公开(公告)号：EP2802334A1

公开(公告)日：2014-11-19

申请号：EP13736256.2

申请日：2013-01-14

Applicant: Bell Biosystems, Inc.

Inventor： BELL, Caleb B., III ,  BAZAROV, Alexey

IPC: A61K35/74

CPC classification number: C12N5/166 ,  C12N1/00 ,  C12N5/00 ,  C12N5/16 ,  C12N9/88 ,  C12N15/02 ,  C12N15/03 ,  C12Q1/6897 ,  C12Y406/01001

Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single- celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.

Abstract translation: 本发明一般涉及包含人造内分泌素的真核宿主细胞和将人造内共生体引入真核宿主细胞的方法。 本发明提供了将维持在子细胞中的宿主细胞引入表型的人造内共生体。 本发明另外提供含有磁脑细菌的真核宿主细胞。

公开(公告)号：EP2802334B1

公开(公告)日：2018-03-07

申请号：EP13736256.2

申请日：2013-01-14

Applicant: Bell Biosystems, Inc.

Inventor： BELL, Caleb B., III ,  BAZAROV, Alexey

IPC: C12N5/071 ,  C12N5/074 ,  C12N5/095 ,  C12N5/26 ,  C12N5/28

CPC classification number: C12N5/166 ,  C12N1/00 ,  C12N5/00 ,  C12N5/16 ,  C12N9/88 ,  C12N15/02 ,  C12N15/03 ,  C12Q1/6897 ,  C12Y406/01001

Abstract: The present invention relates to eukaryotic mammalian host cells comprising an artificial endosymbiont belonging to the class ±-Proteobacteria, wherein the host cell is selected from the group consisting of human cancer cells, inducible pluripotent stem (IPS) cells, hematopoietic stem cells, neural stem cells, epidermal neural crest stem cells, mammary stem cells, intestinal stem cells, mesenchymal stem cells, olfactory adult stem cells, testicular cells, and human cells found in the circulatory system.