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公开(公告)号：EP4166542A1
公开(公告)日：2023-04-19
申请号：EP21820923.7
申请日：2021-06-10
发明人： YANG, Rongwen , SUN, Yun , ZHANG, Jian , LIU, Xiangkai , WANG, Pingping , YI, Xuegang , MA, Teng , HUANG, Chuanlong , LAN, Hong , DING, Lieming , WANG, Jiabing
IPC分类号： C07D243/36 , A61K31/403 , A61P35/00
摘要： The present invention relates to compounds of formula (I). The present invention also provides compositions and formulations containing such compounds, and methods for using and preparing such compounds.
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公开(公告)号：EP4196480A1
公开(公告)日：2023-06-21
申请号：EP21857661.9
申请日：2021-08-17
发明人： XU, Xiaofeng , GAO, Jinheng , RONG, Hongfei , SONG, Xizhen , CHEN, Jie , LIU, Xiangyong , SHEN, Hongling , GUO, Jing , YAN, Dan , LAN, Hong , DING, Lieming , WANG, Jiabing
IPC分类号： C07D487/00 , C07D487/04 , C07D491/052 , A61K31/395 , A61P35/00
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公开(公告)号：EP3967695A1
公开(公告)日：2022-03-16
申请号：EP20796227.5
申请日：2020-04-20
发明人： WU, Hao , LU, Yuan , YU, Jun , ZHOU, Xiao , LI, Boyan , HE, Jiangqi , FU, Shuibiao , YANG, Rongwen , LI, Yabin , WANG, Chao , WANG, Jiabing , LAN, Hong , DING, Lieming
IPC分类号： C07D471/10 , A61K31/517 , A61P35/00
摘要： The present invention relates to a novel compound, which has cancer therapeutic activity. The present invention also relates to a preparation method for the compound and a pharmaceutical composition containing the compound. (I)
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公开(公告)号：EP4360634A1
公开(公告)日：2024-05-01
申请号：EP22827568.1
申请日：2022-06-21
发明人： GUO, Jing , YAN, Dan , WANG, Yu , XU, Tong , LI, Kao , XU, Wei , LAN, Hong , DING, Lieming , WANG, Jiabing
IPC分类号： A61K31/4985 , A61P35/00
CPC分类号： A61K31/4985 , A61P35/00
摘要： The present invention provides an application of a compound in the preparation of drug for treating myelofibrosis and the related symptoms/signs thereof, and a use of the compound. The compound is selected form one or more of a compound having a structure as shown in formula I, and a pharmaceutically-acceptable salt, prodrug, solvate and hydrate thereof.
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公开(公告)号：EP4428125A1
公开(公告)日：2024-09-11
申请号：EP22889390.5
申请日：2022-11-03
发明人： YANG, Rongwen , SUN, Yun , ZHANG, Jian , YI, Xuegang , MA, Teng , WANG, Yu , WANG, Pingping , DING, Lieming , LAN, Hong , WANG, Jiabing
IPC分类号： C07D243/36 , A61P35/00 , A61K31/403
CPC分类号： A61K31/403 , C07D243/36 , A61P35/00
摘要： The present invention relates to a compound as shown in formula (I). The present invention also provides a composition and preparation containing the compound, and a method for using and preparing the compound.
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公开(公告)号：EP4212524A1
公开(公告)日：2023-07-19
申请号：EP21865940.7
申请日：2021-09-06
发明人： WU, Hao , YANG, Xiaofeng , LIU, Qisheng , HAN, Han , LI, Jinhua , LI, Yang , JIANG, Feng , KUANG, Cuiwen , XIA, Hongfeng , ZHANG, Hongbo , LAN, Hong , WANG, Jiabing , DING, Lieming
IPC分类号： C07D403/04 , A61K31/513 , A61P35/00
摘要： The present invention relates to a novel compound, which has cancer therapeutic activity. The present invention also relates to a preparation method for the compound and a pharmaceutical composition comprising the compound.
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公开(公告)号：EP4186896A1
公开(公告)日：2023-05-31
申请号：EP21847300.7
申请日：2021-07-22
发明人： WU, Hao , WU, Wenmao , LI, Ling , ZHANG, Zhan , WANG, Feng , YUAN, Ding , WU, Yunfei , CHEN, Qiang , HAN, Han , GUO, Jing , LAN, Hong , DING, Lieming , WANG, Jiabing
IPC分类号： C07D401/14 , C07D491/10 , C07D413/14 , C07D513/10 , C07D471/20 , C07D487/04 , A61K31/497 , A61P35/02 , A61P35/00
摘要： A compound (as represented by formula I) serving as an Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2) inhibitor, as well as a pharmaceutical composition thereof, a preparation method therefor, and a use in treating an SHP2 mediation diseases. The compounds of formula I exerts an effect by means of participating in the regulation of multiple processes such as cell proliferation, apoptosis, migration, and angiogenesis.
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公开(公告)号：EP3805217A1
公开(公告)日：2021-04-14
申请号：EP19815477.5
申请日：2019-06-06
发明人： WU, Hao , GU, Wei , TANG, Xiaojing , WANG, Wei , ZHAN, Bo , FENG, Dongjie , KE, Yongxin , CHEN, Zhongyan , SHEN, Yifei , WU, Wenmao , ZHAO, Xintao , LAN, Hong , WANG, Jiabing , DING, Lieming
IPC分类号： C07D413/04 , C07D417/04 , A61P35/00 , A61K31/506 , A61K31/4439 , A61K31/496 , A61K31/5377
摘要： Disclosed are a compound (as shown in formula I) as an extracellular signal-regulated kinase (ERK) inhibitor, a pharmaceutical composition thereof, a preparation method therefor, and use thereof in treating ERK-mediated diseases. Said compound plays a role by regulating a plurality of processes such as cell proliferation, apoptosis, migration and angiogenesis.
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