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1.发明公开4- (4-CYANO-2-THIOARYL) -DIHYDROPYRIMIDINONE UND IHRE VERWENDUNG 有权4-（4-氰基-2-硫代芳基）-DIHYDROPYRIMIDINONE及其用途
公开(公告)号：EP2234985A1
公开(公告)日：2010-10-06
申请号：EP08864824.1
申请日：2008-12-09
发明人： VON NUSSBAUM, Franz , KARTHAUS, Dagmar , ANLAUF, Sonja , DELBECK, Martina , LI, Volkhart Min-Jian , MEIBOM, Daniel , LUSTIG, Klemens , SCHAMBERGER, Jens
IPC分类号： C07D239/22 , A61K31/505 , A61P11/00
CPC分类号： C07D487/04 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D239/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present application relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of disorders, and to the use thereof for production of medicaments for treatment and/or prevention of disorders, especially for treatment and/or prevention of disorders of the lung and of the cardiovascular system.
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公开(公告)号：EP2234980A1
公开(公告)日：2010-10-06
申请号：EP08864116.2
申请日：2008-12-09
发明人： NELL, Peter , VAKALOPOULOS, Alexandros , SÜSSMEIER, Frank , ALBRECHT-KÜPPER, Barbara , ZIMMERMANN, Katja , KELDENICH, Jörg , MEIBOM, Daniel
IPC分类号： C07D215/54 , C07D221/04 , C07D471/04 , A61P3/10 , A61P9/10 , A61K31/519 , A61K31/473
CPC分类号： C07D471/04 , C07D215/54 , C07D221/04
摘要： The invention relates to novel substituted fused cyanopyridine derivatives of formula (I), wherein the ring Q represents a group of formula (a), (b), (c), (d), (e), (f), (g) or (h), * representing the point of attachment to the C2 atom, # representing the point of attachment to the C3 atom. The invention also relates to methods for producing the novel derivatives, to the use thereof in the treatment and/or prevention of diseases and to their use in the production of drugs for use in the treatment and/or prevention of diseases, preferably in the treatment and/or prevention of cardiovascular diseases.
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3.发明公开
公开(公告)号：EP2297104A1
公开(公告)日：2011-03-23
申请号：EP09753647.8
申请日：2009-05-22
发明人： HÜBSCH, Walter , MEIBOM, Daniel , VAKALOPOULOS, Alexandros , ALBRECHT-KÜPPER, Barbara , NELL, Peter , ZIMMERMANN, Katja , SÜSSMEIER, Frank , KELDENICH, Joerg
IPC分类号： C07D213/70 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/33 , A61P9/00
CPC分类号： A61K31/44 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D213/70 , C07D213/85 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for preparation thereof, to the use thereof for treatment and/or prevention of disorders and to the use thereof for producing medicaments for treatment and/or prevention of disorders, preferably for treatment and/or prevention of cardiovascular disorders.
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公开(公告)号：EP2185550A1
公开(公告)日：2010-05-19
申请号：EP08774012.2
申请日：2008-07-17
发明人： NELL, Peter , HÜBSCH, Walter , ALBRECHT-KÜPPER, Barbara , KELDENICH, Jörg , VAKALOPOULOS, Alexandros , SÜSSMEIER, Frank , ZIMMERMANN, Katja , LANG, Dieter , MEIBOM, Daniel
IPC分类号： C07D413/12 , C07D413/14 , C07D419/14 , A61K31/40 , A61P9/06
CPC分类号： A61K31/4439 , A61K31/695 , A61K45/06 , C07D413/12 , C07D413/14 , C07D419/14 , C07F7/10
摘要： The present application relates to novel substituted aryloxazole derivatives, a method for the production thereof, the use thereof for the treatment and/or prophylaxis of diseases and the use thereof for the production of drugs for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.
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5.发明公开CYCLOALKOXY-SUBSTITUIERTE 4-PHENYL-3,5-DICYANOPYRIDINE UND IHRE VERWENDUNG 审中-公开环烷氧基 - 取代的-4-苯基-3,5- dicyanopyridines及其用途
公开(公告)号：EP2242741A1
公开(公告)日：2010-10-27
申请号：EP09711052.2
申请日：2009-01-31
发明人： HÜBSCH, Walter , NELL, Peter , SÜSSMEIER, Frank , VAKALOPOULOS, Alexandros , MEIBOM, Daniel , ALBRECHT-KÜPPER, Barbara , ZIMMERMANN, Katja
IPC分类号： C07D213/73 , C07D401/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/4427 , A61P9/00
CPC分类号： C07D213/73 , C07D401/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention relates to novel cycloalkoxy-substituted 4-phenyl-3,5-dicyanopyridine derivatives [of formula (l)],methods for production and use thereof for the treatment and/or prevention of diseases and use thereof for the production of medicaments for the treatment and/or prevention of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic diseases.
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6.发明公开
公开(公告)号：EP2285809A1
公开(公告)日：2011-02-23
申请号：EP09741818.0
申请日：2009-04-24
发明人： VON NUSSBAUM, Franz , KARTHAUS, Dagmar , DELBECK, Martina , LI, Volkhart Min-Jian , MEIBOM, Daniel , LUSTIG, Klemens
IPC分类号： C07D487/04 , A61K31/519 , A61P11/00
CPC分类号： C07D487/04
摘要： The present invention relates to new 1,4-diaryl-pyrimido[4,5-d]pyridazine-2,5-dione derivatives, to processes for preparing them, to their use, alone or in combinations, for treating and/or preventing diseases, and to their use for preparing pharmaceuticals for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of diseases of the lungs and of the cardiovascular system.
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7.发明公开SUBSTITUIERTE PYRROLO[2, 3-B]- UND PYRAZOLO[3, 4-B]PYRIDINE ALS ADENOSIN REZEPTOR LIGANDEN 有权取代的吡咯并[2,3-B] - 和吡唑并[3,4-b]吡啶ALS腺苷受体配体
公开(公告)号：EP2235011A1
公开(公告)日：2010-10-06
申请号：EP08864918.1
申请日：2008-12-09
发明人： NELL, Peter , VAKALOPOULOS, Alexandros , SÜSSMEIER, Frank , ALBRECHT-KÜPPER, Barbara , ZIMMERMANN, Katja , KELDENICH, Jörg , MEIBOM, Daniel
IPC分类号： C07D471/04 , A61P9/04 , A61P9/10 , A61P3/10 , A61K31/437
CPC分类号： C07D471/04
摘要： The invention relates to novel substituted pyrrolopyridine, pyrazolopyridine and isoxazolopyridine derivatives, to methods for producing the same, to the use thereof in the treatment and/or prevention of diseases and to their use in the production of drugs for use in the treatment and/or prevention of diseases, preferably in the treatment and/or prevention of cardiovascular diseases.
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