公开(公告)号：EP1410005A1

公开(公告)日：2004-04-21

申请号：EP02744465.2

申请日：2002-06-19

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： NAGHIEH, Hamid, R. ,  KOTCHOU, Keith ,  BHATT, Neeraj ,  GINGRICH, Jeffrey

IPC: G01N27/26

CPC classification number: G01N27/44721 ,  G01N21/276

Abstract: The optical imaging of two-dimensional solute zone arrays in electrophoresis gels is corrected for nonuniformities in the optical system such as those arising from the light source or from light dispersion underneath the gel. The correction is achieved by the use of a reference plate that responds to a light source uniformly along its length and width by being either uniformly light absorptive or uniformly light transmissive, or by emitting light upon excitation. Thus, any nonuniformities or deviations in the image of the reference plate arise only from nonuniformities or deviations within the optical system. Analogous corrections are made in other two-dimensional assay images, such as microarrays and microtiter plates.

公开(公告)号：EP2825867B1

公开(公告)日：2020-01-01

申请号：EP13761630.6

申请日：2013-03-14

Applicant: Bio-Rad Laboratories, Inc.

Inventor： KOTCHOU, Keith ,  MCDONALD, Kevin ,  LEE, James

IPC: G01N21/76

公开(公告)号：EP2438554B1

公开(公告)日：2020-04-01

申请号：EP10783936.7

申请日：2010-06-01

Applicant: Bio-Rad Laboratories, Inc.

Inventor： KOTCHOU, Keith ,  SCHULTZ, Christof ,  MCDONALD, Kevin ,  BHATT, Neeraj

IPC: G06T7/00

公开(公告)号：EP2825867A1

公开(公告)日：2015-01-21

申请号：EP13761630.6

申请日：2013-03-14

Applicant: Bio-rad Laboratories, Inc.

Inventor： KOTCHOU, Keith ,  MCDONALD, Kevin ,  LEE, James

IPC: G01N21/76

Abstract: An image system for detecting chemiluminescence in a sample uses a highly binned, short exposure initial image to calculate the exposure time for a final image of the sample. After calculation of the exposure time, at least two final images are taken, with saturated pixels removed and replaced in a first image with corresponding unsaturated pixels from a second image. The corresponding pixels are adjusted to reflect the different intensity levels between the first and second images, and the first image becomes the final image reflecting the detected chemiluminescence.

公开(公告)号：EP2438554A1

公开(公告)日：2012-04-11

申请号：EP10783936.7

申请日：2010-06-01

Applicant: Bio-Rad Laboratories, Inc.

Inventor： KOTCHOU, Keith ,  SCHULTZ, Christof ,  MCDONALD, Kevin ,  BHATT, Neeraj

IPC: G06K9/00

CPC classification number: G06T7/80 ,  G06T2207/30024 ,  G06T2207/30208

Abstract: Methods, apparatuses, and systems for imaging biological/chemical samples are provided. A calibrated imaging system can allow a user to obtain an optimal focus setting (position) for any effective distance (e.g. a zoom setting). The optimal focus can be determined from a functional approximation that defines a relationship between effective distance and focus setting. A user can input a size, and an imaging system can determine the appropriate effective distance and focus. An imaging system can also determine a size based on any effective distance. A flat-field correction can also be determined for any effective distance or size.

Abstract translation: 提供了用于成像生物/化学样品的方法，装置和系统。 校准的成像系统可以允许用户获得任何有效距离（例如，变焦设置）的最佳焦点设置（位置）。 可以从定义有效距离和焦点设置之间的关系的函数近似来确定最佳焦点。 用户可以输入尺寸，并且成像系统可以确定适当的有效距离和焦点。 成像系统还可以基于任何有效距离来确定尺寸。 对于任何有效的距离或大小，也可以确定平场校正。