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公开(公告)号：EP4265638A1
公开(公告)日：2023-10-25
申请号：EP21905330.3
申请日：2021-10-29
发明人： HE, Ting , QI, Feifei , LU, Xin-An , DING, Yanping , LIANG, Mengmeng
IPC分类号： C07K16/28 , C07K19/00 , C12N15/13 , C12N15/62 , C12N15/867 , C12N5/10 , A61K39/00 , A61P35/02
摘要： Provided in the present invention is a single-chain antibody scFv that specifically binds to CD123, including an amino acid sequence selected from SEQ ID NOs: 56, 57, 58, 59, 60 and 61. Also provided is a chimeric antigen receptor targeting CD123, including an amino acid sequence selected from SEQ ID NOs: 65, 66, 67, 68, 69 and 70. Further provided are a nucleic acid molecule encoding the scFv or chimeric antigen receptor, a vector and cell containing the nucleic acid molecule, and the use of the antibody, chimeric antigen receptor, nucleic acid molecule, vector or cell in the preparation of a drug for treating tumor expressing CD123.
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公开(公告)号：EP4104850A1
公开(公告)日：2022-12-21
申请号：EP21752943.7
申请日：2021-02-09
发明人： QI, Feifei , HE, Ting , LU, Xinan , DING, Yanping , XIONG, Fuyin , LIANG, Mengmeng
摘要： The present invention relates to the optimization of a chimeric antigen receptor, in particular, the modification of an intracellular signaling domain.
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公开(公告)号：EP4104840A1
公开(公告)日：2022-12-21
申请号：EP21753522.8
申请日：2021-02-09
发明人： LU, Xinan , HE, Ting , QI, Feifei , DING, Yanping , XIONG, Fuyin , LIANG, Mengmeng
IPC分类号： A61K35/14 , A61P35/00 , C07K16/28 , C07K14/705
摘要： The present invention relates to the optimization of a chimeric antigen receptor, in particular, the modification of an intracellular co-stimulatory domain.
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