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1.发明公开CYCLOALKOXY-SUBSTITUIERTE 4-PHENYL-3,5-DICYANOPYRIDINE UND IHRE VERWENDUNG 审中-公开环烷氧基 - 取代的-4-苯基-3,5- dicyanopyridines及其用途
公开(公告)号：EP2242741A1
公开(公告)日：2010-10-27
申请号：EP09711052.2
申请日：2009-01-31
发明人： HÜBSCH, Walter , NELL, Peter , SÜSSMEIER, Frank , VAKALOPOULOS, Alexandros , MEIBOM, Daniel , ALBRECHT-KÜPPER, Barbara , ZIMMERMANN, Katja
IPC分类号： C07D213/73 , C07D401/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/4427 , A61P9/00
CPC分类号： C07D213/73 , C07D401/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention relates to novel cycloalkoxy-substituted 4-phenyl-3,5-dicyanopyridine derivatives [of formula (l)],methods for production and use thereof for the treatment and/or prevention of diseases and use thereof for the production of medicaments for the treatment and/or prevention of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic diseases.
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公开(公告)号：EP2321296A1
公开(公告)日：2011-05-18
申请号：EP09777798.1
申请日：2009-08-11
发明人： BÄRFACKER, Lars , KAST, Raimund , GRIEBENOW, Nils , MEIER, Heinrich , KOLKHOF, Peter , ALBRECHT-KÜPPER, Barbara , NITSCHE, Adam , STASCH, Johannes-Peter , SCHNEIDER, Dirk , TEUSCH, Nicole , RUDOLPH, Joachim , WHELAN, James , BULLOCK, William , PLEASIC-WILLIAMS, Susan
IPC分类号： C07D401/04 , C07D403/04 , C07D417/04 , C07D471/04 , A61K31/4155 , A61P13/12 , A61P9/00
CPC分类号： C07D403/04 , C07D401/04 , C07D417/04 , C07D471/04
摘要： The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases.
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公开(公告)号：EP2234980A1
公开(公告)日：2010-10-06
申请号：EP08864116.2
申请日：2008-12-09
发明人： NELL, Peter , VAKALOPOULOS, Alexandros , SÜSSMEIER, Frank , ALBRECHT-KÜPPER, Barbara , ZIMMERMANN, Katja , KELDENICH, Jörg , MEIBOM, Daniel
IPC分类号： C07D215/54 , C07D221/04 , C07D471/04 , A61P3/10 , A61P9/10 , A61K31/519 , A61K31/473
CPC分类号： C07D471/04 , C07D215/54 , C07D221/04
摘要： The invention relates to novel substituted fused cyanopyridine derivatives of formula (I), wherein the ring Q represents a group of formula (a), (b), (c), (d), (e), (f), (g) or (h), * representing the point of attachment to the C2 atom, # representing the point of attachment to the C3 atom. The invention also relates to methods for producing the novel derivatives, to the use thereof in the treatment and/or prevention of diseases and to their use in the production of drugs for use in the treatment and/or prevention of diseases, preferably in the treatment and/or prevention of cardiovascular diseases.
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4.发明公开
公开(公告)号：EP2297104A1
公开(公告)日：2011-03-23
申请号：EP09753647.8
申请日：2009-05-22
发明人： HÜBSCH, Walter , MEIBOM, Daniel , VAKALOPOULOS, Alexandros , ALBRECHT-KÜPPER, Barbara , NELL, Peter , ZIMMERMANN, Katja , SÜSSMEIER, Frank , KELDENICH, Joerg
IPC分类号： C07D213/70 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/33 , A61P9/00
CPC分类号： A61K31/44 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D213/70 , C07D213/85 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for preparation thereof, to the use thereof for treatment and/or prevention of disorders and to the use thereof for producing medicaments for treatment and/or prevention of disorders, preferably for treatment and/or prevention of cardiovascular disorders.
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公开(公告)号：EP2185550A1
公开(公告)日：2010-05-19
申请号：EP08774012.2
申请日：2008-07-17
发明人： NELL, Peter , HÜBSCH, Walter , ALBRECHT-KÜPPER, Barbara , KELDENICH, Jörg , VAKALOPOULOS, Alexandros , SÜSSMEIER, Frank , ZIMMERMANN, Katja , LANG, Dieter , MEIBOM, Daniel
IPC分类号： C07D413/12 , C07D413/14 , C07D419/14 , A61K31/40 , A61P9/06
CPC分类号： A61K31/4439 , A61K31/695 , A61K45/06 , C07D413/12 , C07D413/14 , C07D419/14 , C07F7/10
摘要： The present application relates to novel substituted aryloxazole derivatives, a method for the production thereof, the use thereof for the treatment and/or prophylaxis of diseases and the use thereof for the production of drugs for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.
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6.发明公开SUBSTITUIERTE 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDE UND IHRE VERWENDUNG 有权取代的4-芳基-1,4-二氢-1,6- NAPHTHYRIDINAMIDE及其用途
公开(公告)号：EP2132206A2
公开(公告)日：2009-12-16
申请号：EP08715849.9
申请日：2008-02-19
发明人： BÄRFACKER, Lars , KOLKHOF, Peter , SCHLEMMER, Karl-Heinz , GROSSER, Rolf , NITSCHE, Adam , KLEIN, Martina , MÜNTER, Klaus , ALBRECHT-KÜPPER, Barbara , HARTMANN, Elke
IPC分类号： C07D471/04 , A61K31/437 , A61P9/10
CPC分类号： C07D471/04
摘要： The invention relates to novel 4-aryl-1,4-dihydro-1,6-naphthyridin-3- carboxamides, methods for production and use thereof for the treatment and/or prophylaxis of diseases and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular, cardiovascular diseases.
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公开(公告)号：EP2118135A1
公开(公告)日：2009-11-18
申请号：EP07818640.0
申请日：2007-10-02
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT-KÜPPER, Barbara , KLEIN, Martina
CPC分类号： G01N33/6887 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The invention provides CRTAC which is associated with the cardiovascular diseases, hematological diseases, respiratory diseases, cancer, gastrointestinal and liver disease, inflammation, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, respiratory diseases, cancer, gastrointestinal and liver disease, inflammation, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CRTAC as well as pharmaceutical compositions comprising such compounds. The invention also provides CRTAC as a biomarker for diseases as cardiovascular diseases, hematological diseases, respiratory diseases, cancer, gastrointestinal and liver disease, inflammation, neurological diseases and urological diseases.
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公开(公告)号：EP2102357A1
公开(公告)日：2009-09-23
申请号：EP07818638.4
申请日：2007-10-02
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT-KÜPPER, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , Y10S530/841
摘要： The invention provides LTBP2 which is associated with the cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of LTBP2 as well as pharmaceutical compositions comprising such compounds. The invention also provides LTBP2 as a biomarker for diseases as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases
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9.发明公开CYCLISCH SUBSTITUIERTE 3,5-DICYANO-2-THIOPYRIDINE UND IHRE VERWENDUNG 有权环取代的3,5-二氰基-2- thiopyridines及其用途
公开(公告)号：EP2099788A1
公开(公告)日：2009-09-16
申请号：EP07846651.3
申请日：2007-11-17
发明人： NELL, Peter , HÜBSCH, Walter , ALBRECHT-KÜPPER, Barbara , VAKALOPOULOS, Alexandros , SÜSSMEIER, Frank , KELDENICH, Jörg , TELSER, Joachim
IPC分类号： C07D405/04 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/4439 , A61P9/00
CPC分类号： C07D417/14 , C07D405/04 , C07D413/14 , C07D417/12
摘要： The invention relates to novel 4-cycloalkyl- and 4-heterocycloalkyl-3,5-dicyano-2-thiopyridine derivatives, to a method for their production, to the use thereof for the treatment and/or prophylaxis of diseases and to the use of said derivatives for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertonia and other cardiovascular diseases.
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公开(公告)号：EP2296641A1
公开(公告)日：2011-03-23
申请号：EP09768919.4
申请日：2009-06-16
IPC分类号： A61K31/166 , A61K31/17 , A61K31/435 , A61P9/00
CPC分类号： A61K31/44
摘要： The present invention relates to pharmaceutical compositions and combinations for treating, preventing or managing heart failure and/or connected diseases therewith comprising 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide optionally combined with at least one additional therapeutic agent.
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