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1.发明公开
公开(公告)号：EP3489260A1
公开(公告)日：2019-05-29
申请号：EP19150601.3
申请日：2008-02-22
摘要： The present invention includes compositions and methods for targeting the LOX-1 receptor on immune cells and uses for the anti-LOX-1 antibodies.
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公开(公告)号：EP3489260B1
公开(公告)日：2020-12-02
申请号：EP19150601.3
申请日：2008-02-22
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3.发明授权THERAPEUTIC APPLICATIONS OF ACTIVATION OF HUMAN ANTIGEN-PRESENTING CELLS THROUGH DECTIN-1 有权细胞与人抗原的BY的Dectin-1的活化治疗应用
公开(公告)号：EP2129773B1
公开(公告)日：2013-02-13
申请号：EP08799678.1
申请日：2008-02-22
IPC分类号： C12N5/07 , A61K39/395 , C07K16/28
CPC分类号： C07K16/2851 , A61K39/395 , A61K2039/5154 , A61K2039/5158 , C07K16/1018 , C07K2317/24 , C07K2317/74 , C07K2317/92 , C07K2319/00 , C12N5/0639 , C12N9/2402 , C12N2501/22 , C12N2501/23 , C12N2501/50 , C12N2501/998
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4.发明公开METHODS AND COMPOSITIONS FOR TREATING AUTOIMMUNE AND INFLAMMATORY CONDITIONS 审中-公开方法和组合物用于治疗自身免疫性疾病和炎症疾病的治疗
公开(公告)号：EP3142691A1
公开(公告)日：2017-03-22
申请号：EP15792154.5
申请日：2015-05-15
发明人： OH, SangKon , ZURAWSKI, Sandra , JOO, Hyemee , ZURAWSKI, Gerard
CPC分类号： A61K38/2066 , A61K39/0008 , A61K2039/505 , A61K2039/54 , A61K2039/57 , C07K14/5428 , C07K16/2851 , C07K16/2878 , C07K2317/24 , C07K2317/40 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2319/00
摘要： Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.
摘要翻译： 描述的组合物和用于抑制炎症或自身免疫应答的方法和用于在有需要的受试者中诱导免疫耐受，其包括施用给所述受试者治疗有效量的有效连接到IL-10的抗原呈递细胞（APC）靶向性抗体的 或其片段。 的组合物和所描述的方法可用于治疗炎症和自身免疫病症。
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5.发明公开DENDRITIC CELL ASGPR TARGETING IMMUNOTHERAPEUTICS FOR MULTIPLE SCLEROSIS 审中-公开GEGEN DENDRITISCHE ZELL-ASGPR GERICHTETE IMMUNTHERAPEUTIKAFÜRMULTIPLE SKLEROSE
公开(公告)号：EP3013362A1
公开(公告)日：2016-05-04
申请号：EP14817259.6
申请日：2014-06-27
发明人： OH, SangKon , ZURAWSKI, Gerard
IPC分类号： A61K39/00
CPC分类号： A61K39/0008 , A61K2039/505 , A61K2039/577 , C07K14/46 , C07K16/28 , C07K2319/33
摘要： Methods and compositions for treating multiple sclerosis using dendritic cell anti-ASGPR antibodies fused to myelin basic protein or myelin oligodendrocyte glycoprotein provided.
摘要翻译： 使用与髓磷脂碱性蛋白或髓鞘少突胶质细胞糖蛋白融合的树突细胞抗ASGPR抗体治疗多发性硬化症的方法和组合物。
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公开(公告)号：EP2635305A1
公开(公告)日：2013-09-11
申请号：EP11838568.1
申请日：2011-10-27
IPC分类号： A61K39/395 , A61K39/145 , A61P37/02 , A61K39/00 , A61P31/16
CPC分类号： C07K16/2851 , A61K39/12 , A61K39/145 , A61K39/385 , A61K39/39 , A61K47/36 , A61K47/42 , A61K2039/55572 , A61K2039/6056 , C07K2317/76 , C07K2319/035 , C12N2760/16134
摘要： Compositions and methods for enhancing Th1/Th17 cell responses and decreasing Th2 cell responses are disclosed herein. In various embodiments the present invention describes activation of human dendritic cells and enhancement of antigen-specific T cell responses in a Dectin-1-expressing human dendritic cells comprising an anti-Dectin-1-specific antibody or fragment thereof fused with one or more antigens. TLR2 ligands may also be included to enhance the activation and for enhancement of T-cell responses. Further, the invention also includes methods based on the compositions described herein for the treatment of pathogenic infections.
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7.发明公开THERAPEUTIC APPLICATIONS OF ACTIVATION OF HUMAN ANTIGEN-PRESENTING CELLS THROUGH DECTIN-1 有权细胞与人抗原的BY的Dectin-1的活化治疗应用
公开(公告)号：EP2129773A2
公开(公告)日：2009-12-09
申请号：EP08799678.1
申请日：2008-02-22
IPC分类号： C12N5/06
CPC分类号： C07K16/2851 , A61K39/395 , A61K2039/5154 , A61K2039/5158 , C07K16/1018 , C07K2317/24 , C07K2317/74 , C07K2317/92 , C07K2319/00 , C12N5/0639 , C12N9/2402 , C12N2501/22 , C12N2501/23 , C12N2501/50 , C12N2501/998
摘要： The present invention includes compositions and methods for binding Dectin-1 on immune cells with anti-Dectin-1 -specific antibodies or fragment thereof capable of activating the immune cells.
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