公开(公告)号：EP2095104B1

公开(公告)日：2019-03-20

申请号：EP07865871.3

申请日：2007-12-19

Applicant: Bio-Rad Laboratories, Inc.

Inventor： MEHTA, Suresh, N. ,  BHATT, Neeraj ,  MCDONALD, Kevin A.

IPC: G01N30/95 ,  G01N27/447

公开(公告)号：EP1410005A1

公开(公告)日：2004-04-21

申请号：EP02744465.2

申请日：2002-06-19

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： NAGHIEH, Hamid, R. ,  KOTCHOU, Keith ,  BHATT, Neeraj ,  GINGRICH, Jeffrey

IPC: G01N27/26

CPC classification number: G01N27/44721 ,  G01N21/276

Abstract: The optical imaging of two-dimensional solute zone arrays in electrophoresis gels is corrected for nonuniformities in the optical system such as those arising from the light source or from light dispersion underneath the gel. The correction is achieved by the use of a reference plate that responds to a light source uniformly along its length and width by being either uniformly light absorptive or uniformly light transmissive, or by emitting light upon excitation. Thus, any nonuniformities or deviations in the image of the reference plate arise only from nonuniformities or deviations within the optical system. Analogous corrections are made in other two-dimensional assay images, such as microarrays and microtiter plates.

公开(公告)号：EP2438554B1

公开(公告)日：2020-04-01

申请号：EP10783936.7

申请日：2010-06-01

Applicant: Bio-Rad Laboratories, Inc.

Inventor： KOTCHOU, Keith ,  SCHULTZ, Christof ,  MCDONALD, Kevin ,  BHATT, Neeraj

IPC: G06T7/00

公开(公告)号：EP2438554A1

公开(公告)日：2012-04-11

申请号：EP10783936.7

申请日：2010-06-01

Applicant: Bio-Rad Laboratories, Inc.

Inventor： KOTCHOU, Keith ,  SCHULTZ, Christof ,  MCDONALD, Kevin ,  BHATT, Neeraj

IPC: G06K9/00

CPC classification number: G06T7/80 ,  G06T2207/30024 ,  G06T2207/30208

Abstract: Methods, apparatuses, and systems for imaging biological/chemical samples are provided. A calibrated imaging system can allow a user to obtain an optimal focus setting (position) for any effective distance (e.g. a zoom setting). The optimal focus can be determined from a functional approximation that defines a relationship between effective distance and focus setting. A user can input a size, and an imaging system can determine the appropriate effective distance and focus. An imaging system can also determine a size based on any effective distance. A flat-field correction can also be determined for any effective distance or size.

Abstract translation: 提供了用于成像生物/化学样品的方法，装置和系统。 校准的成像系统可以允许用户获得任何有效距离（例如，变焦设置）的最佳焦点设置（位置）。 可以从定义有效距离和焦点设置之间的关系的函数近似来确定最佳焦点。 用户可以输入尺寸，并且成像系统可以确定适当的有效距离和焦点。 成像系统还可以基于任何有效距离来确定尺寸。 对于任何有效的距离或大小，也可以确定平场校正。

公开(公告)号：EP2986957A1

公开(公告)日：2016-02-24

申请号：EP15785338.3

申请日：2015-04-29

Applicant: Bio-rad Laboratories, Inc.

Inventor： THRUSH, Evan ,  SWIHART, Steve ,  BHATT, Neeraj

IPC: G01J3/30 ,  F21V9/00

CPC classification number: G01N21/6456 ,  G01N21/6486 ,  G01N2021/6439 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2201/0638 ,  G01N2201/12

Abstract: An imaging assembly and processing system that includes a sample platform having a target region which can hold a sample, where the sample can be marked with fluorescent or phosphorescent markers. The imaging assembly can have an excitation light module proximate to the sample platform that emits light to excite the markers, and a lens module positioned to receive emission light from excited markers in target region. At least one series filter assembly or interference filter can be arranged in front of, behind, or both in front of and behind the lens module. The assembly includes a light sensor and a processor and imaging module configured to process data captured by the light sensor. Images of the sample are generated based on the emission light from the sample that transmit through and are filtered by the lens assembly and series filter assembly or interference filter.

Abstract translation: 一种成像组件和处理系统，其包括具有可容纳样品的目标区域的样品平台，其中可以用荧光或磷光标记物标记样品。 成像组件可以具有靠近样本平台的激发光模块，其发射光以激发标记;以及透镜模块，定位成接收来自目标区域中的激发标记的发射光。 至少一个串联滤波器组件或干涉滤波器可以布置在镜头模块前面，后面或者两者之间。 组件包括光传感器，以及配置成处理由光传感器捕获的数据的处理器和成像模块。 样品的图像基于来自透射的样品的发射光产生，并由透镜组件和串联滤光器组件或干涉滤光器滤波。

公开(公告)号：EP2382843A1

公开(公告)日：2011-11-02

申请号：EP10736323.6

申请日：2010-01-27

Applicant: Bio-Rad Laboratories, Inc.

Inventor： WALDBESER, David, E. ,  BHATT, Neeraj ,  MCDONALD, Kevin, A.

IPC: H05B35/00

CPC classification number: G01N27/44721 ,  G01N27/44726 ,  G01N27/44782

Abstract: An adaptor is designed as an accessory to an ultraviolet transilluminator for the excitation of fluorescent molecules or labels in a planar array of biochemical samples such as a two-dimensional electrophoresis gel to enable the emissions resulting from the excitation to be detected and quantified. The adaptor is constructed to overlay the transilluminator and contains both a fluorescent dye that upon excitation by ultraviolet light emits light in the visible spectrum, and a conditioning substance that selects a portion of the wavelength band of the visible light produced by the fluorescent dye. The adaptor converts the ultraviolet light from the transilluminator to visible light while limiting the emissions reaching the detector to those that emanate from the sample. By the use of this adaptor, the transilluminator is adapted for use with samples labeled with dyes that are excitable by visible light and avoids exposure of the samples and the user to ultraviolet light.

公开(公告)号：EP2095104A1

公开(公告)日：2009-09-02

申请号：EP07865871.3

申请日：2007-12-19

Applicant: Bio-Rad Laboratories, Inc.

Inventor： MEHTA, Suresh N. ,  BHATT, Neeraj ,  MCDONALD, Kevin A.

IPC: G01N30/00

CPC classification number: G01N27/44726 ,  G01N21/5911 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G01N30/95 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/062

Abstract: Images of two-dimensional chromatograms or other sample arrays are formed on a scanning instrument that utilizes a line of illumination light that sweeps the length of the array either by moving across the array or by the array moving relative to the light, in either case scanning the entire two-dimensional array with a unidirectional pass of the moving component. The use of a CCD equipped with time delay integration allows the instrument to form an enhanced image.