公开(公告)号：EP4186896A1

公开(公告)日：2023-05-31

申请号：EP21847300.7

申请日：2021-07-22

申请人： Betta Pharmaceuticals Co., Ltd

发明人： WU, Hao ,  WU, Wenmao ,  LI, Ling ,  ZHANG, Zhan ,  WANG, Feng ,  YUAN, Ding ,  WU, Yunfei ,  CHEN, Qiang ,  HAN, Han ,  GUO, Jing ,  LAN, Hong ,  DING, Lieming ,  WANG, Jiabing

IPC分类号： C07D401/14 ,  C07D491/10 ,  C07D413/14 ,  C07D513/10 ,  C07D471/20 ,  C07D487/04 ,  A61K31/497 ,  A61P35/02 ,  A61P35/00

摘要： A compound (as represented by formula I) serving as an Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2) inhibitor, as well as a pharmaceutical composition thereof, a preparation method therefor, and a use in treating an SHP2 mediation diseases. The compounds of formula I exerts an effect by means of participating in the regulation of multiple processes such as cell proliferation, apoptosis, migration, and angiogenesis.