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公开(公告)号：EP4186896A1
公开(公告)日：2023-05-31
申请号：EP21847300.7
申请日：2021-07-22
发明人： WU, Hao , WU, Wenmao , LI, Ling , ZHANG, Zhan , WANG, Feng , YUAN, Ding , WU, Yunfei , CHEN, Qiang , HAN, Han , GUO, Jing , LAN, Hong , DING, Lieming , WANG, Jiabing
IPC分类号： C07D401/14 , C07D491/10 , C07D413/14 , C07D513/10 , C07D471/20 , C07D487/04 , A61K31/497 , A61P35/02 , A61P35/00
摘要： A compound (as represented by formula I) serving as an Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2) inhibitor, as well as a pharmaceutical composition thereof, a preparation method therefor, and a use in treating an SHP2 mediation diseases. The compounds of formula I exerts an effect by means of participating in the regulation of multiple processes such as cell proliferation, apoptosis, migration, and angiogenesis.
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公开(公告)号：EP3805217A1
公开(公告)日：2021-04-14
申请号：EP19815477.5
申请日：2019-06-06
发明人： WU, Hao , GU, Wei , TANG, Xiaojing , WANG, Wei , ZHAN, Bo , FENG, Dongjie , KE, Yongxin , CHEN, Zhongyan , SHEN, Yifei , WU, Wenmao , ZHAO, Xintao , LAN, Hong , WANG, Jiabing , DING, Lieming
IPC分类号： C07D413/04 , C07D417/04 , A61P35/00 , A61K31/506 , A61K31/4439 , A61K31/496 , A61K31/5377
摘要： Disclosed are a compound (as shown in formula I) as an extracellular signal-regulated kinase (ERK) inhibitor, a pharmaceutical composition thereof, a preparation method therefor, and use thereof in treating ERK-mediated diseases. Said compound plays a role by regulating a plurality of processes such as cell proliferation, apoptosis, migration and angiogenesis.
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