP3215505B1
公开(公告)日：2019-07-24
申请号：EP15788013.9
申请日：2015-10-30
发明人： ELLERMANN, Manuel , VALOT, Gaelle , CANCHO GRANDE, Yolanda , HAßFELD, Jorma , KINZEL, Tom , KÖBBERLING, Johannes , BEYER, Kristin , RÖHRIG, Susanne , SPERZEL, Michael , STAMPFUß, Jan , MEYER, Imke , KÖLLNBERGER, Maria , BURKHARDT, Nils , SCHLEMMER, Karl-Heinz , STEGMANN, Christian , SCHUHMACHER, Joachim , WERNER, Matthias , HEIERMANN, Jörg , HENGEVELD, Willem Jan
IPC分类号： C07D487/04 , A61K31/519 , A61P7/04
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公开(公告)号：EP3197891B1
公开(公告)日：2018-11-21
申请号：EP15766510.0
申请日：2015-09-22
发明人： ROEHRIG, Susanne , HILLISCH, Alexander , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , SCHÄFER, Martina , TELLER, Henrik , JIMÈNEZ NÙNEZ, Eloisa
IPC分类号： C07D471/04 , A61K31/55 , A61P7/02 , A61P27/02
CPC分类号： C07D471/04
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3.发明授权
公开(公告)号：EP3197880B1
公开(公告)日：2018-10-24
申请号：EP15777624.6
申请日：2015-09-22
发明人： ROEHRIG, Susanne , HILLISCH, Alexander , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , TELLER, Henrik
IPC分类号： C07D401/12 , C07D405/06 , C07D213/69 , A61P7/02 , A61P29/00 , A61P1/04 , A61P27/02 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K9/20
CPC分类号： C07D213/69 , A61K9/0048 , A61K9/0095 , A61K9/2018 , A61K9/2027 , A61K9/2059 , A61K31/00 , A61K47/36 , A61P1/04 , A61P7/02 , A61P27/02 , A61P29/00 , C07D401/12 , C07D405/06
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公开(公告)号：EP3197889B1
公开(公告)日：2018-08-01
申请号：EP15766508.4
申请日：2015-09-22
发明人： RÖHRIG, Susanne , JIMENEZ NUNEZ, Eloisa , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , TELLER, Henrik , HILLISCH, Alexander , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , STAMPFUß, Jan
IPC分类号： C07D413/14 , C07D409/12 , C07D409/14 , A61K31/4436 , A61P1/00 , A61P27/02 , A61P29/00
CPC分类号： C07D413/14 , A61P1/00 , A61P27/02 , A61P29/00 , C07D409/12 , C07D409/14
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公开(公告)号：EP3197880A1
公开(公告)日：2017-08-02
申请号：EP15777624.6
申请日：2015-09-22
发明人： ROEHRIG, Susanne , HILLISCH, Alexander , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , TELLER, Henrik
IPC分类号： C07D401/12 , C07D405/06 , C07D213/69 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61P7/02
CPC分类号： C07D213/69 , A61K9/0048 , A61K9/0095 , A61K9/2018 , A61K9/2027 , A61K9/2059 , A61K31/00 , A61K47/36 , A61P1/04 , A61P7/02 , A61P27/02 , A61P29/00 , C07D401/12 , C07D405/06
摘要： The invention relates to substituted oxopyridine derivatives and methods for the production thereof, as well as to the use thereof in the production of medicinal drugs for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases, as well as oedemas, and also ophthalmological diseases.
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公开(公告)号：EP3063150A1
公开(公告)日：2016-09-07
申请号：EP14789580.9
申请日：2014-10-28
发明人： RÖHRIG, Susanne , HILLISCH, Alexander , STRASSBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina, Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , TELLER, Henrik , JIMENEZ NUNEZ, Eloisa , SCHIROK, Hartmut , KLAR, Jürgen
IPC分类号： C07D487/04 , A61K31/4188 , A61P7/02
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： The invention relates to substituted oxopyridine derivatives and methods for the production thereof, as well as to the use thereof in the production of medicinal drugs for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases, as well as oedemas, and also ophthalmological diseases. The oxopyridine derivatives inhibit factor XIa and plasma kallicrein.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及odemas以及眼科疾病的药物的用途 。
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7.发明公开
公开(公告)号：EP3046911A1
公开(公告)日：2016-07-27
申请号：EP14771828.2
申请日：2014-09-12
发明人： STRAUB, Alexander , COLLIN, Marie-Pierre , KOCH, Michael , MEYER, Jutta , SCHLEMMER, Karl-Heinz , NISING, Carl Friedrich , BIBER, Nicole , ANLAUF, Sonja , GROMOV, Alexey , WITTWER, Matthias Beat
IPC分类号： C07D239/36 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D409/06 , C07D409/04 , C07D411/04 , C07D413/04 , A61K31/513 , A61P9/00
CPC分类号： C07D401/04 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K45/06 , C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D411/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D471/04
摘要： The invention relates to novel heterocyclic substituted 6-(trifluoromethyl)pyrimidine- 4(3H)-one derivatives, to a method for the production thereof, to the use thereof either alone or in combination for the treatment and/or prevention of diseases, and to the use thereof for producing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.
摘要翻译： 本申请涉及新的杂环取代的6-（三氟甲基）嘧啶-4（3H） - 酮衍生物，其制备方法单独使用或组合用于治疗和/或预防疾病及其用途 用于制备用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管，肾，炎症和纤维化疾病的药物。
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公开(公告)号：EP2142504B1
公开(公告)日：2011-10-26
申请号：EP08716565.0
申请日：2008-03-15
发明人： HAHN, Michael , BECKER, Eva-Maria , KNORR, Andreas , SCHNEIDER, Dirk , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , WUNDER, Frank , LANG, Dieter
IPC分类号： C07D211/76 , C07D239/10 , C07D263/22 , C07D265/32 , C07D207/267
CPC分类号： C07D207/267 , C07D211/76 , C07D239/10 , C07D263/22 , C07D265/32
摘要： The invention relates to novel lactam-substituted dicarboxylic acid derivatives, to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention also relates to the use of said substances in the production of drugs for the treatment and/or prophylaxis of diseases, especially in the treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：EP3066100B1
公开(公告)日：2019-04-17
申请号：EP14793523.3
申请日：2014-11-03
发明人： HASSFELD, Jorma , KINZEL, Tom , KÖBBERLING, Johannes , CANCHO GRANDE, Yolanda , BEYER, Kristin , RÖHRIG, Susanne , KÖLLNBERGER, Maria , SPERZEL, Michael , BURKHARDT, Nils , SCHLEMMER, Karl-Heinz , STEGMANN, Christian , SCHUHMACHER, Joachim , WERNER, Matthias , ELLERMANN, Manuel
IPC分类号： C07D487/04 , C07D487/12 , A61K31/519 , A61P7/04
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公开(公告)号：EP3197896B1
公开(公告)日：2019-01-30
申请号：EP15771891.7
申请日：2015-09-22
发明人： ROEHRIG, Susanne , HILLISCH, Alexander , STRASSBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , TELLER, Henrik , JIMÉNEZ NÚNEZ, Eloisa , SCHIROK, Hartmut , KLAR, Juergen , LOBELL, Mario
IPC分类号： C07D471/04 , A61K31/435 , A61K31/437 , A61P7/02
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